Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history

Akyea, Ralph Kwame; Iyen, Barbara; Georgiopoulos, Georgios; Kai, Joe; Qureshi, Nadeem; Ntaios, George

doi:10.1016/j.ejim.2022.12.006

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Previous studies have confirmed the correlation between MT and an unfavorable prognosis among patients with IS. Patients with comorbid MT and stroke are significantly younger, have more severe strokes on admission, infarctions occurring across various vascular regions of the brain, occurrences of deep vein thrombosis, coagulation disorders, and a higher risk of all causes mortality than that non-MT [ 6 , 8 , 21 ]. Cancer is associated with long-term mortality in young patients with stroke [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Malignant tumor increases the risk of all causes in-hospital mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database

Wang,

Fu,

Wang

2024

BMC Neurol

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Background Ischemic stroke (IS) and malignant tumor (MT) have high morbidity and mortality rates worldwide, and several associations exist between them. This study aimed to determine the effect of MT on hospital mortality in patients with IS. Methods Based on their MT status, participants with IS in the Medical Information Mart for Intensive Care IV (MIMIC-IV) were divided into two groups. The primary outcome was in-hospital all causes mortality. Kaplan-Meier survival analysis was performed to evaluate the intergroup in-hospital mortality, and three Cox regression models were used to determine the association between MT and in-hospital mortality. Results A total of 1605 participants (749 males and 856 females) were included in the study. The mean age was 72.030 ± 15.463 years. Of these, 257 (16%) patients died in the hospital. Kaplan-Meier analysis showed that the MT group had a significantly lower possibility of in-hospital survival than the non-MT group. In the unadjusted model, in-hospital mortality among MT patients had a higher odds ratio (OR) of 1.905 (95% CI, 1.320–2.748; P < 0.001) than the non-MT group. After adjusting for basic information, vital signs, and laboratory data, MT was also associated with increased in-hospital mortality (OR = 1.844, 95% CI: 1.255–2.708; P = 0.002). Conclusions Among the patients with IS, the risk of all causes in-hospital mortality was higher for MT than for patients non-MT. This finding can assist clinicians in more accurately assessing prognosis and making informed treatment decisions.

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Section: Discussionmentioning

confidence: 99%

Malignant tumor increases the risk of all causes in-hospital mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database

Wang,

Fu,

Wang

2024

BMC Neurol

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Recent cancer history and its impact on cardiovascular outcomes and mortality after an incident ischemic stroke

Kanazawa

Shimoda

Okamura

et al. 2023

European Journal of Internal Medicine

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Development and verification of a nomogram for predicting short-term mortality in elderly ischemic stroke populations

Jin

Zeng

et al. 2023

Sci Rep

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Stroke is a major healthcare problem worldwide, particularly in the elderly population. Despite limited research on the development of prediction models for mortality in elderly individuals with ischemic stroke, our study aimed to address this knowledge gap. By leveraging data from the Medical Information Mart for Intensive Care IV database, we collected comprehensive raw data pertaining to elderly patients diagnosed with ischemic stroke. Through meticulous screening of clinical variables associated with 28-day mortality, we successfully established a robust nomogram. To assess the performance and clinical utility of our nomogram, various statistical analyses were conducted, including the concordance index, integrated discrimination improvement (IDI), net reclassification index (NRI), calibration curves and decision curve analysis (DCA). Our study comprised a total of 1259 individuals, who were further divided into training (n = 894) and validation (n = 365) cohorts. By identifying several common clinical features, we developed a nomogram that exhibited a concordance index of 0.809 in the training dataset. Notably, our findings demonstrated positive improvements in predictive performance through the IDI and NRI analyses in both cohorts. Furthermore, calibration curves indicated favorable agreement between the predicted and actual incidence of mortality (P > 0.05). DCA curves highlighted the substantial net clinical benefit of our nomogram compared to existing scoring systems used in routine clinical practice. In conclusion, our study successfully constructed and validated a prognostic nomogram, which enables accurate short-term mortality prediction in elderly individuals with ischemic stroke.

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Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history

Cited by 3 publications

References 22 publications

Malignant tumor increases the risk of all causes in-hospital mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database

Malignant tumor increases the risk of all causes in-hospital mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database

Recent cancer history and its impact on cardiovascular outcomes and mortality after an incident ischemic stroke

Development and verification of a nomogram for predicting short-term mortality in elderly ischemic stroke populations

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