Cardiovascular Imaging in Stress Cardiomyopathy (Takotsubo Syndrome)

Zghyer, Fawzi; Botheju, Welathanthrige Savindu Pasan; Kiss, Joshua E.; Michos, Erin D.; Corretti, Mary C.; Mukherjee, Monica; Hays, Allison G.

doi:10.3389/fcvm.2021.799031

Cited by 7 publications

(2 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early evidence suggests that rMS may be more commonly associated with a higher prevalence of comorbidities, adverse events, and certain biochemical changes, but this data remains mixed [ 11 , 12 ]. Its prognostic and clinical significance otherwise are unknown [ 13 ]. Its pathogenesis may be similar to takotsubo cardiomyopathy, which is frequently attributed to a catecholamine surge in the setting of a physical or emotional stressor.…”

Section: Discussionmentioning

confidence: 99%

A Case of Reverse McConnell’s Sign Associated With Acute Respiratory Distress Syndrome and Septic Shock

Curtis,

Ha,

Xie

et al. 2024

Cureus

View full text Add to dashboard Cite

We present a case of reverse McConnell’s sign, a rare echocardiographic finding of right ventricular apical hypokinesis and basal hyperkinesis, in a patient with acute respiratory distress syndrome and septic shock. Although multiple etiologies were hypothesized, providers attributed this cardiomyopathy to increased right heart afterload from hypoxic pulmonary vasoconstriction. Cardiac function normalized as the patient's respiratory failure and sepsis resolved. This study highlights the value of early echocardiography to help guide management in critical illness. In our case, this finding helped initiate diuresis and establish a baseline for monitoring cardiac function as this patient's critical illness resolved. Literature has most commonly associated reverse McConnell’s sign with massive pulmonary embolism and, more rarely, takotsubo cardiomyopathy. Given the absence of PE, takotsubo, or other identifiable cause, this case suggests that reverse McConnell’s sign may more generally indicate acutely increased right ventricular afterload rather than a specific diagnosis. When reverse McConnell’s sign is detected, treatment should focus on reversible causes of elevated right heart pressure (e.g., volume overload, PE) and increased pulmonary resistance.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case of Reverse McConnell’s Sign Associated With Acute Respiratory Distress Syndrome and Septic Shock

Curtis,

Ha,

Xie

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Up to 12.5-25% of cases with TTS may have left ventricular outflow tract (LVOT) obstruction, which is identified by echocardiogram (significant if peak instantaneous LVOT gradient ≥ 30 mmHg). It may be caused by basal hypercontractility with or without systolic anterior motion (SAM) of the anterior mitral leaflet, resulting in dynamic obstruction of the LVOT [111]. SAM motion can cause leaflet malcoaptation, which can lead to secondary mitral regurgitation (MR) in addition to the dynamic intraventricular obstruction.…”

Section: Echocardiographymentioning

confidence: 99%

Takotsubo Syndrome and Coronary Artery Disease: Which Came First—The Chicken or the Egg?

Celeski,

Nusca,

De Luca

et al. 2024

JCDD

View full text Add to dashboard Cite

Takotsubo syndrome (TTS) is a clinical condition characterized by temporary regional wall motion anomalies and dysfunction that extend beyond a single epicardial vascular distribution. Various pathophysiological mechanisms, including inflammation, microvascular dysfunction, direct catecholamine toxicity, metabolic changes, sympathetic overdrive-mediated multi-vessel epicardial spasms, and transitory ischemia may cause the observed reversible myocardial stunning. Despite the fact that TTS usually has an acute coronary syndrome-like pattern of presentation, the absence of culprit atherosclerotic coronary artery disease is often reported at coronary angiography. However, the idea that coronary artery disease (CAD) and TTS conditions are mutually exclusive has been cast into doubt by numerous recent studies suggesting that CAD may coexist in many TTS patients, with significant clinical and prognostic repercussions. Whether the relationship between CAD and TTS is a mere coincidence or a bidirectional cause-and-effect is still up for debate, and misdiagnosis of the two disorders could lead to improper patient treatment with unfavourable outcomes. Therefore, this review seeks to provide a profound understanding of the relationship between CAD and TTS by analyzing potential common underlying pathways, addressing challenges in differential diagnosis, and discussing medical and procedural techniques to treat these conditions appropriately.

show abstract

Presumed Takotsubo syndrome is associated with high in-hospital mortality in very elderly frail females: a case series

et al. 2023

View full text Add to dashboard Cite

Cardiovascular Imaging in Stress Cardiomyopathy (Takotsubo Syndrome)

Cited by 7 publications

References 90 publications

A Case of Reverse McConnell’s Sign Associated With Acute Respiratory Distress Syndrome and Septic Shock

A Case of Reverse McConnell’s Sign Associated With Acute Respiratory Distress Syndrome and Septic Shock

Takotsubo Syndrome and Coronary Artery Disease: Which Came First—The Chicken or the Egg?

Presumed Takotsubo syndrome is associated with high in-hospital mortality in very elderly frail females: a case series

Contact Info

Product

Resources

About