Cardiovascular mortality following breast cancer treatment

Behavioral and Psychosocial Program Needs of Young Adult Cancer Survivors

“…This is particularly problematic, because young adult cancer survivors often face increased long-term physical and psychosocial risks. For example, many young adult survivors are at an increased risk of cardiovascular disease related to chemotherapy and/or radiation treatment (Ganz, Greendale, Petersen, Kahn, & Bower, 2003;Hooning, Aleman, Klijn, & van Leeuwen, 2004;King et al, 1996;van den Belt-Dusebout et al, 2006). Likewise, some young adult survivors face an increased risk of a second malignancy (Foss Abrahamsen et al, 2002;Shapiro & Recht, 2001;Travis et al, 2005).…”

Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries–Part C: Oxygen effect and its implications on high- and low-LET dose

“…Another inference from this work is that there is a greater risk of radiotherapy-induced vascular diseases in younger patients when irradiating the mediastinium, e.g., in the treatment of Hodgkin's disease (Boivin et al 1992) and breast cancer (Hooning et al 2004). This is due to the greater radiosensitivity of normal arteries compared to diseased arteries of the aged.…”

“…It is well established that cardiovascular disease (CVD) is one of the pathological changes from inadvertent inclusion of the heart when irradiating at relatively high doses the mediastinum for Hodgkin's disease (Boivin et al 1992) and breast cancer (Hooning et al 2004). In the latter study, cardiovascular mortality was increased 2.2 fold in patients who had radiotherapy for early stage breast cancer compared to non-irradiated patients.…”

Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries–Part A: Dose from radon and thoron

“…Similarly, the chronic low-dose exposure of nuclear power industry workers has been associated with circulatory disease (Cardis et al 1995) and arteriosclerotic heart disease (Howe et al 2004). Radiationinduced cardiovascular and other circulatory diseases have been observed in patients treated with radiation for ankylosing spondylitis, Hodgkin's disease, and breast cancer (Darby et al 1987, Boivin et al 1992, Hooning et al 2004). Studies of Japanese atomic-bomb survivors demonstrated a significant quadratic dose-response for the incidence of hypertension (Yamada et al 2004), whereas for heart disease, mortality rates showed strong evidence of a graded dose response with elevated risks in doses exceeding 0.5 Sv (Preston et al 2003).…”