Cardiovascular remodeling in active and controlled acromegaly: association with sleep-disordered breathing

Filchenko, Irina; Korostovtseva, Lyudmila; Bochkarev, Mikhail; Tsoy, U. A.; Sviryaev, Yurii

doi:10.1007/s11325-023-02838-9

Cited by 2 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[18] OSAHS is also a common comorbidity of acromegaly and has long-term implications for cardiovascular remodeling. [3,19,20] Interestingly, we only found a higher rate of OSAHS related with obesity in pediatric-onset group, indicating that more importance should be attached to OSAHS screening on younger-onset obese GHPA patients. HOMA-IR and HOMA-β are good indexes of insulin resistance and β-cell function respectively.…”

Section: Discussionmentioning

confidence: 64%

See 1 more Smart Citation

Distinct clinical characteristics and prognosis of pediatric-onset GHPA patients compared with adult-onset patients

Zheng,

Yang,

Xiao

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose To explore the clinical characteristics, treatment, and prognosis of growth hormone-secreting pituitary adenoma (GHPA) patients with pediatric-onset, so as to facilitate the clinical management. Methods A retrospective cohort study was carried out between 102 pediatric-onset GHPA patients admitted to our hospital from January 2013 to June 2022 and 204 adult-onset GHPA patients who were randomly matched. Results GHPA with pediatric-onset was predominantly male, associated with higher proportion of genetic syndromes, longer course, and delay on diagnosis. Clinical symptoms of visual field defects and menstrual abnormality were more common. The pediatric-onset group presented with higher growth hormone (GH) nadir during oral glucose tolerance test (OGTT), higher rates of hyperprolactinemia, larger maximum diameter of adenoma, higher rates of optic chiasm compression, suprasellar invasion, and pituitary apoplexy. Hypertension, diabetes, and obstructive sleep apnea-hypopnea syndrome (OSAHS) were more common in the adult-onset group. Echocardiography results were similar between the two groups. The pediatric-onset group owned significantly higher treatment scores and proportions of multimodal therapy modality, more surgical complications, and a higher proportion of ki67 ≥ 3%. There was no significant difference in the final cure rate, but male patients with adult-onset had a worse prognosis. The recurrence rate was also similar between two groups. Hypopituitarism was more prevalent in the pediatric-onset group, while the adult-onset group had a higher rate of combining other tumors. Conclusion The clinical characteristics of pediatric-onset GHPA patients were different from adult-onset patients. Multimodal therapy modalities could help to achieve a cure rate similar to that of adult-onset patients.

show abstract

Section: Discussionmentioning

confidence: 64%

“…19.3% vs. 8.2%, p = 0.042). The proportion of patients who received at least 2 surgeries (26.5% vs. 19.3%) or radiotherapy (23.5% vs. 16.3%) were similar between two groups.…”

mentioning

confidence: 91%