Cardiovascular effects of sympathomimetic amines injected into the cerebral ventricles of rabbits

Toda, Noboru; Matsuda, Yoshihisa; Shimamoto, Kiro

doi:10.1016/0028-3908(69)90061-6

Cited by 36 publications

(16 citation statements)

References 13 publications

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“…of mean). Toda et al 1969;Share & Melville, 1963;Nashold, Mannarino & Wunderlich,1962;Smookler et al 1966;McCubbin et al 1960;. Since the A xchycardia in the sheep was associated with a tendency for systolic B.P.…”

Section: Discussionmentioning

confidence: 99%

“…injections of these putative transmitters. In anaesthetized rats, rabbits, cats and dogs injection of noradrenaline into the lateral cerebral ventricle causes changes in cardiovascular function (Baum & Shropshire, 1973;Toda, Matsuda & Shimamoto, 1969; Smookler, Severs, Kinnard & Buckley, 1966; McCubbin, Bhargava, Mishra & Tangri, 1972). Little is known, however, about the cardiovascular responses of conscious animals to the i.c.y injection of noradrenaline, 5-hydroxytryptamine or carbachol, and whether or not any alterations in cardiovascular function caused by such i.c.v.…”

Section: Introductionmentioning

confidence: 99%

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Effect of intraventricular injection of transmitter substances and temperature on autonomic functions of conscious sheep.

Beal¹,

Bligh²

1979

The Journal of Physiology

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SUMMARY1. Changes in cardiovascular and renal functions following injection of noradrenaline, 5-hydroxytryptamine and carbachol into one lateral cerebral ventricle were investigated in conscious sheep at ambient air temperatures of 0 and 40 'C. The dose rates used were known to produce predictable changes in thermoregulation in sheep.2. The changes in body temperature, respiratory frequency and shivering caused by the intracerebroventricular (i.c.v.) injections of noradrenaline, 5-hydroxytryptamine and carbachol were as reported previously.3. The cardiovascular and renal responses of the sheep at both high and low ambient temperatures were consistent for each transmitter indicating that these activities had no major dependence on the type of thermoregulatory response.4. i.c.v. injection of noradrenaline increased heart rate and decreased pulse pressure but caused no change in mean arterial blood pressure (B.P.). Urine flow rate, sodium clearance, potassium clearance and osmolal clearance were decreased whereas solute-free water reabsorption was unaltered.5. ic.v. injection of 5-hydroxytryptamine caused no significant alterations in either cardiovascular or renal function.6. i.c.v. injection of carbachol increased systolic and diastolic B.P., heart rate and haematocrit. Sodium, potassium and osmolal clearances were increased after administration of carbachol.7. The changes in renal function after noradrenaline and carbachol injection could be explained by the concurrent changes in cardiovascular function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of intraventricular injection of transmitter substances and temperature on autonomic functions of conscious sheep.

Beal¹,

Bligh²

1979

The Journal of Physiology

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“…There is considerable evidence that central noradrenergic neurones influence heart rate not only by changes in peripheral sympathetic tone, but also by modifying vagal efferent activity. Intraventricular and intracisternal administration of noradrenaline results in cardiac slowing (McCubbin, Kaneko & Page, 1960;Toda, Matsuda & Shimamoto, 1969) which is greatly reduced by vagotomy (Share & Melville, 1963). However, intracisternal 6-OHD in rabbits causes a bradycardia which is completely abolished by atropine and which may persist for up to two weeks (Chalmers & Reid, 1972).…”

Section: Discussionmentioning

confidence: 99%

Central noradrenergic neurones and the cardiovascular actions of clonidine in the rabbit

Dollery¹,

Reid²

1973

British J Pharmacology

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Summary1. Clonidine (1 ,ug/kg), given by intracisternal injection to anaesthetized rabbits, lowered mean arterial blood pressure by 33 mmHg and heart rate by 32 beats/min.2. In animals pre-treated with 6-hydroxydopamine (6-OHD 500 ,ug/kg intracisternally) 7-10 days before, intracisternal clonidine (1 ,ug/kg) reduced mean arterial blood pressure by only 2-5 mmHg and heart rate by 4 beats/minute.3. The hypotensive action of intravenous clonidine was reduced to 49% of control by pre-treatment with intracisternal 6-OHD. In unanaesthetized normal animals intravenous clonidine (30 ,ug/kg) lowered mean arterial blood pressure by 19-3 mmHg, while after 6-OHD it fell only 9 4 mmHg. 4. These studies suggest that the central hypotensive effect of clonidine is dependent on the integrity of central monoaminergic neurones.

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“…) injection of ,B-adrenoceptor blocking agents induces bradycardia in cats (Kelliher & Buckley, 1970), dogs (Srivastava, Kulshrestha, Singh & Bhargava, 1972), rabbits (Reid, Lewis, Myers & Dollery, 1974) and rats (Ito & Schanberg, 1974), whilst under the same experimental conditions, P-adrenoceptor stimulating drugs, especially isoprenaline, provoke tachycardia in dogs (Bhargava, Mishra & Tangri, 1972) cats (Gagnon & Melville, 1967) and rabbits (Toda, Matsuda & Shimamoto, 1969;Reid et al, 1974;Day & Roach, 1974a). …”

Section: Introductionmentioning

confidence: 99%

“…However, fl-blocking drugs and isoprenaline, when injected separately i.c.v., induce a fall in blood pressure (Toda et al, 1969;Kelliher & Buckley, 1970;Schmitt & Fenard, 1971;Srivastava et al, 1972;Reid et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Β‐adrenoceptor Blocking Drugs and Isoprenaline: Central Effects on Cardiovascular Parameters

Cohen

Lindenbaum

Midol-Monnet

et al. 1979

British J Pharmacology

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1 The central hypotensive activity of (+)-and (-)-propranolol (100 ig), pindolol (100 ig) and isoprenaline (1 and 4 pg) injected intracerebroventricularly (i.c.v.) was studied in rats anaesthetized with urethane and chloralose. Blood pressure, cardiac output and heart rate were measured; systolic stroke volume and peripheral vascular resistance were calculated. 2 (+)-and (-)-Propranolol and pindolol induced a fall of blood pressure but (+)-propranolol was less active. The heart rate was reduced more by (-)-propranolol than by (+)-propranolol or (-)-pindolol. The decrease of systolic stroke volume was greater for (-)-propranolol and pindolol than for (+)-propranolol. Peripheral vascular resistance was reduced to the same level but with different time courses, (-)-propranolol having a longer effect than (+)-propranolol and pindolol. 3 Isoprenaline induced a hypotensive effect, while cardiac output and heart rate increased; the systolic stroke volume remained stable but peripheral vascular resistance was significantly decreased. 4 These results suggest that different central regulatory centres are involved in the control of cardiac function and peripheral vascular tone.

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Cardiovascular effects of sympathomimetic amines injected into the cerebral ventricles of rabbits

Cited by 36 publications

References 13 publications

Effect of intraventricular injection of transmitter substances and temperature on autonomic functions of conscious sheep.

Effect of intraventricular injection of transmitter substances and temperature on autonomic functions of conscious sheep.

Central noradrenergic neurones and the cardiovascular actions of clonidine in the rabbit

Β‐adrenoceptor Blocking Drugs and Isoprenaline: Central Effects on Cardiovascular Parameters

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