Cardiovascular friendly natural products: a promising approach in the management of CVD

Abstract

Natural products play an important role as nutritional supplements and provide potential health benefits in cardiovascular diseases (CVD). Compiling data from experimental, epidemiological and clinical studies indicates that dietary nutrients have profound cardioprotective effects in the primary as well as secondary prevention of coronary heart disease, hence they are considered as cardiovascular friendly natural products. The mechanism of cardioprotection produced by dietary nutritional supplements such as flavonoids (citrus fruits, pulses, red wine, tea and cocoa), olive oil, omega-3 (omega-3) fatty acids (fish oil and fish-based products), lycopene (tomato and tomato-based products), resveratrol (grapes and red wine), coffee, and soy in the prevention and treatment of cardiovascular disorders have been discussed in the present review, with the emphasis of epidemiological and clinical studies. Based on the intriguing results of various studies, prophylactic and therapeutic potential of cardiovascular friendly natural products have been suggested. The supplementation of cardiovascular friendly natural products needs to be considered in all populations who have high prevalence of CVD.

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

“…It has a strong antioxidant property and has been shown to reduce the risk of cancer mainly breast, prostate and pancreas [21]. Lycopene also has protective effect in various chronic conditions like cardiovascular disease (CVD), coronary heart disease (CHD) and atherosclerosis [22,23]. Higher plasma lycopene concentrations are associated with lower risk of CVD in women which is mediated through regulation of cholesterol metabolism [24].…”

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

“…Increases glucose uptake by skeletal muscle cells in an AMPK-dependent manner [204]. Cardiovascular friendly [208]. Anti-atherogenic bioactivities; inhibiting monocyte-to-macrophage differentiation and foam cell formation as well as hypolipidemic activity via enhancing LDL receptor gene expression and activity and decreasing acyl CoA: diacylglycerol acyltransferase 2 expression in HepG2 liver cells [207] Alkaloids, flavonoids, cardiac glycosides, tannins, and saponin [200].…”

Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol

“…Interestingly, these may not be sufficiently robust or reliable as predictors of new cases of CVD (5,6) suggesting that protective factors exist that act to counteract and mitigate the deleterious consequences of the major CVD risk factors. In support of this possibility, recent data have shown that certain diet and dietderived chemicals may play a role in reducing and ameliorating the damage induced by exposure to risk factors of CVD (7)(8)(9)(10). Therefore, the discovery and identification of protective dietary factors and elucidation of the mechanisms by which they confer cardioprotection may be envisaged to shed light on new CVD management strategies.…”