Cardiovascular images: vascular hamartoma of the mitral valve in a horse

DiVincenzo, Mallory J.; Bonagura, John D.; Rings, Lindsey M.; Burns, T.A.; Cianciolo, Rachel E.; Kohnken, Rebecca

doi:10.1016/j.jvc.2018.09.002

Cited by 3 publications

(4 citation statements)

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“…Teratomas are non-malignant neoplasms composed of the derivates of at least two of the embryonic layers: endoderm, mesoderm, and ectoderm (including neuroectoderm), exhibiting varying levels of maturation. In contrast, hamartomas are non-neoplastic proliferations of mature and well-differentiated tissue in an atypical anatomical location ( 12 ). These congenital lesions, less extensively documented than teratomas, include a limited number of cases describing ovarian hamartomas with an interstitial cell population in young foals or mares ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Findings in ovaries development from an aborted equine fetus

Cuccato,

Bertuglia,

Divari

et al. 2024

Front. Vet. Sci.

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An aborted female foal was submitted for necropsy. During the gross examination, the ovaries were pale, grayish, and enlarged (6 × 5 cm), with a well-developed vascular structure surrounding the external surface; the cut surface of the ovaries showed a brownish parenchyma with white follicular areas mainly localized in the peripheral region. The ovaries were fixed for histological investigations. The histological evaluation of the ovaries showed polygonal-shaped cells with abundant cytoplasm and round or oval nuclei, arranged in cords of single cells. The tissue architecture was characterized by the presence of lobular-like tissues with a central vein. The tissue mimicking hepatocytes was delimited by a mature fibrous tissue and was surrounded by the normal ovarian tissue characterized by germinal epithelium and primordial follicular structures. Based on the histological findings, a diagnosis of bilateral ovarian hamartoma was carried out initially. For a better characterization of the ovarian tissue, the expression of tissue-specific (liver and ovary) markers was investigated using immunohistochemistry. Following the immunohistochemical analysis, the hamartoma diagnosis was excluded. The ovaries exhibited unique characteristics different from those of adult horse ovaries as well as unique morphological features different from other mammalian species. This case report enhances our understanding of ovaries at a later stage of pregnancy and unveils unique characteristics of horse ovaries development, avoiding misdiagnosis with pathological findings, hamartomas, or neoplasia.

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Section: Introductionmentioning

confidence: 99%

Case report: Findings in ovaries development from an aborted equine fetus

Cuccato,

Bertuglia,

Divari

et al. 2024

Front. Vet. Sci.

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“…31 Vascular hamartoma is a non-neoplastic proliferation of disorganized, but well-differentiated vasculature, forming a focal developmental abnormality. 7 The focal growth of vascular hamartomas within the tissue of origin supports a diagnosis of a malformation over a true neoplasm. 23 The term vascular hamartoma is widely used in veterinary medicine and is also referred to as vascular malformation in human pathology.…”

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“…26 Vascular hamartomas reported in the veterinary literature have had secondary effects caused by local obstruction or compression of the adjacent anatomic structures, making them clinically relevant, benign lesions. 7 Vascular hamartomas have been reported in dogs, cats, horses, cows, and rats, in several anatomic locations including the skin, CNS, heart, and genitourinary tract. 24 Vascular hamartoma from the scrotum in dogs is a wellcharacterized benign lesion, comprised of single or multifocal proliferations of lobules of capillaries surrounding larger central vessels, with absent atypia and rare mitoses.…”

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Unilateral vascular hamartomas of the vaginal tunic in a dog

Barrantes Murillo,

Newsom,

Edwards

et al. 2023

J VET Diagn Invest

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A 12-y-old, male Dachshund was presented for elective orchiectomy. The testes were of normal size. The left testis had numerous dark-red, blood clot–like foci within the vaginal tunic over the pampiniform plexus, epididymis, and testis. Histologically, the red foci were limited to the vaginal tunic and consisted of disorderly growing, variably sized, thin-walled blood vessels lined by a single layer of endothelial cells without mitoses and supported by a thin layer of pericytes. The blood vessels were distended by erythrocytes without thrombus formation. Endothelial cells had cytoplasmic immunolabeling for CD31; pericytes had strong cytoplasmic immunolabeling for α–smooth muscle actin. Our case of subclinical unilateral vascular hamartomas of the vaginal tunic in a dog has not been reported previously in domestic animals or humans, to our knowledge.

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