Cardiovascular Risk and Statin Therapy Considerations in Women

Gheorghe, Gina; Tóth, Peter P.; Bungău, Simona; Behl, Tapan; Ilie, Mădălina; Stoian, Anca Pantea; Bratu, Ovidiu Gabriel; Bacalbaşa, Nicolae; Rus, Marius; Diaconu, Camelia Cristina

doi:10.3390/diagnostics10070483

Cited by 68 publications

(53 citation statements)

References 121 publications

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“…We did not find correlation between MPV and mortality or adverse outcome on short term in the present study. MPV could be influenced by previous medication consisting of statin therapy as described in other studies [59][60][61] or EDTA can increase platelet size by causing platelet swelling.…”

Section: Discussionmentioning

confidence: 95%

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

et al. 2021

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The values of hematological and coagulation biomarkers were evaluated as predictors of in hospital mortality and complications, in patients with acute coronary syndromes (ACS). This retrospective observational study enrolled 936 ACS subjects admitted to the Clinical Emergency Hospital of Oradea, Romania, between January–December 2019. Hematological and coagulation parameters were obtained at admission. During hospitalization, the following adverse events were recorded: death, ventricular rhythm disturbances, atrial fibrillation, heart failure, re-infarction, and stroke. Accuracy of hematological and coagulation parameters as predictors of adverse outcome were also evaluated. The diagnosis was unstable angina in 442 patients (47.22%), non-ST-elevation myocardial infarction (NSTEMI) in 113 patients (12.1%) and ST-elevation myocardial infarction (STEMI) in 381 patients (40.70%); 87 patients (9.29%) died during hospitalization and 193 (20.7%) developed complications. Predictors for in hospital mortality were as follows: red cell distribution width (RDW) (AUC 0.691, p < 0.0001), white blood cells (WBC) (AUC 0.684, p < 0.0001), neutrophils (NEU) (AUC 0.684, p < 0.0001), and prothrombin time (PT) (AUC 0.765, p < 0.0001). WBC (AUC 0.659, p < 0.0001), NEU (AUC 0.664, p < 0.0001), RDW (AUC 0.669, p < 0.0001), and PT (AUC 0.669, 95% CI 0.622–0.714, p < 0.0001) also had accuracy for complications prediction. RDW had a good ability to predict heart failure in NSTEMI patients (AUC 0.832, p < 0.0001). An acceptable ability to predict ventricular rhythm disturbances occurrence had WBC (AUC 0.758, p < 0.0001) and NEU (AUC 0.772, p < 0.0001). Hematological and coagulation parameters can help in risk stratification of ACS patients. RDW, WBC, NEU, and PT were able to predict mortality and in-hospital complications in ACS patients. RDW has a good accuracy in predicting complications and heart failure in NSTEMI patients. WBC and NEU are good predictors for ventricular rhythm disturbances.

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Section: Discussionmentioning

confidence: 95%

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

et al. 2021

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“…In the general population, dyslipidemia and obesity have been identified to be predisposing factors for diabetes mellitus and increase CV risk in those patients [33]. Moreover, in women, the need for accurate diagnosis of obesity has been elucidated since it considerably increases the risk of CVD, and treatment of dyslipidemia may be challenging [34]. It is known that CVD pathogenesis differs concerning sex and that hypertrophic changes in the left ventricle in men are strongly associated with CV mortality [35].…”

