Cardiovascular risk factors in centenarians

Galioto, Antonio; Lj, Dominguez; Pineo, Antonella; Ferlisi, Anna; Putignano, Ernesto; Belvedere, Mario; Costanza, Giuseppe; Barbagallo, Mario

doi:10.1016/j.exger.2007.06.009

Cited by 63 publications

(53 citation statements)

References 57 publications

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“…attributed to both genetic and lifestyle factors as well as pharmacotherapy 263 and survivor bias. Hypertension precedes MI and angina in a large majority of the elderly with these conditions.…”

Section: Aronow Et Al Hypertension In the Elderlymentioning

confidence: 99%

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

et al. 2011

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Section: Aronow Et Al Hypertension In the Elderlymentioning

confidence: 99%

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

et al. 2011

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“…These values are lower than those reported in other national survey for the same age group (159 Ϯ 37 mg/dl) and similar to the Cardiovascular Health Study (Ettinger et al, 1992 population due to the premature death of hypercholesterolemic individuals, since subjects with dyslipidemia rarely reach extreme old age (Galloto et al, 2008). However the importance of hypercholesterolemia as a risk factor for cardiovascular disease over 70 years' old people is controversial.…”

Section: Age Sex and Serum Lipidscontrasting

confidence: 40%

Lipid profile and dietary habits in an elderly rural population in the southern Spain: the <i>Sierra de Huelva</i> study

Martı́n¹,

Escudero-Gilete²,

Vicario³

2009

Grasas y Aceites

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We have assessed serum lipids, systolic (SBP) and diastolic (DBP) blood pressure in a healthy, free living population over 70 years old residing for more than 20 years in a rural area located in the southern Spain, the Sierra de Huelva. 401 elderly, 229 women (F) and 179 men (M) mean age 79.36 ± 6.9 were included in this cross-sectional observational study. Dietary habits were assessed by means of a Modification of the Mediterranean Diet Score (MDDS), which comprised 11 components. A total score ranging from 0-44 was calculated. Mean concentration for lipids were: Total cholesterol (TC) 193.8 ± 23.1, M 195.2 ± 25.7 and F 192.7 ± 20.8 (p = 0.29); HDLc 60.3 ± 7.6 mg/dl, M 60.0 ± 8.0 and F 60.5 ± 7.2 (p = 0.49); TC/HDLc 3.3 ± 1.1 mg/dl, M 3.4 ± 1.2 and F 3.3 ± 1.1 mg/dl (p < 0.35); LDLc 127.3 30.1 mg/dl, M 129.0 ± 32.9 F 126.0 ± 27.8 mg/dl (p = 0.33); TG 137.7 ± 18.3, M 138.8 ± 19.4 and F 136 ± 17.4 (p = 0.30). Global prevalence of hypercholesterolemia (TC ≥200 mg/dl) was 8.7%, F 7.9% and M 9.9%; 10.7% had LDLc≥160 mg/dl. In this study, age was negatively correlated (p < 0.05) with TC, LDLc, TG and SBP and positively with HDLc. Pig meat consumption was negatively correlated with CT and LDLc, and positively with HDLc. According to MMDS data, 60.6 ± 6.9% of adherence to the Mediterranean diet was obtained. The MMDS was positively associated with age and negatively with TG (p < 0.05). Further studies are needed to establish the influence of local Iberian pig meat products consumption and life style on the lower incidence of risk factors for CVD and the higher life expectancy of the studied population.

