Cardiovascular fat in women at midlife: effects of race, overall adiposity, and central adiposity. The SWAN Cardiovascular Fat Study

Hanley, Carrie; Matthews, Karen A.; Brooks, Maria M.; Janssen, İmke; Budoff, Matthew J.; Mulukutla, Suresh; Khoudary, Samar R. El

doi:10.1097/gme.0000000000000945

Cited by 12 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, GAT has a protective effect on obesity-related diseases. Like VAT, pericardial fat depots contribute to cardiovascular disease via IR and local release of adipocytokines within the heart [15,16].…”

Section: Pathophysiology Of Nafld and Variations In Adiposity Distributionmentioning

confidence: 99%

“…Findings from the Framingham and Jackson Heart studies provide insight into the differential contribution of VAT to cardiovascular morbidity in NHB and NHW women, with VAT exerting a less toxic effect among NHB women [44]. Thus, an obesity paradox has been described with the observation that NHBs possess less of the noxious VAT, lower triglycerides, and higher HDL cholesterol levels, but have higher prevalence of hypertension and T2DM [16,44,56].…”

Section: Racial/ethnic Disparities In Visceral Adiposity and Other Ectopic Depotsmentioning

confidence: 99%

See 1 more Smart Citation

Ethnic Disparities in Adiposity: Focus on Non-alcoholic Fatty Liver Disease, Visceral, and Generalized Obesity

et al. 2019

View full text Add to dashboard Cite

Purpose of Review Excessive adiposity has become a public health problem worldwide, contributing to the rise in obesity-related diseases and associated morbidity and mortality. This review details the relative significance of race/ethnicity as it pertains to adiposity and non-alcoholic fatty liver disease (NAFLD). Recent Findings Fat distribution remains a more reliable measure of adiposity than anthropometric measures, with visceral adipose tissue (VAT) associated with increased risk of cardiometabolic disease. While obesity is the most common risk factor for NAFLD, the racial/ethnic prevalence of obesity does not completely parallel NAFLD risk. Summary Combating racial/ethnic disparities in obesity requires understanding differential risk among various groups. Hispanics are disproportionally impacted by NAFLD and have high rates of obesity, VAT, and insulin resistance (IR). This contrasts with Blacks, who have high prevalence of obesity and IR, accompanied by a paradoxically favorable lipid profile and low prevalence of VAT and NAFLD. Many features of adiposity and NAFLD are mediated by genetic and environmental factors, the latter being modifiable and the focus of interventions.

show abstract

Section: Pathophysiology Of Nafld and Variations In Adiposity Distributionmentioning

confidence: 99%

Section: Racial/ethnic Disparities In Visceral Adiposity and Other Ectopic Depotsmentioning

confidence: 99%

Ethnic Disparities in Adiposity: Focus on Non-alcoholic Fatty Liver Disease, Visceral, and Generalized Obesity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, aorta length was estimated from table position number at first included CT slice and table position number at last included CT slice, and accounted for in multivariable analysis. Between and within reader Spearman correlation coefficients for PVAT were 0.99 indicating excellent reproducibility (23).…”

Section: Cardiovascular Fat Assessmentmentioning

confidence: 88%

Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study

Khoudary

Chen

Nasr

et al. 2019

The Journals of Gerontology: Series A

Self Cite

View full text Add to dashboard Cite

Background Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors. Methods Participants from the Study of Women’s Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 ± 0.7 years. Results Two hundred and seventy-six women (aged 51.3 ± 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 ± 0.21 m/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3–6.3%; p = .03). Conclusion Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.

show abstract

“…ese discrepancies could be partially explained by epidemiological aspects. First, central adiposity is regarded as an estimate of cardiometabolic risk factors in a variety of populations [32][33][34][35]. Second, it was well known that age, sex, smoking, and glucolipid metabolism are independent risk factors of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research

Zhou

et al. 2021

International Journal of Endocrinology

View full text Add to dashboard Cite

Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population. Methods. Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured. Results. Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel’s thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all p < 0.05 ). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all p < 0.05 ). Conclusions. These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.

show abstract

Cardiovascular fat in women at midlife: effects of race, overall adiposity, and central adiposity. The SWAN Cardiovascular Fat Study

Abstract: Racial differences were found in CF volumes and in their associations with adiposity measures among midlife women. Future research should determine how race-specific changes in CF volumes impact CHD risk in women.

Cited by 12 publications

References 32 publications

Ethnic Disparities in Adiposity: Focus on Non-alcoholic Fatty Liver Disease, Visceral, and Generalized Obesity

Ethnic Disparities in Adiposity: Focus on Non-alcoholic Fatty Liver Disease, Visceral, and Generalized Obesity

Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research

Contact Info

Product

Resources

About