Cardiovascular effects of Teucrium polium L. extract in rabbit

Abstract

Background:Teucrium polium L. (TP) have been used in herbal medicine for different purposes such as antispasmodic, antidiabetic and lowering blood lipid. In the present study, the impact of aqueous-ethanol extract of TP on blood pressure, heart rate and intraventricular pressure was investigated in rabbit.Materials and Methods:Twenty-four NWZ rabbits weighed (2-3 kg) were randomly divided into four groups. In each experiment, two groups of six rabbits received jugular injection of either TP extract (20, 40 and 80 mg/kg) or normal saline for blood pressure effects and two groups for intraventricular pressure. Then, blood pressure, heart rate and intraventricular pressure were measured via carotid cannula using pressure transducer connected to a power lab system, and the data were pooled from independent, single-blinded experiments for each group.Results:Treatment with 80 mg/kg of TP extract significantly depressed the mean arterial blood pressure (12.5%, P< 0.05). However, there was no significant decrease in the 20 or 40 mg/kg dose or normal saline treatment group. Moreover, the extract increased (dp/dt)max (P<0.05), maximum left ventricular pressure (LVPmax) (P<0.05) and decreased (dp/dt)min significantly (P<0.05), there was no meaningful effect on left ventricular end-diastolic pressure (LVEDP).Conclusion:The present results demonstrated the extract had no effect on the heart rate, but showed a positive inotropic on the heart and hypotensive effects. These data suggested that hypotensive effect may counterbalance by the inotropic effect of the extract.

Ameliorative role of Teucrium polium extract on γ-radiation toxicity in brain of albino rats

“…Furthermore, the plant owns hypoglycemic, hypolipidemic, insulinotropic, antinociceptive, antioxidant, and anti-inflammatory properties (Gharaibeh et al, 1988;Tariq et al, 1989;rasekh et al, 2001;abdollahi et al, 2003;Couladis et al, 2003;Yazdanparast, 2004 andmousavi et al, 2012). Tp also affects the cardiovascular system (Niazmand et al, 2011), diminishes body weight (Suleiman et al, 1988), and protects against hepatotoxicity induced by acetaminophen (Kalantari et al, 2013). It has been demonstrated that Tp extract possesses antiamnesic properties in a mouse model of amnesia induced by scopolamine (Orhan & aslan, 2009).…”

Teucrium polium-induced vasorelaxation mediated by endothelium-dependent and endothelium-independent mechanisms in isolated rat thoracic aorta

“…NO and prostacyclin are endothelium-derived relaxing factors. [ 29 30 ] L-NAME as an inhibitor of NO production attenuated the relaxant effect of the extract at concentration of 1 mg/ml that shows the relaxant effect of the extract on this concentration is dependent to NO pathway.…”

“…These results support our previous study which demonstrated the hypotensive effect of TP extract. [ 30 ] Since TP extract showed inotropic and chronotropic effect,[ 27 30 ] it seems TP could be considered as a candidate for treatment of congestive heart failure as it is used traditionally in some parts of Iran.…”

“…and myrcene), and sesquiterpenes (germacrene D, β-caryophyllene, and spathulenol). [ 23 24 25 26 ] There is increasing evidence of cardiovascular effects of TP such as positive inotropic and chronotropic,[ 27 28 ] decreasing of blood pressure,[ 19 29 30 ] and lowering blood lipid. [ 31 ] However, the exact effect of TP extract on the vascular system has not been clarified.…”

Teucrium polium L. Improved Heart Function and Inhibited Myocardial Apoptosis in Isolated Rat Heart Following Ischemia-Reperfusion Injury

“…Then, it was left to dry at room temperature in a dry and dark room. 300 g of the plant was soaked in ethanol (50%) for 48 h. Then, it was evaporated and filtrated at 40°C for 72 h. The dried extract was dissolved in distilled water to make various concentrations 0.5, 1, and 2 mg/ml [ 14 , 16 ].…”