Cardiovascular imaging Noninvasive assessment of cerebral artery stenoses from anatomic computed tomography angiography

Qi, Xiaolong; Zhou, Fangyu; Wu, Jun; Zhou, Lin; Xu, Wei; Cheng, Juan; Yu, Mengxiao; Ma, Wanrong; Ji, Wenbin; Chen, Yang

doi:10.5114/pwki.2014.41461

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…12,13 In comparison with the CFD methods applied in the assessment of coronary artery stenosis, we believe that these preliminary attempts of using numerical methods for cerebrovascular diseases can be greatly improved. 12,14 In this study, we intended to achieve the goal by (1) considering anatomic models of full anterior or posterior circulation with primary collaterals included, (2) applying an instantaneous pulsatile inflow, and (3) incorporating a lumped parameter model to mimic the downstream effects from the distal vessels on the outlet boundaries. Instead of inducing cerebral hyperemia in patients and measuring FFR (the risk of hyperemic stimuli in cerebral artery is unclear), we measured the invasive and non-invasive fractional pressure ratios (FPR and FPR CFD ) using pressure wires and the improved CFD model, respectively.…”

Section: Introductionmentioning

confidence: 99%

Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics

Liu

Yan

et al. 2016

J Cereb Blood Flow Metab

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The fractional pressure ratio is introduced to quantitatively assess the hemodynamic significance of severe intracranial stenosis. A computational fluid dynamics-based method is proposed to non-invasively compute the FPR and compared against fractional pressure ratio measured by an invasive technique. Eleven patients with severe intracranial stenosis considered for endovascular intervention were recruited and an invasive procedure was performed to measure the distal and the aortic pressure ( P and P). The fractional pressure ratio was calculated as [Formula: see text]. The computed tomography angiography was used to reconstruct three-dimensional (3D) arteries for each patient. Cerebral hemodynamics was then computed for the arteries using a mathematical model governed by Navier-Stokes equations and with the outflow conditions imposed by a model of distal resistance and compliance. The non-invasive [Formula: see text], [Formula: see text], and FPR were then obtained from the computational fluid dynamics calculation using a 16-core parallel computer. The invasive and non-invasive parameters were tested by statistical analysis. For this group of patients, the computational fluid dynamics method achieved comparable results with the invasive measurements. The fractional pressure ratio and FPR are very close and highly correlated, but not linearly proportional, with the percentage of stenosis. The proposed computational fluid dynamics method can potentially be useful in assessing the functional alteration of cerebral stenosis.

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Section: Introductionmentioning

confidence: 99%

Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics

Liu

Yan

et al. 2016

J Cereb Blood Flow Metab

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“…As there is a CT FFR assessment of coronary arteries, respectively, a CT FFR of the carotid arteries is underway [ 47 ].…”

Section: Functional Assessment Of Intermediate Cerebral Stenosismentioning

confidence: 99%

Functional Assessment of Intermediate Vascular Disease

Yaneva-Sirakova

Serbezova

Vassilev

2018

BioMed Research International

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Interventional treatment in various vascular beds has advanced tremendously. However, there are several problems to be considered. We searched the literature and tried to analyze major parts of it. One is safety and applicability of coronary proven methods in other vascular beds. An unresolved problem is the functional assessment of intermediate lesions, as far as various target organs have quite different circulation from the coronary one and the functional tests should be modified in order to be applicable and meaningful. In the majority of the acute vascular syndromes, the culprit lesion is of intermediate size on visual assessment. On the other hand, a procedurally successfully managed high-degree stenosis is not always followed by clinical and prognostic benefit. In vascular beds, where collateral network naturally exists, the readings from the functional assessment are complicated and thus the decision for interventional treatment is even more difficult. Here come into help the functional assessment and imaging with IVUS, OCT, high-resolution MRI, and contrast enhanced CT or SPECT. The focus of the current review is on the functional assessment of intermediate stenosis in other vascular beds, unlike the coronary arteries.

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Physiome approach for the analysis of vascular flow reserve in the heart and brain

Lee

Ryu

Shin

et al. 2017

Pflugers Arch - Eur J Physiol

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This work reviews the key aspects of coronary and neurovascular flow reserves with an emphasis on physiomic modeling characteristics by the use of a variety of numerical approaches. First, we explain the definition of fractional flow reserve (FFR) in coronary artery and introduce its clinical significance. Then, computational researches for obtaining FFR are reviewed, and their clinical outcomes are compared. In the case of cerebrovascular reserve (CVR), in spite of substantial progress in the simulation of cerebral hemodynamics, only a few computational studies exist. Thus, we discuss the limitations of CVR simulation study and suggest the challenging issue to overcome these. Also, the future direction of physiomic researches for the flow reserves in coronary arteries and cerebral arteries is described. Also, we introduce a machine learning algorithm trained by the existing physiomic simulation data of flow reserve and suggest a prospective research direction related to this.

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Cardiovascular imaging Noninvasive assessment of cerebral artery stenoses from anatomic computed tomography angiography

Cited by 3 publications

References 10 publications

Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics

Functional assessment of cerebral artery stenosis: A pilot study based on computational fluid dynamics

Functional Assessment of Intermediate Vascular Disease

Physiome approach for the analysis of vascular flow reserve in the heart and brain

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