Section: Discussionmentioning

confidence: 99%

Waist Circumference as a Preventive Tool of Atherogenic Dyslipidemia and Obesity-Associated Cardiovascular Risk in Young Adults Males: A Cross-Sectional Pilot Study

et al. 2020

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Although the correlation coefficient between body mass index (BMI) and poor lipid profile has been reported, representing a cardiovascular risk, the need to find new early detection markers is real. Waist circumference and markers of atherogenic dyslipidemia are not usually measured in medical review appointments. The present study aimed to investigate the relationship between central adiposity and cardiovascular risk. This was a cross-sectional pilot study of 57 young males (age: 35.9 ± 10.85, BMI: 32.4 ± 6.08) recruited from community settings and allocated to non-obese or obese attending to their waist circumference. Total cholesterol (TC), high-density lipoproteins (HDL-C), and low-density lipoproteins (LDL-C) cholesterol and triglycerides (TG) were measured from plasma samples. Patients with at least 100 cm of waist circumference had significantly increased TC, LDL-C, non-HDL-C, and triglycerides and lower levels of HDL-C. The three atherogenic ratios TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C were all optimal in non-obese patients. LDL-C/HDL-C and TG/HDL-C were significantly higher and over the limit when assessing for atherogenic dyslipidemia. The number of patients at risk for cardiovascular events increases 2.5 folds in obese compared to non-obese. Measurement of waist circumference could be adopted as a simpler valid alternative to BMI for health promotion, to alert those at risk of atherogenic dyslipidemia.

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“…The role of the increased content of intracellular calcium entering the cells under the action of prostaglandins and leading to cell destruction activated by neutral proteases is not excluded 17 . Various additional risk factors may contribute to the development of RM upon SS (statins, alcohol consumption, etc) 18 . In our patient, one additional factor may be considered the presence of diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

"Total laryngectomy with voice prosthesis – „gold standard“ treatment for patients with advanced laryngeal cancer"

Vasileva¹,

Slavchev²,

Kostov³

et al. 2020

Arch Balk Med Union

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Rhabdomyolyse accompagnant la septicémie staphylococcique Introduction. La rhabdomyolyse est un syndrome clinique et de laboratoire résultant de lésions musculaires squelettiques avec libération d'un grand nombre de substances intracellulaires de myocytes dans la circulation systémique et endo-toxémie. L'entrée des produits de destruction musculaire dans la circulation systémique entraîne le développement de manifestations systémiques, de troubles graves de l'homéostasie, du syndrome de défaillance multiviscérale, y compris une insuffisance rénale aiguë, menaçant souvent la vie du patient. Rapport de cas. Un cas rare de rhabdomyolyse chez un patient souffrant de septicémie staphylococcique et de développement d'une défaillance d'organes multiples est décrit. La présence de la rhabdomyolyse est confirmée par les résultats d'études pathologiques et anatomiques. Les causes possibles de la rhabdomyolyse dans la septicémie staphylococcique sont discutées ici. Conclusions. Seuls quelques cas de rhabdomyolyse à fond de septicémie staphylococcique ont été trouvés ABSTRACT Introduction. Rhabdomyolysis (RM) is a clinical and laboratory syndrome resulting from skeletal muscle damage, with the release of a big number of intracellular substances of myocytes into the systemic circulation and endotoxemia. The entry of the muscle destruction products into the systemic circulation leads to the development of systemic manifestations, serious disorders in homeostasis, multiple organ failure syndrome, including acute renal failure, often threatening the patient's life. Case report. A rare case of RM in a patient with staphylococcal sepsis (SS) and development of multiple organ failure is described. The diagnosis of RM was confirmed by the results of pathological and anatomical studies. Possible causes of RM in staphylococcal sepsis are discussed here. Conclusions. Only a few cases of RM upon SS were found in the literature. The development of RM in combination with the systemic inflammatory reaction syndrome in SS exacerbates the course of the disease and worsens its prognosis. Therefore, the timely diagnosis of RM and appropriate treatment are extremely important. The mechanism of RM development upon

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Cardiovascular Risk and Statin Therapy Considerations in Women

Cited by 68 publications

References 121 publications

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

Waist Circumference as a Preventive Tool of Atherogenic Dyslipidemia and Obesity-Associated Cardiovascular Risk in Young Adults Males: A Cross-Sectional Pilot Study

"Total laryngectomy with voice prosthesis – „gold standard“ treatment for patients with advanced laryngeal cancer"

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