Cardiovascular medication burden in dementia disorders: a nationwide study of 19,743 dementia patients in the Swedish Dementia Registry

Čermáková, Pavla; Fereshtehnejad, Seyed‐Mohammad; Johnell, Kristina; Winblad, Bengt; Eriksdotter, Maria; Religa, Dorota

doi:10.1186/alzrt264

Cited by 29 publications

(33 citation statements)

References 65 publications

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“…The proportion of males was the highest within the youngest patients and was decreasing with advanced age, which is in line with a known pattern among HF patients . Female gender is more common in the general population of dementia patients, however, the predominant dementia disorder is AD, which is associated with female gender …”

Section: Discussionsupporting

confidence: 83%

“…They were older than HF patients and dementia patients in general. Patients with HF are on average 74 years old when they are registered into RiksSvikt and patients with dementia are on average 79 years old at the time of registration into SveDem …”

Section: Discussionmentioning

confidence: 99%

“…Patients with HF are on average 74 years old when they are registered into RiksSvikt 21 and patients with dementia are on average 79 years old at the time of registration into SveDem. 22 The majority of the patients were men (55%). The proportion of males was the highest within the youngest patients and was decreasing with advanced age, which is in line with a known pattern among HF patients.…”

Section: Characteristics Of Patientsmentioning

confidence: 98%

“…23 Female gender is more common in the general population of dementia patients, however, the predominant dementia disorder is AD, which is associated with female gender. 22 . Not surprisingly given the great age, the most common type of HF was HFPEF.…”

Section: Characteristics Of Patientsmentioning

confidence: 99%

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Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders

Čermáková

Lund

Fereshtehnejad

et al. 2015

European J of Heart Fail

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AimsHeart failure (HF) and dementia frequently coexist, but little is known about their types, relationships to each other and prognosis. The aims were to (i) describe patients with HF and dementia, assess (ii) the proportion of specific dementia disorders in types of HF based on ejection fraction and (iii) the prognostic role of types of HF and dementia disorders.Methods and resultsThe Swedish Heart Failure Registry (RiksSvikt) and The Swedish Dementia Registry (SveDem) were record-linked. Associations between dementia disorders and HF types were assessed with multinomial logistic regression and survival was investigated with Kaplan–Meier analysis and multivariable Cox regression. We studied 775 patients found in both registries (55% men, mean age 82 years). Ejection fraction was preserved in 38% of patients, reduced in 34%, and missing in 28%. The proportions of dementia disorders were similar across HF types. Vascular dementia was the most common dementia disorder (36%), followed by other dementias (28%), mixed dementia (20%), and Alzheimer disease (16%). Over a mean follow-up of 1.5 years, 76% of patients survived 1 year. We observed no significant differences in survival with regard to HF type (P = 0.2) or dementia disorder (P = 0.5). After adjustment for baseline covariates, neither HF types nor dementia disorders were independently associated with survival.ConclusionsHeart failure with preserved ejection fraction was the most common HF type and vascular dementia was the most common dementia disorder. The proportions of dementia disorders were similar across HF types. Neither HF types nor specific dementia disorders were associated with survival.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Patientsmentioning

confidence: 98%

Section: Characteristics Of Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders

Čermáková

Lund

Fereshtehnejad

et al. 2015

European J of Heart Fail

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“…Lewy body dementia (LBD) is the fourth most frequent cause of cognitive decline in the elderly [1] . It has frequently different associated pathological features of other neurodegenerative diseases that may contribute to a clinical symptom constellation [2] .…”

Section: Introductionmentioning

confidence: 99%

Detection of Cortical Microbleeds in Postmortem Brains of Patients with Lewy Body Dementia: A 7.0-Tesla Magnetic Resonance Imaging Study with Neuropathological Correlates

Reuck

Auger

Durieux³

et al. 2015

Eur Neurol

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Background: It is unclear whether associated cerebrovascular pathology contributes to the clinical spectrum of Lewy body dementia (LBD). Summary: The present postmortem 7.0-tesla MRI study investigates the anatomical distribution of cortical microbleeds (CoMBs) in LBD brains with and without associated Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). CoMBs predominated in the frontal section of the LBD brains and were associated to severe white matter lesions. No differences were observed when LBD brains with and without AD and CAA were compared. Key Messages: In LBD, there is a specific distribution of CoMBs that is different from that in other neurodegenerative diseases. The increase of frontal CoMBs is not due to the frequently associated AD and CAA features but due to the LBD itself.

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Comorbidity among inpatients with dementia: a preliminary cross-sectional study in West China

Xiao

Xiang

et al. 2023

Aging Clin Exp Res

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Objective To investigate comorbidities among hospitalized patients with dementia. Method Data were extracted from the discharge records in our hospital. Comorbidities based on ICD-10 were selected from the Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI). The distributions of these comorbidities were described in dementia inpatients and age- and sex-matched nondementia controls, as well as in inpatients with Alzheimer’s disease and vascular dementia. A logistic regression model was applied to identify dementia-specific morbid conditions. Results A total of 3355 patients with dementia were included, with a majority of 1503 (44.8%) having Alzheimer's disease, 395 (11.8%) with vascular dementia, and 441 (13.1%) with mixed dementia. The mean number of comorbidities was 3.8 in dementia patients (vs. 2.9 in controls). The most prevalent comorbidities in inpatients with dementia compared with those without dementia were cerebral vascular disease (73.0% vs. 35.9%), hypertension (62.8% vs. 56.2%), and peripheral vascular disease (53.7% vs. 31.2%). Comorbidities associated with dementia included epilepsy (OR 4.8, 95% CI 3.5–6.8), cerebral vascular disease (OR 4.1, 95% CI 3.7–4.5), depression (OR 4.0, 95% CI 3.2–5.0), uncomplicated diabetes (OR 1.5, 95% CI 1.4–1.7), peripheral vascular disease (OR 1.8, 95% CI 1.6–2.0), rheumatoid arthritis collagen vascular disease (OR 1.7, 95% CI 1.3–2.3), and anemia (OR 1.2, 95% CI 1.04–1.3). Some comorbidities suggested a protective effect against dementia. They were hypertension (OR 0.8, 95% CI 0.7–0.9), COPD (OR 0.6, 95% CI 0.5–0.6), and solid tumor without metastasis (OR 0.4, 95% CI 0.3–0.4). Vascular dementia has more cardiovascular and cerebrovascular comorbidities than Alzheimer's disease. Conclusion Patients with dementia coexisted with more comorbidities than those without dementia. Comorbidities (esp. cardio-cerebral vascular risks) in patients with vascular dementia were more than those in patients with AD. Specifically, vascular and circulatory diseases, epilepsy, diabetes and depression increased the risk of dementia. Supplementary Information The online version contains supplementary material available at 10.1007/s40520-023-02349-3.

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Cardiovascular medication burden in dementia disorders: a nationwide study of 19,743 dementia patients in the Swedish Dementia Registry

Cited by 29 publications

References 65 publications

Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders

Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders

Detection of Cortical Microbleeds in Postmortem Brains of Patients with Lewy Body Dementia: A 7.0-Tesla Magnetic Resonance Imaging Study with Neuropathological Correlates

Comorbidity among inpatients with dementia: a preliminary cross-sectional study in West China

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