Cardiovascular Response to Adrenergic Stimulation during Treatment with Tertatolol. A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients.

Fasano, Maria Luisa; Gaeta, Iole; Simone, Giuseppina De; Iannuzzi, R.; Ferrara, Liberato

doi:10.1536/ihj.32.435

Jpn Heart J

1991

DOI: 10.1536/ihj.32.435

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Cardiovascular Response to Adrenergic Stimulation during Treatment with Tertatolol. A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients.

Maria Luisa Fasano¹,

Iole Gaeta²,

Giuseppina De Simone³

et al.

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2014

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Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension

Wong

Wright

2014

Cochrane Database of Systematic Reviews

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In people with mild-to-moderate hypertension, nonselective beta-blockers lowered peak BP by a mean of -10/-7 mmHg (systolic/diastolic) and reduced heart rate by 12 beats per minute. Propranolol and penbutolol were the two drugs that contributed to most of the data for nonselective beta-blockers. This estimate is likely exaggerated due to the presence of extreme outliers and other sources of bias. If we removed the extreme outliers from the analysis, the estimate for non-selective beta-blockers was lower (-8/-5 mmHg (systolic/diastolic)). Nonselective beta-blockers did not show a convincing graded dose-response in the recommended dose range for systolic BP and diastolic BP, while higher dose nonselective beta-blockers provided greater reduction of heart rate. Using higher dose nonselective beta-blockers might cause more side effects, such as bradycardia, without producing an additional BP lowering effect. The effect of nonselective beta-blockers on pulse pressure was likely small, at about 2 mmHg.

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Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension

Wong

Wright

2014

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

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Cardiovascular Response to Adrenergic Stimulation during Treatment with Tertatolol. A New Non-Cardioselective Beta-Blocking Agent in Primary Hypertensive Patients.

Cited by 1 publication

References 16 publications

Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension

Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension

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