Cardiovascular health: a global primordial need

Brant, Luísa Campos Caldeira; Ribeiro, Antônio Luiz Pinho

doi:10.1136/heartjnl-2017-312562

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…10 The American Heart Association has published national goals for cardiovascular health promotion and disease reduction, 87 and guidelines aligned with the concept of cardiovascular health are described. 13 Of course, attaining these goals of disease reduction relies heavily on a clearer understanding of CVD to better inform the path to follow when developing diagnostic and therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development

Vilches-Moure

2019

comp med

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Cardiovascular disease remains one of the top contributors to morbidity and mortality in the United States. Increasing evidence suggests that many processes, pathways, and programs observed during development and organogenesis are recapitulated in adults in the face of disease. Therefore, a heightened understanding of cardiac development and organogenesis will help increase our understanding of developmental defects and cardiovascular diseases in adults. Chicks have long served as a model system in which to study developmental problems. Detailed descriptions of morphogenesis, low cost, accessibility, ease of manipulation, and the optimization of genetic engineering techniques have made chicks a robust model for studying development and make it a powerful platform for cardiovascular research. This review summarizes the cardiac developmental milestones of embryonic chickens, practical considerations when working with chicken embryos, and techniques available for use in chicks (including tissue chimeras, genetic manipulations, and live imaging). In addition, this article highlights examples that accentuate the utility of the embryonic chicken as model system in which to study cardiac development, particularly epicardial development, and that underscore the importance of how studying development informs our understanding of disease.

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Section: Discussionmentioning

confidence: 99%

Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development

Vilches-Moure

2019

comp med

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“…7,21 While mass preventive strategies are more politically challenging, particularly in a scenario of low investment in health, they need to be combined with strategies focused on individuals at high CVR to improve the cardiovascular health of all Brazilians. 22…”

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confidence: 99%

Cardiovascular Risk in Women from a Quilombo Settlement: The Effect of Aggregated Vulnerabilities

Malta¹,

Brant²

2021

International Journal of Cardiovascular Sciences

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Cardiovascular risk (CVR) is a field of great relevance with a growing number of studies throughout the country due to the magnitude of cardiovascular diseases (CVD), which have caused nearly 18 million deaths in 2016 and represent 31% of worldwide deaths. [1][2][3] In Brazil, CVD also lead the mortality and disabilityadjusted life years (DALYs) rates, 4.5 with negative effects on the quality of life of individuals, family members, and societies. 3.5 It is noteworthy that CVD has an unequal effect on populations, with greater morbidity and mortality among low-income and least educated individuals. 6 In this context, it is important to identify the modifiable risk factors (RF) associated with CVD, such as behavioral (tobacco, alcohol, unhealthy diet, sedentarism) and metabolic RF (obesity, diabetes, hypertension, dyslipidemia); given that the risk of death from CVD attributable to metabolic RF is 74%, revealing great potential for prevention. 7,8

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“…In an editorial, Brant and Ribeiro7 emphasise that improving cardiovascular health (CVH) in low-income and middle-income countries requires that we ‘address the first step of the chain, which is to promote ideal CVH. If we want to pursue CVH, we need to keep the populations free from cardiovascular risk factors and thus invest in primordial prevention.…”

mentioning

confidence: 99%

Heartbeat: Causes and consequences of atrial fibrillation

Otto

2018

Heart

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Cardiovascular health: a global primordial need

Cited by 6 publications

References 7 publications

Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development

Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development

Cardiovascular Risk in Women from a Quilombo Settlement: The Effect of Aggregated Vulnerabilities

Heartbeat: Causes and consequences of atrial fibrillation

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