Cardiovascular effects of tyramine: Adrenergic and cholinergic interactions

Khwanchuea, Rapheeporn; Mulvany, Michael J.; Jansakul, Chaweewan

doi:10.1016/j.ejphar.2007.10.029

Cited by 22 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prominent BP profile and magnitude was that of atropine ( figure 4.44 a). Infusion of agonists was done 20 minutes after infusing atropine in most studies in which atropine was used to block the muscarinic receptors (Muntzel et al, 1997;Dimo et al, 2003;Delphine Holopherne et al, 2008;Khwanchuea et al, 2008;Lessa et al, 2008;Liu et al, 2008;Rattmann et al, 2008;Shirasaka et al, 2009;De Menezes et al, 2010). violacea were significantly (p < 0.05) higher than those observed with muscarine after pretreatment of animals with atropine.…”

Section: Does T Violacea Act By Blocking the Beta I Adrenoceptors?mentioning

confidence: 99%

“…Muscarine (2.5 µg/kg) was then infused into the same animal, after the BP and HR returned to the level prior to the infusion of the MLE. The drugs were infused 20 minutes after atropine infusion (Thán et al, 2000;Dimo et al, 2003;Dabire, 2004;Adami et al, 2006;Ajay et al, 2007; D. Holopherne et al, 2008;Khwanchuea et al, 2008;Lessa et al, 2008;Rattmann et al, 2008;De Menezes et al, 2010).…”

Section: D)mentioning

confidence: 99%

“…The associated reductions in HR were from 403.6 ± 9.0 bpm at baseline, to 401.6 ± 6.7 bpm, i.e., by 0.5 ± 1.5% (maximum effect of the Infusion ends lowest dose), and to 350.7 1 ± 2.9 bpm, i.e., by 13.1 ± 0.6% (maximum effect of the highest dose), and were only significant (p < 0.05) at the three highest doses given (figure 4.25 b). Prazosin is a specific antagonist of the α 1 adrenoceptor (Hui & Qiu, 1996;Dabire, 2004;Khwanchuea et al, 2008), and was used as the positive control in assessing the effect of the of 135.6 ± 7.0 mmHg, was only observed at the dose of 10.0 µg/kg (a 10.9 ± 2.9% increase to 150.4 ± 6.7 mmHg); and (c) MAP from the baseline value of 153.8 ± 6.4 mmHg, were observed at the doses of 5.0 µg/kg (an 8.6 ± 1.7% increase to 167.0 ± 5.4 mmHg) and 10.0 µg/kg (a 13.5 ± 2.6% increase to 174.6 ± 6.8 mmHg) ( figure 4.33 a). Dobutamine increased the HR in a dose-dependent manner from 394.0 ± 7.9 bpm at baseline, to 399.5 ± 7.2; i.e., by 1.4 ± 0.5% (maximum effect of lowest dose), and to 518.4 ± 8.3 bpm, i.e., by 31.6 ± 2.1%…”

Section: Effect Of Losartan (30 Mg/kg) On Bp and Hrmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

show abstract

Section: Does T Violacea Act By Blocking the Beta I Adrenoceptors?mentioning

confidence: 99%

Section: D)mentioning

confidence: 99%

Section: Effect Of Losartan (30 Mg/kg) On Bp and Hrmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…Although tyramine is not able to cross the blood-brain barrier [73], its effect appears to be transmitted via the afferent pathway in the central vagal pre-ganglionic neurons that regulate the pacemaker activity of the heart [74].…”

Section: Tyraminementioning

confidence: 99%

Toxicological Effects of Dietary Biogenic Amines

Ladero¹,

Calles-Enríquez²,

Fernández³

et al. 2010

CNF

450

294

View full text Add to dashboard Cite

Biogenic amines (BAs) are defined as low molecular weight organic bases with biological activity. They are formed and degraded as part of the normal metabolism of microorganisms, plants and animals, in which they have important physiological functions. In humans, BAs are involved in brain activity, the regulation of body temperature and stomach pH, gastric acid secretion, the immune response, and cell growth and differentiation etc. However, the consumption of foods with high concentrations of BAs can induce adverse reactions such as nausea, headaches, rashes and changes in blood pressure. The accumulation of BAs in the food matrix is mainly due to the presence of bacteria able to decarboxylate certain amino acids. The most common and powerful BAs found in food are histamine, tyramine and putrescine. Their contents vary, sometimes reaching over 2 g per kg. Histamine is the only BA for which

show abstract

“…Known cardiovascular active substances that have been isolated from stems of Tinospora crispa are cis-and trans-feruloyl tyramine (Fukuda et al, 1983), analogues of tyramine that mediate release of catecholamine from sympathetic nerves (Temma et al, 1991;Khwanchuea et al, 2008). Furthermore, our results demonstrate other unknown substances that are present at the peak 4 and 6 fractions from the HPLC chromatogram of the T. crispa extract (Fig.…”

Section: Constituents Of Tinospora Crispamentioning

confidence: 44%