Cardiovascular magnetic resonance in the evaluation of heart failure

Assomull, Ravi; Pennell, Dudley J.; Prasad, Sanjay

doi:10.1136/hrt.2003.025304

Cited by 37 publications

(14 citation statements)

References 35 publications

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“…We recognize that not all non-ischemic cardiomyopathy patients will necessarily have visible fibrosis by LGE 37, 38. Therefore, we also made comparisons on patients with idiopathic cardiomyopathy from our previously study 39.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease

Broberg

Chugh

Conklin

et al. 2010

Circ: Cardiovascular Imaging

242

200

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Background-The etiology of ventricular dysfunction in adult congenital heart disease (ACHD) is not well understood.Diffuse fibrosis is a likely common final pathway and is quantifiable using MRI. Methods and Results-Patients with ACHD (nϭ50) were studied with cardiac MRI to quantify systemic ventricular volume and function and diffuse fibrosis. The fibrosis index for a single midventricular plane of the systemic ventricle was quantified by measuring T1 values for blood pool and myocardium before and after administration of gadolinium (0.15 mmol/kg) and then adjusted for hematocrit. Results were compared to healthy volunteers (normal controls, nϭ14) and patients with acquired heart failure (positive controls, nϭ4

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Section: Discussionmentioning

confidence: 99%

Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease

Broberg

Chugh

Conklin

et al. 2010

Circ: Cardiovascular Imaging

242

200

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“…Thus, only two of their eight patients meet the strict definition of PPCM. Five out of eight patients may better be classified as having hypertensive heart disease, a condition that typically does not display late gadolinium enhancement on MRI [11].…”

Section: Dear Sirmentioning

confidence: 99%

Characterisation of peripartum cardiomyopathy by cardiac magnetic resonance imaging

Ntusi

Chin

2008

Eur Radiol

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“…Previously, the occurrence of LGE has been linked to myocardial fibrosis 2,3. Late gadolinium enhancement has been found in infarcted areas in ischaemic heart disease due to fibrotic remodelling 4–7. Its role in non‐ischaemic cardiomyopathy remains controversial 8–10.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non‐ischaemic dilated cardiomyopathy

Alter

Rupp

Adams

et al. 2011

European J of Heart Fail

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AimsOccurrence of late gadolinium enhancement (LGE) as assessed by cardiac magnetic resonance (CMR) imaging has been attributed to various myocardial injuries. We hypothesized that LGE is associated with left ventricular (LV) wall stress. Methods and resultsWe examined 300 patients with suspected non-ischaemic dilated cardiomyopathy. Cardiac magnetic resonance was used to assess LV volume, mass, wall stress, and LGE. Increased LV end-diastolic wall stress (. 4 kPa) was found in 112 patients (37 %), and increased end-systolic wall stress (.18 kPa) in 121 patients (40%). Presence of LGE was observed in 93 patients (31%). End-diastolic (94 + 43 vs. 79 + 42 ml/m 2 , P ¼ 0.006) and end-systolic LV volumes (62 + 44 vs. 44 + 37 ml/m 2 , P , 0.001) and LV mass (95 + 34 vs. 78 + 31 g/m 2 , P , 0.001) were increased in patients exhibiting LGE. In particular, LV end-diastolic and end-systolic wall stress were increased (4.5 + 2.8 vs. 3.6 + 3.0 kPa, P ¼ 0.025; 19.6 + 9.1 vs. 17.5 + 8.2 kPa, P ¼ 0.045). Late gadolinium enhancement was observed more frequently than would be expected from random occurrence in patients with increased end-diastolic (39 vs. 26%, P ¼ 0.020) and end-systolic wall stress (41 vs. 24%, P ¼ 0.002). Both normal end-diastolic and end-systolic wall stress had a high negative predictive value for LGE (75 and 76%). ConclusionsThe present study shows that occurrence of LGE in cardiomyopathy is associated with increased LV wall stress and mass. Suspected causes are an increased capillary leakage by stretch, impaired contrast agent redistribution, or increased diffusion distances. It is proposed that LGE should be considered as a potential prognostic determinant of heart failure and severe arrhythmias.--

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Cardiovascular magnetic resonance in the evaluation of heart failure

Cited by 37 publications

References 35 publications

Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease

Quantification of Diffuse Myocardial Fibrosis and Its Association With Myocardial Dysfunction in Congenital Heart Disease

Characterisation of peripartum cardiomyopathy by cardiac magnetic resonance imaging

Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non‐ischaemic dilated cardiomyopathy

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