Hemos evaluado los lípidos séricos, la presión sistólica (SBP) y diastólica (DBP) en un grupo de ancianos no institucionalizados de más de 70 años que residen en una zona rural localizada en el sur de España, la Sierra de Huelva. 401 ancianos, 229 mujeres (F) and 179 hombres (M) con una edad media de 79,36 ± 6,9 años, se incluyeron en este estudio observacional transversal. Los hábitos alimentarios fueron evaluados mediante una modificación del Mediterranean Diet Score MMDS) que incluyó a 11 grupos de alimentos. Se obtuvo una puntuación total que oscilaba entre 0-44. La concentración media de lípidos fue: colesterol total (TC) 193,8 ± 23,1, M 195,2 ± 25,7 y F 192,7 ± 20,8 (p = 0,29); HDLc 60,3 ± 7,6 mg/dl, M 58,0 ± 8,0 y F 60,5 ± 7,2 (p = 0,49); TC/HDLc 3,3 ± 1,1 mg/dl, M 3,4 ± 1,2 and F 3,3 ± 1,1 mg/dl (p < 0,35); LDLc 127,3 ± 30,1 mg/dl, M 129,0 ± 32.9 F 127,3 ± 30,1 mg/dl (p < 0,33); TG 137,7 ± 18,8, M 138,8 ± 19,4 y F 136,0 ± 17,4 (p < 0,30). La prevalencia total de hipercolesterolemia (TC 200 mg/dl) fue de 8,7%, F 7,9% y M 9,9%; 10,7% de la población presentó niveles de LDLc≥160 mg/dl. La edad se correlacionó negativamente (p < 0,05) con TC, LDLc, TG y SBP y positivamente con el HDLc. Según los datos de MMDS la adherencia a la Dieta Mediterranea fue del 60.6 ± 6.9%. El consumo de carne de cerdo se correlacionó negativamente con CT y LDLc, y positivamente con HDLc. El MMDS se relacionó positivamente con...

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“…Mean values of systolic and diastolic blood pressure were 126.9 8 17.1 and 70. 8 Entirely normal ECG recordings were found in 7 centenarians (16.6%). The most frequently observed abnormalities included: left-axis deviation and left anterior hemiblock in 16 centenarians (38.09%), left ventricular hypertrophy and nonspecific ST-T wave abnormalities in 13 subjects (30.95%).…”

Section: Resultsmentioning

confidence: 95%

Electrocardiographic Changes in Centenarians: A Study on 42 Subjects and Comparison with the Literature

et al. 2011

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Background: Aging is associated with extensive and pervasive changes in cardiovascular structure and function, which may result in electrocardiographic alterations. The typical modifications seen in an electrocardiogram (ECG) in elders are: prolonged PR and QT intervals, QRS left-axis deviation and microvolt T wave. Several studies have included elderly people, but not long-living elderly and centenarians in particular who represent an increasing part of the population. Objective: The aim of this study was to investigate the electrocardiographic findings in a population of centenarians and to compare the results with the few studies present in the literature. Methods: We analyzed 42 healthy centenarians (12 males, 30 females; average age 101.43 ± 1.80 years) living in Messina, a municipality of Eastern Sicily, in Italy. They were clinically and functionally evaluated. All ECGs were analyzed by a single observer blind to clinical data. We assessed survival by phone recall. Results: PR interval mean duration was 190 ± 3.3 ms, QRS 90 ± 1.4 ms, QTc interval mean duration was 370 ± 3.5 ms. Entirely normal ECG recordings were found in 7 centenarians (16.6%). The most frequently observed abnormalities included left-axis deviation and left anterior hemiblock in 16 centenarians (38.09%), left ventricular hypertrophy and aspecific ST-T wave abnormalities in 13 subjects (30.95%). We found no statistically significant differences between men and women. The mean age at death was 102.44 ± 2.45, and we did not find significant differences in age at death in long-living elderly in relation to different electrocardiographic findings. Comparing our results with two previous studies in the literature, the first conducted in Switzerland [Cornu: Rev Med Suisse Rom 1979;99:107–113] and the second in Nebraska [Lakkireddy et al.: Am J Cardiol 2003;92:1249–1251], we found a higher frequency of left ventricular hypertrophy that was compatible with the prevalence of hypertension in our centenarians (33.3%). Moreover, we did not find left bundle branch block, and the frequency of premature beats was remarkably less than that observed in the Swiss and US studies. Conclusions: Considering the increasing rate of centenarians, we believe that the results of the present study on electrocardiographic changes in centenarians may also be useful in clinical practice.

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Cardiovascular risk factors in centenarians

Cited by 63 publications

References 57 publications

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

Lipid profile and dietary habits in an elderly rural population in the southern Spain: the <i>Sierra de Huelva</i> study

Electrocardiographic Changes in Centenarians: A Study on 42 Subjects and Comparison with the Literature

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