Cardiovascular outcome associations among cardiovascular magnetic resonance measures of arterial stiffness: the Dallas heart study

Maroules, Christopher D.; Khera, Amit; Ayers, Colby; Goel, Akshay; Peshock, Ronald M; Abbara, Suhny; King, Kevin S.

doi:10.1186/1532-429x-16-33

Cited by 74 publications

(55 citation statements)

References 42 publications

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“…Therefore, patients with lesser aortic distensibility or increasing LV mass are more vulnerable to repetitive HD-induced cardiac ischemia (43,44). The preserved aortic distensibility over 12 months in the intervention group compared with significant reductions in the control group may have contributed to the observed cardiac effects (22,32). The interactions between intradialytic events and fluid/volume status are complex, and additional investigations are warranted to understand the mechanisms by which dialysate cooling might attenuate the progression of cardiomyopathy in patients on HD.…”

Section: Discussionmentioning

confidence: 99%

“…Aortic distensibility analysis is depicted in Figure 1, E and F as previously described (22). The ascending thoracic aortic area was manually traced using Jim version 6 (Xinapse software, UK) and graphically represented against time.…”

Section: Aortic Distensibilitymentioning

confidence: 99%

“…Recent studies determined that systolic strain and diastolic dysfunction predicted all-cause mortality or cardiovascular events in patients on HD with a normal EF (30,31). Both HD and non-HD population studies show that aortic distensibility independently predicts future cardiovascular events (22,32).…”

Section: Rationale For Study Outcomesmentioning

confidence: 99%

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Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients

Odudu

Eldehni

McCann

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Cardiovascular disease is the most common cause of death in patients on hemodialysis (HD). HD-associated cardiomyopathy is appreciated to be driven by exposure to recurrent and cumulative ischemic insults resulting from hemodynamic instability of conventionally performed intermittent HD treatment itself. Cooled dialysate reduces HD-induced recurrent ischemic injury, but whether this confers long-term protection of the heart in terms of cardiac structure and function is not known.Design, setting, participants, & measurements Between September 2009 and January 2013, 73 incident HD patients were randomly assigned to a dialysate temperature of 37°C (control) or individualized cooling at 0.5°C below body temperature (intervention) for 12 months. Cardiac structure, function, and aortic distensibility were assessed by cardiac magnetic resonance imaging. Mean between-group difference in delivered dialysate temperature was 1.2°C60.3°C. Treatment effects were determined by the interaction of treatment group with time in linear mixed models.Results There was no between-group difference in the primary outcome of left ventricular ejection fraction (1.5%; 95% confidence interval, -4.3% to 7.3%). However, left ventricular function assessed by peak systolic strain was preserved by the intervention (-3.3%; 95% confidence interval, -6.5% to -0.2%) as was diastolic function (measured as peak diastolic strain rate, 0.18 s 21 ; 95% confidence interval, 0.02 to 0.34 s 21 ). Reduction of left ventricular dilation was demonstrated by significant reduction in left ventricular end-diastolic volume (-23.8 ml; 95% confidence interval, -44.7 to -2.9 ml). The intervention was associated with reduced left ventricular mass (-15.6 g; 95% confidence interval, -29.4 to -1.9 g). Aortic distensibility was preserved in the intervention group (1.8 mmHg 21 310 23 ; 95% confidence interval, 0.1 to 3.6 mmHg 21 310 23 ). There were no intervention-related withdrawals or adverse events.

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Section: Discussionmentioning

confidence: 99%

Section: Aortic Distensibilitymentioning

confidence: 99%

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Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients

Odudu

Eldehni

McCann

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…[83,84] In addition, CMR may be used as an alternative technique to evaluate aortic stiffness, which is strongly related to systolic hypertension and is associated with future cardiovascular events. [85,86] Although sensitivity of CMR is high, the specificity is moderate for detecting major coronary artery lesions, and the availability and costs of CMR equipment currently limit large-scale use. [45] Another problem is the uncertainty of translating abnormal CMR findings observed at a young age to actual later-life CVD event risks, as longitudinal studies with sufficient follow-up time are not available.…”

Section: Coronary Artery Calcium Scorementioning

confidence: 99%

Determinants of future cardiovascular health in women with a history of preeclampsia

