Cardiovascular malformations in congenital diaphragmatic hernia: Human and experimental studies

Migliazza, Lucia; Otten, Christian; Xia, Huimin; Rodrı́guez, José Ignacio; Díez-Pardo, Juan A.; Tovar, Juan A.

doi:10.1016/s0022-3468(99)90010-6

Cited by 85 publications

(73 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The similarities hold true with regard to the specific location and extent of diaphragmatic defects as well as the occurrence of associated anomalies affecting cardiac, pulmonary, and skeletal tissues [4,5].…”

Section: Introductionmentioning

confidence: 78%

The Activation of the Retinoic Acid Response Element Is Inhibited in an Animal Model of Congenital Diaphragmatic Hernia

et al. 2003

View full text Add to dashboard Cite

Defects very similar to those seen in infants born with congenital diaphragmatic hernias can be induced in rodents by the administration of the teratogen nitrofen. There is an interest in understanding the biochemical mechanisms of nitrofen’s actions in hopes of gaining insights into the etiology of congenital diaphragmatic hernia. In this study, we test the hypothesis that nitrofen is acting to perturb the retinoid signaling pathway by utilizing genetically engineered mice that have the lacZ reporter gene linked to a retinoic acid response element (RARE). We demonstrate a pronounced suppression of RARE-lacZ expression by nitrofen in vitro (by approximately 64%) and in vivo (by approximately 43%).

show abstract

Section: Introductionmentioning

confidence: 78%

The Activation of the Retinoic Acid Response Element Is Inhibited in an Animal Model of Congenital Diaphragmatic Hernia

et al. 2003

View full text Add to dashboard Cite

show abstract

“…31 Thus, it is conceivable that the safety margin for retinoic acid-mediated regulation of primordial diaphragm development is relatively low and thus more susceptible to perturbations compared with other tissues. Heart development is also particularly susceptible, as cardiac anomalies are observed in the rat model of nitrofen-induced CDH 5,6 and are the most commonly associated defect in infants with CDH. 33 RALDH2 is expressed in the developing lung 28 and its suppression by nitrofen could explain some of the abnormalities of lung development observed in the nitrofen model of CDH.…”

Section: Discussionmentioning

confidence: 99%

“…Further, the associated developmental defects observed with nitrofen-induced CDH such as skeletal and cardiac malformations are similar to those seen in a subpopulation of infants with CDH. [5][6][7] Data derived from studies of the nitrofen model suggest that the pathogenesis of CDH is linked to a malformation of the primordial diaphragm, the pleuroperitoneal fold. 8 However, the etiology of CDH is completely unknown.…”

Section: 2mentioning

confidence: 99%

Retinal Dehydrogenase-2 Is Inhibited by Compounds that Induce Congenital Diaphragmatic Hernias in Rodents

Mey¹,

Babiuk

Clugston

et al. 2003

The American Journal of Pathology

123

127

View full text Add to dashboard Cite

Currently, the etiology of the serious developmental anomaly congenital diaphragmatic hernia (CDH) is unknown. We have used an animal model of CDH to address this issue. We characterized four separate teratogens that produced diaphragmatic defects in embryonic rats that are similar to those in infants with CDH. We then tested the hypothesis that all these agents share the common mechanism of perturbing the retinoid-signaling pathway. Specifically, inhibition of retinal dehydrogenase-2 (RALDH2), a key enzyme necessary for the production of retinoic acid and that is expressed in the developing diaphragm, was assayed by measuring retinoic acid production in cytosolic extracts from an oligodendrocyte cell line. The following compounds all induce posterolateral defects in the rat diaphragm; nitrofen, 4-biphenyl carboxylic acid, bisdiamine, and SB-210661. Importantly, we demonstrate that they all share the common mechanism of inhibiting RALDH2. These data provide an important component of mounting evidence suggesting that the retinoid system warrants consideration in future studies of the etiology of CDH. Congenital diaphragmatic hernia (CDH) is a serious developmental disorder occurring in ϳ1 in 3000 live births in which the diaphragm muscle fails to form completely, resulting in a hole in the diaphragm and incomplete separation of the thoracic and abdominal cavities. Lung hypoplasia and pulmonary hypertension are major pathological consequences that account for much of the morbidity and mortality of this problem.

show abstract

“…A plausible aetiology of outflow tract and aortic arch abnormalities associated with CDH may be a disorder of neural crest cell migration to the aortic arches 11 . Left-sided CDH and liver herniation are also associated with functional left heart hypoplasia, possibly due to altered ductus venous flow and external compression by herniated abdominal organs 12 .…”

Section: Discussionmentioning

confidence: 99%

Konjenital diafragmatik herni ve aortik koarktasyon nadir birlikteliğinin prenatal tanısı

Akkurt¹,

Yavuz²,

Yalçın³

et al. 2017

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

View full text Add to dashboard Cite

AbstractÖz Congenital diaphragmatic hernia is a common thoracic abnormality with increased risk of associated abnormalities. The etiology of congenital diaphragmatic hernia is not exactly known and the plausible reason is the defect of the amuscular component of the primordial diaphragm. Although, fetal heart abnormalities are the most common associated abnormalities in fetuses with congenital heart defect, aortic coarctation is occurred rarely. We present a case with the prenatal diagnosis of the co-occurrence of congenital diaphragmatic hernia and aortic coarctation.Konjenital diafragmatik herni eşlik edebilecek diğer organ anomalileri riskinin arttığı, sık görülen bir toraks anomalisidir. Kesin etyolojisi bilinmemekle beraber, olası nedeni primordiyal diafragmanın amuskuler parçasındaki kusurdur. Konjenital diafragmatik hernili fetuslarda en sık birliktelik gösteren anomalisi kalp anomalisi olmakla beraber, aortic koarktasyon nadir görülmektedir. Bu olguda konjenital diafragma hernisi ve aortic koarktasyonu nadir birlikteliğinin prenatal tanısı sunulmuştur.

show abstract

Cardiovascular malformations in congenital diaphragmatic hernia: Human and experimental studies

Cited by 85 publications

References 18 publications

The Activation of the Retinoic Acid Response Element Is Inhibited in an Animal Model of Congenital Diaphragmatic Hernia

The Activation of the Retinoic Acid Response Element Is Inhibited in an Animal Model of Congenital Diaphragmatic Hernia

Retinal Dehydrogenase-2 Is Inhibited by Compounds that Induce Congenital Diaphragmatic Hernias in Rodents

Konjenital diafragmatik herni ve aortik koarktasyon nadir birlikteliğinin prenatal tanısı

Contact Info

Product

Resources

About