Cardiovascular risk factors in patients with asymptomatic primary hyperparathyroidism

García-Martín, Antonia; Reyes-García, Rebeca; García-Castro, José Miguel; Quesada-Charneco, Miguel; Escobar-Jiménez, Fernándo; Muñóz-Torres, Manuel

doi:10.1016/j.endoen.2014.11.002

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…In addition, among the six instrumental variables for S-Ca levels, only two showed a positive association with T2DM, of which the SNP in the calcium-sensing receptor (rs1801725 in CASR) was significantly positively associated with T2DM. A positive association between that SNP and T2DM has also been shown in a previous study (6). A GWAS including up to 22,653 participants revealed the importance of rs73186030 (highly correlated with rs1801725) in the CASR gene in regulating S-PTH and S-Ca levels (16).…”

Section: Discussionsupporting

confidence: 73%

“…Studies on the association of S-Ca levels with T2DM are limited and inconsistent (5,6,36). The Atherosclerosis Risk in Communities study included 12,800 U.S. adults and observed a multivariableadjusted hazard ratio of T2DM of 1.26 (95% CI 1.07-1.48; P 5 0.004), comparing the highest and lowest S-Ca level quintile (6). Elevated S-Ca levels were also associated with an increased risk of diabetes in a retrospective cohort study of 6,096 Hong Kong Chinese adults (5).…”

Section: Discussionmentioning

confidence: 99%

“…However, the T2DMprotective effect of vitamin D was not observed in randomized controlled trials (3,4). In contrast to S-25OHD, observational studies have reported an increased risk of T2DM associated with elevated S-Ca (5) and S-PTH levels (6), but whether these associations are causal is uncertain due to the potential of residual confounding and reverse causality.…”

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confidence: 99%

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Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study

et al. 2019

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We conducted a Mendelian randomization study to investigate the associations of genetically predicted serum 25-hydroxyvitamin D (S-25OHD), calcium (S-Ca), and parathyroid hormone (S-PTH) levels with type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS Seven, six, and five single nucleotide polymorphisms (SNPs) associated with S-25OHD, S-Ca, and S-PTH levels, respectively, were used as instrumental variables. Data on T2DM were available for 74,124 case subjects with T2DM and 824,006 control subjects. The inverse variance-weighted method was used for the primary analyses, and the weighted median and Mendelian randomization (MR)-Egger methods were used for supplementary analyses. RESULTS Genetically predicted S-25OHD but not S-Ca and S-PTH levels were associated with T2DM in the primary analyses. For 1 SD increment of S-25OHD levels, the odds ratio (OR) of T2DM was 0.94 (95% CI 0.88-0.99; P 5 0.029) in an analysis based on all seven SNPs and 0.90 (95% CI 0.83-0.98; P 5 0.011) in an analysis based on three SNPs within or near genes involved in vitamin D synthesis. Only the association based on the SNPs involved in vitamin D synthesis remained in the weighted median analysis, and no pleiotropy was detected (P 5 0.153). Pleiotropy was detected in the analysis of S-Ca (P 5 0.013). After correcting for this bias using MR-Egger regression, the OR of T2DM per 1 SD increment of S-Ca levels was 1.41 (95% CI 1.12-1.77; P 5 0.003). CONCLUSIONS Modest lifelong higher S-25OHD levels were associated with reduced odds of T2DM, but the association was only robust for SNPs in the vitamin D synthesis pathway. The possible role of S-Ca levels for T2DM development requires further research. Vitamin D and parathyroid hormone (PTH) are the two major regulators of serum calcium (S-Ca) (1). Without vitamin D, only 10-15% of dietary calcium is absorbed, and vitamin D reduces renal calcium losses. PTH mobilizes calcium from the skeleton when S-Ca is reduced, and PTH also improves renal conservation of calcium. In addition to

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study

et al. 2019

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“…Although an association between PHPT and dyslipidemia has been reported [35,36], the exact relationship between the two entities is not fully understood. The findings of our study confirm these data showing that dyslipidemia is 2.7 times (p < 0.001) more common in patients with PHPT than in patients without this diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Hyperparathyroidism and Cardiovascular Disease: An Association Study Using Clinical Natural Language Processing Systems and Big Data Analytics

Iglesias,

Arias,

López

et al. 2023

JCM

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Primary hyperparathyroidism (PHPT) seems to be associated with different cardiovascular diseases (CVDs). We evaluated the association of PHPT with major CV risk factors (CVRFs) and CVDs by using artificial intelligence (AI) tools. An observational and retrospective study was conducted using data from the electronic health records (EHRs) of the Hospital Universitario Puerta de Hierro Majadahonda (Spain). Of a total of 699,157 patients over 18 years of age studied (54.7% females), 6515 patients (0.9%; 65.4% women; mean age 67.6 ± 15.9 years) had a diagnosis of PHPT. The overall frequencies of hypertension, dyslipidemia, diabetes mellitus, and smoking habit in the cohort of patients with PTHP were all significantly (p < 0.001) higher than those found in patients without a diagnosis of PTHP. The total frequency of stroke, ischemic heart disease, atrial fibrillation, deep vein thrombosis, and pulmonary embolism in the cohort of PHPT patients were significantly (p < 0.001) higher than that found in patients without the diagnosis of PHPT. A multivariate regression analysis showed that PHPT was significantly (p < 0.001) and independently associated with all the CVDs evaluated. Our data show that there is a significant association between the diagnosis of PHPT and the main CVRFs and CVDs in our hospital population.

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Incidental Hypercalcemia and the Parathyroid

Fisher

Perrier

2018

Journal of the American College of Surgeons

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Cardiovascular risk factors in patients with asymptomatic primary hyperparathyroidism

Cited by 7 publications

References 29 publications

Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study

Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study

Primary Hyperparathyroidism and Cardiovascular Disease: An Association Study Using Clinical Natural Language Processing Systems and Big Data Analytics

Incidental Hypercalcemia and the Parathyroid

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