Cardiovascular Health Disparities in Underserved Populations

Mouton, Charles P.; Hayden, Michael; Southerland, Janet H.

doi:10.1016/j.cpha.2018.08.010

Cited by 4 publications

(4 citation statements)

References 164 publications

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“…These types of initiatives have proven effectiveness with respect to mortality and cost reduction [133]. While lifestyle and community interventions related to reducing the burden of type 2 DM [91][92][93][94], hypertension [134], and obesity [135] have been shown to be effective in women from racial/ethnic minority backgrounds, widespread incorporation of such initiatives is lacking [17]. Furthermore, effective interventions to address the femalespecific, pregnancy-related CV risk factors in minority women are needed [136][137][138][139][140] and represent a worthwhile target for improving outcomes in these patients.…”

Section: Cardiac Care For Women Beyond 2020mentioning

confidence: 99%

“…When considering racial/ethnic CVD prevalence, the highest CVD prevalence rates are among Black males (60.1%) and Black females (57.1%), while the lowest prevalence rates are among NH Asian males (47.4%) and NH Asian females (37.2%) [1]. Additionally, disparities in CVD diagnosis, treatment, and outcomes disproportionately affect individuals from racial/ethnic minority backgrounds [1,10,[16][17][18][19][20][21][22], and CVD disparities among women are amplified when they belong to minority racial/ethnic backgrounds.…”

Section: Introductionmentioning

confidence: 99%

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Disparities in Cardiovascular Care and Outcomes for Women From Racial/Ethnic Minority Backgrounds

Balla

Gomez

Rodríguez

2020

Curr Treat Options Cardio Med

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Purpose of review Racial, ethnic, and gender disparities in cardiovascular care are well-documented. This review aims to highlight the disparities and impact on a group particularly vulnerable to disparities, women from racial/ethnic minority backgrounds. Recent findings Women from racial/ethnic minority backgrounds remain underrepresented in major cardiovascular trials, limiting the generalizability of cardiovascular research to this population. Certain cardiovascular risk factors are more prevalent in women from racial/ethnic minority backgrounds, including traditional risk factors such as hypertension, obesity, and diabetes. Female-specific risk factors including gestational diabetes and preeclampsia as well as non-traditional psychosocial risk factors like depressive and anxiety disorders, increased child care, and familial and home care responsibility have been shown to increase risk for cardiovascular disease events in women more so than in men, and disproportionately affect women from racial/ethnic minority backgrounds. Despite this, minimal interventions to address differential risk have been proposed. Furthermore, disparities in treatment and outcomes that disadvantage minority women persist. The limited improvement in outcomes over time, especially among non-Hispanic Black women, is an area that requires further research and active interventions. Summary Understanding the lack of representation in cardiovascular trials, differential cardiovascular risk, and disparities in treatment and outcomes among women from racial/ethnic minority backgrounds highlights opportunities for improving cardiovascular care among this particularly vulnerable population.

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Section: Cardiac Care For Women Beyond 2020mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disparities in Cardiovascular Care and Outcomes for Women From Racial/Ethnic Minority Backgrounds

Balla

Gomez

Rodríguez

2020

Curr Treat Options Cardio Med

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“…In tandem, African Americans have higher rates of many stress-related CVD risk factors (Blankstein et al, 2011;Flegal, Carroll, Ogden, & Curtin, 2010). This includes hypertension -an especially potent CVD precursor (Mouton, Hayden, & Southerland, 2017). African Americans are likewise over-burdened by prehypertension (PHT) -a modifiable risk factor for hypertension and CVD that carries a considerable potential for intervention (Wang & Wang, 2004).…”

Section: Introductionmentioning

confidence: 99%

Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans

Woerner

Lucas

Pierce

et al. 2019

Psychoneuroendocrinology

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at Irvine. We wish to confirm that there are no other known potential conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property. We further confirm that any aspect of the work covered in this manuscript that has involved human participants has been conducted with the ethical approval of all relevant bodies. We understand that the Corresponding Author is the sole contact for the Editorial process (including Editorial Manager and direct communications with the office). He/she is responsible for communicating with the other authors about progress, submissions of revisions and final approval of proofs. We confirm that we have provided a current, correct email address which is accessible by the Corresponding Author.

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“…Coronary artery disease is the main cause of death and represents approximately 31% (17.7 million people) of all global deaths in 2015, as reported by the World Health Organization. A coronary stent is the most prevalent procedure for this disease . A conventional bare metal stent leads to in‐stent restenosis in approximately 30% of patients due to the excessive migration and proliferation of vascular smooth muscle cells .…”

Section: Introductionmentioning

confidence: 99%

Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re‐endothelialization of vascular stents

Kakinoki

Takasaki

Mahara

et al. 2017

J Biomedical Materials Res

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Rapid in-situ re-endothelialization of coronary stents is one of the most effective approaches to inhibit late thrombosis and restenosis. Strut surfaces allowing excellent adhesion and migration of endothelial cells and endothelial progenitor cells may accelerate in-situ re-endothelialization. Here, a well-known endothelial cell adhesive peptide, Arg-Glu-Asp-Val (REDV), was directly immobilized onto metallic surfaces by means of single-step tyrosine oxidation with copper chloride (II) and hydrogen peroxide, which we recently reported as a new biomaterial modification technique. REDV immobilization on a 316L stainless steel plate improved endothelial cell adhesion and effectively suppressed platelet adhesion in vitro. In addition, a Co-Cr stent immobilized with Ac-Tyr-Gly-Gly-Gly-Arg-Glu-Asp-Val (Y-REDV) was implanted into a rabbit abdominal aorta. On 7 days postimplantation, 80% of the strut surface of the Y-REDV-immobilized stent was covered by a thin neointimal layer and was similar in appearance to native endothelium. Restenosis and late thrombosis were not observed in the Y-REDV-immobilized stent for 42 days. These findings suggest that direct immobilization of Y-REDV peptide onto metallic biomaterials by tyrosine oxidation is effective for promoting in-situ re-endothelialization in vascular stents. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 491-499, 2018.

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Cardiovascular Health Disparities in Underserved Populations

Cited by 4 publications

References 164 publications

Disparities in Cardiovascular Care and Outcomes for Women From Racial/Ethnic Minority Backgrounds

Disparities in Cardiovascular Care and Outcomes for Women From Racial/Ethnic Minority Backgrounds

Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans

Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re‐endothelialization of vascular stents

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