et al. 2015

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Please cite this article as: Zoet Gerbrand A, Koster Maria PH, Velthuis Birgitta K, de Groot Christianne JM, Maas Angela HEM, Fauser Bart CJM, Franx Arie, Rijn Bas B.van.Determinants of future cardiovascular health in women with a history of preeclampsia.Maturitas http://dx.doi.org/10.1016/j.maturitas. 2015.07.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Keywords:Preeclampsia, cardiovascular disease, risk assessment, screening, prevention Highlights  Female-specific risk factors, among which preeclampsia, may have additional value in cardiovascular screening.  Non-invasive imaging techniques can be helpful to detect early-stage cardiovascular lesions as a sign of subclinical atherosclerotic disease.  Preliminary studies show positive effects of short-term lifestyle interventions following preeclampsia.  There is a need for clinical practice guidelines that provide long-term strategies in women after preeclampsia in pregnancy to improve cardiovascular health. AbstractWomen who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life.However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk management. The aim of this review is to discuss the present knowledge on commonly used cardiovascular screening modalities available to women with a history of preeclampsia, and to discuss recent developments in early detection of CVD using cardiovascular imaging.Furthermore, we explore how female-specific risk factors may have additional value in cardiovascular screening, in particular in relatively young women, although their implementation in clinical practice is challenged by inconsistent results and lack of long-term outcome data. Non-invasive imaging techniques, e.g. coronary artery intima-media thickness (CIMT), can be helpful to detect subclinical atherosclerotic disease, and coronary artery calcium scoring (CACS) has shown to be effective in early detection of cardiovascular damage. However, whilst more short-term and long-term follow-up studies are becoming available, few studies have investigated women with a history of preeclampsia in the fourth and fifth decade of life, when early signs of premature CVD are most likely to become apparent.Further studies are needed to inform new and improved clinical practice guidelines, and provide longterm strategies to effectively prevent CVD, specifically targeted at women with a history of preeclampsia. Additionally, evaluation of feasibility, cost-effectiveness ...

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“…The predictive value of PWV has been assessed in a substudy of the Dallas Heart Study in 2122 healthy subjects with an 8-year follow-up period [3]. The study showed CMR-derived PWV to be associated with the occurrence of cardiovascular events and improved risk stratification when added to the Framingham Risk Score.…”

mentioning

confidence: 99%

Clinical value of pulse wave velocity: a promising marker for arterial stiffness

Amier

Nijveldt

2015

Neth Heart J

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recent non-invasive approach to measure PWV is by using cardiovascular magnetic resonance imaging (CMR). CMRderived PWV is more reliable, not limited by imaging planes, and CMR offers more possibilities regarding cardiovascular imaging (i.e. aortic anatomy, plaque visualisation and characterisation, cardiac function, carotid patency). Specifically regarding PWV, CMR also allows measurement of regional PWV in addition to global PWV, which will be discussed later. Moreover, CMR is increasingly implemented in routine clinical care and becoming more widely available.Through-plane velocity-encoded CMR at two (or more) sites perpendicular to the aorta is the most commonly used CMR technique for PWV assessment. The accuracy and reliability of CMR-based PWV assessment depends on temporal resolution, spatial sampling density and accurate ECG gating. There are several post-processing methods, but currently the time-to-foot method is used most often. After reconstruction of the waveform at each acquisition plane, the temporal shift (or transit time) between the waveforms is assessed using the foot of the waveforms: the intersection of a line fitted to the waveform upslope (through data points at 20 and 80 % of maximum velocity) with the horizontal axis or base velocity. Alternatively, the cross-correlation method has been suggested [1]; however, there is no consensus yet regarding a method of preference.In 2010, Westenberg et al.[2] validated two-directional in-plane velocity-encoded CMR and showed better correlation with the gold standard and better reproducibility than 'traditional' through-plane velocity-encoded CMR. With this technique flow velocity is assessed lengthwise in the aorta (from the candy cane view) as opposed to crosssectionally in the through-plane method. From the acquired images cross-sectional planes along the aortic centreline are defined, producing 200 waveforms from which PWV can be derived. By segmenting the aorta in a standardised fashPulse wave velocity (PWV) has emerged as a marker for arterial stiffness with a promising future role in cardiovascular risk stratification. The pressure wave produced by systolic pumping of the heart travels along the aorta and other vasculature throughout the body. With deterioration of the vessel wall, whether due to age, connective tissue disease or atherosclerosis, the transit time of the pulse wave from point A to B becomes shorter, meaning that PWV is directly related to the mechanical properties of the vessel. Cardiovascular disease leading to aortic dilatation typically occurs through a gradual process, although the clinical manifestation can be acute. Feared complications of aortic dilatation are dissection and rupture, with a high risk for mortality and morbidity. Indication for preventive surgical intervention is currently mostly based on aortic diameter. An added measure for detection of subclinical aortic disease is desirable for more tailored risk stratification to guide preventive intervention.Several methods are available for measuring PWV, all based...

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Cardiovascular outcome associations among cardiovascular magnetic resonance measures of arterial stiffness: the Dallas heart study

Cited by 74 publications

References 42 publications

Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients

Randomized Controlled Trial of Individualized Dialysate Cooling for Cardiac Protection in Hemodialysis Patients

Determinants of future cardiovascular health in women with a history of preeclampsia

Clinical value of pulse wave velocity: a promising marker for arterial stiffness

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