Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Dong, Xinli; Zhou, Mi; Li, Yehong; Li, Yuxin; Ji, Hui; Hu, Qinghua

doi:10.3389/fphar.2021.783641

Cited by 14 publications

(7 citation statements)

References 75 publications

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“…Polysaccharide is a natural biological macromolecule with a wide range of biological activities such as immunomodulatory, antitumor, antiviral, antioxidant, hypoglycemic, and hypolipidemic. Polysaccharides could regulate glucose and lipid metabolism by protecting islet cells, improving insulin sensitivity, regulating intestinal flora, increasing antioxidant capacity, and regulating the activity of key enzymes for glucose and lipid metabolism [38,39] .…”

Section: Polysaccharidesmentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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Hyperlipidemia is a kind of lipid metabolism disease, whose pathogenesis is complex and diverse, mainly related to abnormal glucose and lipid metabolism, as well as insulin resistance and other characteristics. Because of their low toxic and side effects along with clear medicinal effects, the food and medicinal homological resources are widely used in the regulation of blood lipids in recent years. The State Administration for Market Regulation website and various databases have been searched for the use of food and medicinal homological materials in functional food products, the categories and frequency in food and medicinal homological resources, the lipid-lowering active ingredients and their mechanisms. The results showed that 53 kinds of food and medicinal homological resources were used to regulate blood lipids, of which Crataegus pinnatifida Bge., Cassia obtusifolia L., Nelumbo nucifera Gaertn., Morus alba L. and Pueraria lobata (Willd.) Ohwi were used most frequently. The main active ingredients are triterpenes and their glycosides, flavonoids, alkaloids and polysaccharides, etc., they regulated blood lipid levels and cholesterol metabolism by activating AMPK and PPARγ.

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Section: Polysaccharidesmentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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“…In recent years, plant polysaccharides as a class of natural products have been the subject of intensive investigation. Numerous studies have demonstrated that plant polysaccharides could improve cardiovascular diseases by anti-oxidative stress, restoring the metabolism of biological macromolecules, regulating apoptosis, and inhibiting inflammatory signal pathways (Dong et al, 2021;Zhou et al, 2021). In particular, polysaccharides have a good role in the prevention and treatment of DCM.…”

Section: Pp Alleviated Myocardial Fibrosis In Model Ratsmentioning

confidence: 99%

Polygonatum polysaccharide attenuates inflammation through inhibiting NLRP3 inflammasome in diabetic cardiomyopathy rats

et al. 2023

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Polygonatum polysaccharide (PP) has good myocardial protection. This study aims to find whether PP can relieve inflammation and play a protective role in diabetic cardiomyopathy (DCM). Intraperitoneal injection of streptozotocin was used to induce DCM in rats, which were then separated into four groups: model group, PP-200 group (200 mg/kg PP), PP-400 group (400 mg/kg PP), and Met group (120 mg/kg metformin). Both control (NC) and model groups of rats were administered normal saline. According to the kit instructions mentioned on the kit, the levels of blood glucose, glycosylated hemoglobin, insulin (INS), and myocardial enzymes (creatinine kinase, B-type natriuretic peptide, and cardiac troponin I) were measured after 8 weeks. Cardiac function was detected by echocardiography. Hematoxylin and eosin (HE) and Masson staining were used to observe pathological changes. Myocardial RNA and protein levels of NLR family pyrin domain containing 3 (NLRP3), caspase-1, and Gasdermin D (GSDMD) were quantified through reverse transcription-polymerase chain reaction and Western blotting analysis. The in vivo findings showed that PP could reduce blood glucose, glycosylated hemoglobin, and INS levels, enhance heart functioning, restore histological alterations and myocardial enzymes, and relieve myocardial fibrosis. Furthermore, PP suppressed the expressions of NLRP3, caspase-1, and GSDMD. PP could reduce inflammation in DCM rats by suppressing NLRP3 inflammasome.

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“…Polysaccharides are widely distributed as natural ingredients in vegetables and fruits. Several studies have shown that the polysaccharides improve cardiovascular diseases through various mechanisms, such as anti-oxidative stress, regulating metabolism, anti-inflammatory, anti-cancer, and immunity-booster properties ( 262 ).…”

Section: Cardioprotective Phytochemicals Attenuating Myocardial I/r I...mentioning

confidence: 99%

Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

Chen

Cheng

et al. 2022

Front. Cardiovasc. Med.

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Percutaneous coronary intervention (PCI) is one of the most effective reperfusion strategies for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury, causing one of the causes of most cardiomyocyte injuries and deaths. The pathological processes of myocardial I/R injury include apoptosis, autophagy, and irreversible cell death caused by calcium overload, oxidative stress, and inflammation. Eventually, myocardial I/R injury causes a spike of further cardiomyocyte injury that contributes to final infarct size (IS) and bound with hospitalization of heart failure as well as all-cause mortality within the following 12 months. Therefore, the addition of adjuvant intervention to improve myocardial salvage and cardiac function calls for further investigation. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in Chinese herbal medicine. Great effort has been put into phytochemicals because they are often in line with the expectations to improve myocardial I/R injury without compromising the clinical efficacy or to even produce synergy. We summarized the previous efforts, briefly outlined the mechanism of myocardial I/R injury, and focused on exploring the cardioprotective effects and potential mechanisms of all phytochemical types that have been investigated under myocardial I/R injury. Phytochemicals deserve to be utilized as promising therapeutic candidates for further development and research on combating myocardial I/R injury. Nevertheless, more studies are needed to provide a better understanding of the mechanism of myocardial I/R injury treatment using phytochemicals and possible side effects associated with this approach.

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Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Cited by 14 publications

References 75 publications

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Polygonatum polysaccharide attenuates inflammation through inhibiting NLRP3 inflammasome in diabetic cardiomyopathy rats

Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

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