Cardiovascular Responses to Diazepam and Midazolam Maleate in the Dog

Jones, David J.; Stehling, Linda C.; Zauder, Howard L.

doi:10.1097/00000542-197911000-00012

Cited by 142 publications

(47 citation statements)

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“…At higher concentrations, this agent may block the sinoatrial node function and His-Purkinje system conduction [24]. Administered at a dose similar HR -heart rate; A-A -interval between the onset of the P-wave; V-V -interval between the onset of the R-wave; PA -interval between the onset of the P-wave and the intrinsic deflection of the atrial electrogram on the bundle record- to that used in our study, midazolam exerts only a slight effect on the conduction parameters [25]. Only few studies with complete EPS protocols have been published thus far, and, owing to the different models of anesthesia used in these experiments, their results are hardly comparable.…”

Section: Discussionmentioning

confidence: 65%

Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study

Noszczyk-Nowak

Cepiel

Janiszewski³

et al. 2016

Adv Clin Exp Med

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size, diameters of coronary arteries, susceptibility to coronary atherosclerosis, coronary stent-related restenosis, infarct development and post-infarction remodeling in these two species, and owing Swine are a well-recognized animal model for human cardiovascular diseases [1][2][3][4]. Porcine models have been increasingly used in human cardiovascular research due to similarities in the heart Agnieszka Noszczyk-Nowak 1, A-D, F , Alicja Cepiel 1, B, C, F , Adrian Janiszewski 2, B, E, F , Robert Pasławski 3, B, F , Jacek Gajek 4, A, E, F , Urszula Pasławska 1 A -research concept and design; B -collection and/or assembly of data; C -data analysis and interpretation; D -writing the article; E -critical revision of the article; F -final approval of article AbstractBackground. Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. Objectives. The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine. Material and Methods. The study included 36 healthy domestic swine (24-40 kg body weight). EPS was performed under a general anesthesia with midazolam, propofol and isoflurane. The reference values for intracardiac electrical activity and conduction parameters were calculated as arithmetic means ± 2 standard deviations. Results. The reference values were determined for AH, HV and PA intervals, interatrial conduction time at its own and imposed rhythm, sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), anterograde and retrograde Wenckebach points, atrial, atrioventricular node and ventricular refractory periods. No significant correlations were found between body weight and heart rate of the examined pigs and their electrophysiological parameters. Conclusions. The hereby presented reference values can be helpful in comparing the results of various studies, as well as in more accurately estimating the values of electrophysiological parameters that can be expected in a given experiment (Adv Clin Exp Med 2016, 25, 6, 1249-1254).

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Section: Discussionmentioning

confidence: 65%

Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study

Noszczyk-Nowak

Cepiel

Janiszewski³

et al. 2016

Adv Clin Exp Med

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“…Este fato pode ser explicado, pois segundo JONES et al (1979), os benzodiazepínicos ocasionam ligeira queda da pressão arterial, decorrente da redução da resistência vascular periférica.…”

Section: Resultsunclassified

Parametria da associação do midazolam ou diazepam em cães pré-tratados pela atropina e tratados pela dexmedetomidina e quetamina

et al. 2006

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“…In raccoon dogs anaesthetised with the DMBA combination, the pulse rate and blood pressure were changed after drug administration. This is likely due to the fact that midazolam decreases systemic vascular resistance (Jones et al 1979;Samuelson et al 1981) which is often accompanied by compensatory decreases in PR. Kunisawa et al (2009) reported that administration of dexmedetomidine in combination with other anaesthetics during anaesthetic induction may prevent a decrease in blood pressure.…”

Section: Murthy and Singh 2009)mentioning

confidence: 99%

Effects of the dexmedetomidine, midazolam, butorphanol, and atropine combination on plasma oxidative status and cardiorespiratory parameters in raccoon dogs (Nyctereutes procyonoides)

Feng¹,

Hu²,

Zhang³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:Oxidative stress in the body occurs when the production of free radicals overwhelms the antioxidant defence systems. This study aimed to investigate the effects of a combination of dexmedetomidine, midazolam, butorphanol, and atropine (DMBA) as an anaesthetic on plasma oxidative status in twelve raccoon dogs. Baseline measures were recorded prior to anaesthesia, and then the animals were anaesthetised with the combination of dexmedetomidine (25 µg/kg), midazolam (0.45 mg/kg), butorphanol (0.25 mg/kg), and atropine (0.035 mg/kg). Temperature, respiratory rate, haemoglobin saturation by oxygen, pulse rate, systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were continually monitored. Blood pressure was significantly decreased at 30 to 60 min (P < 0.05). Pulse rate ranged from 96 to 123 bpm, without episodes of severe bradycardia or tachycardia. Blood samples were collected from saphenous venipuncture at 0, 0.5, 1, and 24 h before, during, and after anaesthesia. Plasma superoxide dismutase, glutathione peroxidase, and catalase activity, and malondialdehyde concentrations were measured by colorimetry, and plasma vitamin E level was determined by high-performance liquid chromatography. Superoxide dismutase and glutathione peroxidase activities increased significantly (P < 0.05) at 0.5 h, and then gradually decreased to baseline values after 1 h. Catalase activity increased significantly (P < 0.05) at 0.5 h, 1 h, and then gradually decreased to baseline values after 24 h. There was no significant change in vitamin E level (P < 0.05).The concentration of malondialdehyde decreased significantly at 0.5, 1, and 24 h after injection (P < 0.05). The results show that the administered dose of dexmedetomidine, midazolam, butorphanol, and atropine has antioxidant effects in raccoon dogs. Our study is the first to demonstrate that dexmedetomidine, midazolam, butorphanol, and atropine exert antioxidant effects, which may be exploited to alleviate the stress of examination and research at veterinary clinics.

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Cardiovascular Responses to Diazepam and Midazolam Maleate in the Dog

Cited by 142 publications

References 0 publications

Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study

Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study

Parametria da associação do midazolam ou diazepam em cães pré-tratados pela atropina e tratados pela dexmedetomidina e quetamina

Effects of the dexmedetomidine, midazolam, butorphanol, and atropine combination on plasma oxidative status and cardiorespiratory parameters in raccoon dogs (Nyctereutes procyonoides)

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