1987
DOI: 10.1111/j.2042-7158.1987.tb06974.x
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Cardiovascular responses in rats with chronic renal failure

Abstract: Cardiovascular responses were determined in rats with chronic renal failure (CRF) produced by five sixths nephrectomy and in sham-operated rats. The conscious systolic blood pressure of rats with CRF was significantly higher than the pressure in controls although, after anaesthesia, there were no significant differences in the mean arterial pressure between the two groups of rats. The pressor responses to noradrenaline in rats with CRF were not significantly different from those recorded in sham-operated contr… Show more

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Cited by 4 publications
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“…The basal tension was not signifi cantly different in both groups either: responsiveness of the heart to catecholamines could not be demonstrated by determining the concentration-effect relationship in organ bath experiments. This is in accordance with clinical investigations in which systolic func tion in uremic patients without ischemic heart disease was normal and the pharmacody namic response to ( ± ) dobutamine was preserved [7], Similar observations have also been made in animal experiments [15] by other research workers. Thus, the biochemi cal alteration appears to have no physiologi cal relevance with respect to the positive ino tropic action of catecholamines.…”
Section: Myocardial C a M P Levels And Inotropic Responsiveness In Tesupporting
confidence: 78%
“…The basal tension was not signifi cantly different in both groups either: responsiveness of the heart to catecholamines could not be demonstrated by determining the concentration-effect relationship in organ bath experiments. This is in accordance with clinical investigations in which systolic func tion in uremic patients without ischemic heart disease was normal and the pharmacody namic response to ( ± ) dobutamine was preserved [7], Similar observations have also been made in animal experiments [15] by other research workers. Thus, the biochemi cal alteration appears to have no physiologi cal relevance with respect to the positive ino tropic action of catecholamines.…”
Section: Myocardial C a M P Levels And Inotropic Responsiveness In Tesupporting
confidence: 78%