Cardiovascular impact of intravenous caffeine in preterm infants

Huvanandana, Jacqueline; Thamrin, Cindy; McEwan, Alistair; Hinder, Murray; Tracy, Mark

doi:10.1111/apa.14382

Cited by 20 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DFA1 has not previously been studied in infants with CCHD. Researchers have reported significant reductions in DFA1 in premature infants during conditions that would be expected to increase sympathetic responses, such as following delivery of loading doses of caffeine (Huvanandana, Thamrin, McEwan, Hinder, & Tracy, 2018) and rewarming following therapeutic hypothermia (Massaro et al, 2017). Findings of DFA1 trajectories in cardiac-SSC infants similar to TD infants support further studies with sufficient sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease

Harrison

Chen

Stein

et al. 2019

Biological Research For Nursing

View full text Add to dashboard Cite

Background: Infants with complex congenital heart disease (CCHD) often develop neurodevelopmental disabilities. Cognitive abilities are associated with vagally mediated autonomic function. Skin-to-skin contact (SSC) interventions enhance infant neurodevelopment and autonomic function in other high-risk populations. Aim: To examine the effects of a neonatal SSC intervention on learning and autonomic function in 3-month-old infants: infants with CCHD who received neonatal SSC ( n = 10), typically developing (TD) infants ( n = 16), and infants with CCHD without SSC ( n = 10). Methods: This secondary data analysis measured cognitive function using the mobile paradigm (MP), a classic measure of learning based on operant conditioning. Autonomic function was assessed with heart rate (HR) and HR variability (HRV). Data were analyzed with repeated-measures general linear mixed modeling with α = .10 for this exploratory study. Results: Learning rates were TD = 75%, cardiac-SSC = 70%, and cardiac-control = 40%. Learners demonstrated significant reductions in HRV during the MP; nonlearners exhibited no change. TD and cardiac-SSC groups exhibited increases in HR and reductions in HRV during the MP. No significant changes occurred in the cardiac-control group. Nonlinear HRV during the MP differed only in the TD group. Conclusions: Findings suggest improvements in cognitive and autonomic development in 3-month-old infants with CCHD who received neonatal SSC. Learning and autonomic function results in infants with CCHD who had not received SSC suggest reduced capacity to muster the physiologic resources to carry out this cognitive task. Findings provide preliminary evidence in support of implementation of SSC with infants with CCHD and support additional research.

show abstract

Section: Discussionmentioning

confidence: 99%

Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease

Harrison

Chen

Stein

et al. 2019

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…Our results regarding the effect of caffeine on HR and HRV are in accordance with the study of Ulanovsky et al who also didn't show any impact of caffeine (applied in a loading dose 15-20 mg/kg/day, followed by a maintenance dose of 5-10 mg/kg/day) either on the HR or HRV in premature newborns. Yet, their sample may not be comparable to ours, as the newborns in their study [1] as well as in Huvanandana's [3] were younger than our newborns (gestational age 30.3 ± 2.5 weeks and 27.0 (23.6-33.3) weeks compared to 34 ± 5 weeks in our study) and also had signi cantly lower birth weight (1397 ± 458 g and 934 (552-2100) g compared to 2353 ± 914 g in our study) [1,3]. On the other hand, Huvanandana et al who compared the results of the linear and non-linear measurements of HRV in preterm newborns prior to and two hours after a loading caffeine dose, reported an increased HRV after caffeine administration when using non-linear, but not when using linear modelling, as it was analysed in our study.…”

Section: Discussionmentioning

confidence: 73%

“…On the other hand, Huvanandana et al who compared the results of the linear and non-linear measurements of HRV in preterm newborns prior to and two hours after a loading caffeine dose, reported an increased HRV after caffeine administration when using non-linear, but not when using linear modelling, as it was analysed in our study. They suspected that linear metrics might not adequately capture potentially altered dynamics in the HR control [3]. Moreover, the in uences of caffeine on the heart and the activity of ANS seem controversial as caffeine has also been shown to increase the HF component of HRV in adults, apparently increasing PNS activity [21,27].…”

Section: Discussionmentioning

confidence: 99%

“…Caffeine stimulates the respiratory centre in the central nervous system, thus increasing breathing frequency (BF) and tidal volume, improves the breathing pattern, and increases the blood ow rate in the pulmonary circulation [2]. It also affects the cardiovascular system (CVS): in the heart, it increases the heart rate (HR), cardiac contractility and stroke volume, consequently increasing cardiac output and mean arterial blood pressure [2,3]. As for the vascular system, caffeine exerts vasodilative effects in the pulmonary and most vessels of the systemic circulation but induces vasoconstriction in the cerebral circulation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Caffeine on the Heart Rate Variability in Newborns

Fister

Lenasi

Rihar

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Neonatal apnoea has been treated with caffeine, which affects the central nervous and the cardiovascular system. Heart rate variability (HRV) reflects the activity of the autonomic nervous system (ANS), and might be used as a measure of ANS maturation in newborns. We aimed to establish the effect of caffeine on HRV in newborns, and saught for a potential correlation between HRV and the postmenstrual age.Methods: In 25 newborns, hospitalized due to apnoea and treated with caffeine (2.5 mg/kg), we assessed breathing frequency, arterial oxygen saturation, body temperature, and the heart rate while they were sleeping in two bed positions (0° tilt and 30° head-up tilt). We assessed HRV by spectral analysis using fast Fourier transformation. The same protocol was reapplied 100 hours after caffeine withdrawal to assess control parameters.Results: Caffeine increased breathing frequency (p=0.023), but did not affect any other parameter assessed including HRV. We established a positive correlation between postmenstrual age and HRV during treatment with caffeine in a 30° head-up tilt position (total power: p=0.044; low-frequency band: p=0.039).Conclusions: Apparently, the maintenance dose of caffeine is too low to affect heart rate and HRV. A positive correlation between postmenstrual age and HRV might reflect maturation of ANS.Trial registration: NCT04869176, retrospectively registered on April 27th 2021.

show abstract

“…In another study, Huvanandana et al. evaluated the cardiovascular impact of intravenous caffeine and found that caffeine was likely to increase the responsiveness of the autonomic nervous system. Meanwhile, Seppä‐Moilanen et al.…”

Section: Caffeine and The Neonatal Heart And Lungsmentioning

confidence: 99%

Highlights in this issue

Käll¹,

Lagercrantz²

2019

Acta Paediatrica

View full text Add to dashboard Cite

Many seemingly healthy children show signs of metabolic syndromeMore than a quarter of otherwise healthy six-year-old Swedish children may have metabolic risk factors that increase their risk for cardiovascular disease. This finding comes from a longitudinal study that was conducted in Halland, south-west Sweden, by Kjellberg et al. (1). They found that 26% of the 212 children in the study had abnormal metabolic profiles, including insulin resistance. Jan Gustafsson (2) comments on the findings.

show abstract

Cardiovascular impact of intravenous caffeine in preterm infants

Cited by 20 publications

References 32 publications

Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease

Neonatal Skin-to-Skin Contact: Implications for Learning and Autonomic Nervous System Function in Infants With Congenital Heart Disease

The Effect of Caffeine on the Heart Rate Variability in Newborns

Highlights in this issue

Contact Info

Product

Resources

About