Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance

Rovio, Suvi; Pahkala, Katja; Nevalainen, Jaakko; Juonala, Markus; Salo, Pia; Kähönen, Mika; Hutri‐Kähönen, Nina; Lehtimäki, Terho; Jokinen, Eero; Laitinen, Tomi; Taittonen, Leena; Tossavainen, Päivi; Viikari, Jorma; Rinne, Juha O.; Raitakari, Olli T.

doi:10.1016/j.jacc.2017.02.060

Cited by 126 publications

(92 citation statements)

References 42 publications

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“…The representativeness of the study population participating in the study was examined by comparing the baseline differences between participants and nonparticipants (Supplementary Table 1). Participants were a little younger and more often female than nonparticipants, which is common among longterm observational studies (25). Similar race and studied CVRFs were observed.…”

Section: Resultsmentioning

confidence: 52%

Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study

Fernandez

Barshop

et al. 2019

Diabetes Care

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Childhood and young adulthood may represent time periods in which cardiovascular risk factors (CVRFs) and their cumulative exposure lay the foundation for future risk of chronic diseases. We examined the longitudinal burden of CVRFs since childhood in men and women in whom diabetes did and did not develop at follow-up. RESEARCH DESIGN AND METHODS We included 1,530 participants (mean [SD] follow-up time 33.1 [8.2] years), who participated in the Bogalusa Heart Study and had been examined at least four times starting in childhood (mean age [SD] at first examination 9.4 [3.1] years). The area under the growth curve was used as a measure of cumulative exposure to CVRFs since childhood. RESULTS In childhood, boys and girls in whom diabetes did and did not develop at follow-up had similar CVRFs. Yet, over time, women during the transition from normoglycemia to diabetes experienced greater adverse changes in total cholesterol (TC), LDL cholesterol, and fasting plasma glucose (FPG) (noted as early as 23.5 years old and persisting across adulthood up to the age of the diagnosis of diabetes); a higher burden of exposure to BMI, TC, LDL cholesterol, and FPG from childhood to midlife; and a greater change in rates of BMI, TC, LDL cholesterol, and FPG since childhood than men during the same transition (interaction P values <0.05). CONCLUSIONS The greater exposure of women to and burden of CVRFs associated with diagnosis of diabetes may help to explain the stronger impact of diabetes as a major risk factor for cardiovascular events in women compared with men. The burden of cardiovascular disease (CVD) related to diabetes is a major public health challenge (1). There is a well-recognized CVD risk disparity by sex among individuals with diabetes (2-5). Women with diabetes are at markedly increased risk of CVD events compared with women without diabetes, whereas men with diabetes

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Section: Resultsmentioning

confidence: 52%

Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study

Fernandez

Barshop

et al. 2019

Diabetes Care

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“…Accumulation of CVD risk factors in childhood influences both arterial stiffness/thickness and cognitive function in young adulthood [10–12]. Our findings demonstrate that associations between large artery stiffness and cerebral hemodynamic pulsatility manifest at a young age.…”

Section: Discussionmentioning

confidence: 67%

Carotid artery stiffness and cerebral pulsatility in children

Lefferts¹,

DeBlois²,

Gump³

et al. 2018

ARTRES

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“…Epidemiologic studies have reported the several risk factors for this category of diseases. In the pathophysiology of atherosclerosis, impaired plasma levels of lipoproteins including high cholesterol, high LDL cholesterol, high serum TG, low HDL cholesterol, and lipid metabolism disorders are more than other factors affecting atherosclerosis [3]. Also, increased inflammation and oxidative stress are considered to be major risk factors for atherosclerosis and cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Curcumin nanomicelle versus curcumin improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A Randomized Clinical Trial

Helli

Gerami

Kavianpour

et al. 2019

Preprint

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Background: Curcumin exhibited antioxidant and anti-inflammatory effects. The aim of this study, assess and compare curcumin and nano-curcumin effects on lipid profile, oxidative stress index and inflammatory factors of heart patients. Methods: This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted on 90 patients undergoing coronary elective angioplasty. Patients were randomly divided into 3 groups. The first group received a 500 mg capsule of curcumin daily. The second group received an 80 mg capsule of nano-curcumin daily. The placebo group also received capsules similar to curcumin for 8 weeks. Lipid profile, stress oxidative factors and inflammatory markers measured in baseline and end of the investigation.Results: At the end of study, statistically significant changes was seen in the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in the intervention groups to the control group (p<0.05). These changes in the nano-curcumin group were greater than the curcumin group.Curcumin and nano-curcumin supplementation also caused a statistically significant improvement in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) in comparison to the placebo (p<0.05).Conclusion: Complementary therapy of cardiovascular patients with curcumin and nano-curcumin supplements, could improve lipid profile, stress oxidative index and, inflammatory factors. The effects of curcumin on nano formula may be better for cardiac patients due to high bioavailability. However, further investigation is suggested in this regard.

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Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance

Abstract: Cumulative burden of cardiovascular risk factors from childhood/adolescence associate with worse midlife cognitive performance independent of adulthood exposure.

Cited by 126 publications

References 42 publications

Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study

Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study

Carotid artery stiffness and cerebral pulsatility in children

Curcumin nanomicelle versus curcumin improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A Randomized Clinical Trial

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