Cardiovascular health profiles, systemic inflammation, and physical function in older adults: A population-based study

Fan, Dong; Chen, Xia; Fa, Wenxin; Liang, Xiaoyan; Han, Xiaolei; Wang, Yongxiang; Liu, Cong; Liang, Yajun; Welmer, Anna‐Karin; Hou, Tingting; Du, Yifeng; Qiu, Chengxuan

doi:10.1016/j.archger.2023.104963

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…3,21 Second, reduced physical function measurements are associated with increased inflammation and impaired immune function. 22,23 Chronic inflammation is a risk factor for both CVD and cancer, as it can promote the development and progression of these diseases. Third, weakness in physical function can be a sign of sarcopenia and age-related declines in physical function, increasing the risk of mortality from various causes, including CVD and cancer.…”

Section: Discussionmentioning

confidence: 99%

Optimal objective measurement of physical function and its predictive capacity for mortality among community‐dwelling older women

Luo,

Su,

Carter

et al. 2023

Geriatrics Gerontology Int

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AimObjective measurements of physcial function, including gait speed, handgrip strength, and the chair stand test, have been shown to have predictive capacity for negative health‐related outcomes. The aim of this study was to examine campariatively which of these common assessments may be optimal in terms of their predictive capacity for mortality.MethodsA total of 9834 community‐dwelling older women aged 65–89 years from the Study of Osteoporotic Fractures (SOF) were followed for 20 years. Gait speed, handgrip strength, and the chair stand test were measured every 2–4 years on up to 9 visits. All deaths were adjudicated.ResultsAll three measurements of physical function were significantly associated with overall, cardiovascular disease and other mortality. Gait speed had the greatest magnitude of hazard ratios (HRs) for all outcomes of interest. A one‐unit standard deviation increase in gait speed was associated with a 33% (HR = 0.67, 95% confidence interval [95% CI]: 0.64–0.70) lower risk for overall mortality, a 31% (HR = 0.69, 95% CI: 0.64–0.73) lower risk for cardiovascular disease mortality, a 15% (HR = 0.85, 95% CI: 0.78–0.92) lower risk for cancer mortality and a 42% (HR = 0.58, 95% CI: 0.55–0.62) lower risk for other mortality. Further examination of gait speed identified two cut‐points (0.9 and 0.7 m/s) that were strongly indicative of increased mortality risk.ConclusionOur large prospective study indicates that gait speed possesses a better prediction of mortality among older women compared with handgrip strength or the chair stand test. Using cut‐points of 0.9 and 0.7 m/s can help identify older women at higher mortality risk, who may benefit from physical function improvement interventions. Geriatr Gerontol Int 2023; ••: ••–••.

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Section: Discussionmentioning

confidence: 99%

Optimal objective measurement of physical function and its predictive capacity for mortality among community‐dwelling older women

Luo,

Su,

Carter

et al. 2023

Geriatrics Gerontology Int

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“…Gaye et al examined the mediating effect of in ammatory and hemostatic blood biomarkers in the association between baseline CVH and incident CVD and found that the association of behavioral CVH with incident coronary heart disease was partially mediated by high-sensitivity CRP, interleukin-6, and brinogen [34]. Fan et al explored the association of modi able CVH metrics with physical function in rural older adults in China and the potential role of in ammatory mechanisms in the association, and found that ideal CVH was signi cantly associated with higher scores on the balance, chair stand, and walking speed tests, and mediation analysis showed that serum interleukin-6 accounted for 14% of the association of CVH with the total Short Performance Physical Battery score and 10% of the association with the walking speed score [35]. Given the existing evidence that in ammation contributes to the pathophysiological process of OSA [14][15][16], it is reasonable to speculate that in ammation may also play a mediating role in the association between LS7 metrics and risk of OSA.…”

Section: Discussionmentioning

confidence: 99%

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Wu,

Yang,

Zhu

et al. 2023

Preprint

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Objectives We aimed to explore the impact of adherence to Life's Simple 7 (LS7) metrics on risk of obstructive sleep apnea (OSA), and the impact of inflammation on the association, in adults in the United States.Methods Data from 13,825 community-dwelling adults aged ≥ 20 years recruited in the National Health and Nutrition Examination Surveys (NHANES) 2005–2008, 2015–2018 was analyzed. The LS7 score was calculated based on the AHA definition of LS7 metrics. The diagnosis of OSA was based on self-reported symptoms of sleep disturbance using a standard questionnaire. The Multivariable Apnea Prediction (MAP) Index score was also calculated to assess the risk of OSA. Log-binominal regression and negative binomial regression were performed to estimate the associations between LS7 and OSA and MAP index, with odds ratios (ORs) and prevalence ratios (PRs) and their 95% confidence intervals (CIs) calculated. Mediation analysis was performed to estimate the mediating effects of inflammatory indicators on the associations.Results A total of 4473 participants (32.4%) had OSA, and the mean MAP index was 0.39. In fully adjusted log-binominal regression models, with total score < 6 as the reference, the ORs (95% CIs) for risk of OSA were 0.90 (0.73, 1.10), 0.76 (0.65, 0.89), 0.78 (0.64, 0.95), and 0.45 (0.38, 0.54) for total score = 6, total score = 7, total score = 8, and total score > 8, respectively (P for trend < 0.001). When LS7 score was analyzed as a continuous variable, each 1-point increase in LS7 score was associated with a 15% decrease in OSA risk (P < 0.001). In negative binominal regression models, the adjusted PRs (95% CIs) for the MAP index were 0.93 (0.90, 0.97), 0.87 (0.84, 0.91), 0.80 (0.77, 0.84), and 0.55 (0.53, 0.57) for total score = 6, total score = 7, total score = 8, and total score > 8, respectively (P for trend < 0.001). For each 1-point increase in LS7 score, the risk of OSA decreased by 13% (P < 0.001). Consistent results were observed in subgroup analysis. Mediation analysis indicated that inflammatory factors, including blood cell count, neutrophil count, and C-reactive protein, positively mediated the association of LS7 with OSA, with a mediation proportion of 0.022 (P = 0.04), 0.02 (P = 0.04), and 0.02 (P = 0.02), respectively.Conclusions In a nationally representative sample of US adults, adherence to LS7 metrics was independently associated with reduced OSA risk. Inflammation plays a mediating role in the association between LS7 and OSA.

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Association and prediction of Life's Essential 8 score, genetic susceptibility with MCI, dementia, and MRI indices: A prospective cohort study

Wang,

Yu,

Dong

et al. 2024

Journal of Affective Disorders

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Cardiovascular health profiles, systemic inflammation, and physical function in older adults: A population-based study

Cited by 5 publications

References 34 publications

Optimal objective measurement of physical function and its predictive capacity for mortality among community‐dwelling older women

Optimal objective measurement of physical function and its predictive capacity for mortality among community‐dwelling older women

Association between adherence to Life’s Simple 7 metrics and risk of obstructive sleep apnea among adults in the United States

Association and prediction of Life's Essential 8 score, genetic susceptibility with MCI, dementia, and MRI indices: A prospective cohort study

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