Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy

Cardiovascular risk after hypertensive disorders of pregnancy in women with and without inheritable Thrombophilia

“…In the FRUIT-RCT, recurrent earlyonset HDP gestation was the primary outcome. For the current study, we used data of women who participated in the follow-up study of the FRUIT-RCT (26).…”

“…The control group of Bokslag et al was not used in the current study. The participants who were included in both studies were examined in the Netherlands in the period between 2014 and 2016 (4,26). The data of these examinations were used in the current study.…”

“…Eclampsia was defined as generalized convulsions in pregnancy in the absence of epilepsy and HELLP syndrome is a combination of hemolysis (LDH ≥ 600 IU/L), elevated liver enzymes (increased serum glutamic oxaloacetic transaminase/serum glutamic pyruvic transaminase ≥70 IU/L) and thrombocytopenia (<100 x 10 9/L ) (3). Increased cardiovascular risk was defined as the presence of either hypertension, hypercholesterolemia, BMI > 25 kg/m2 or DM (26). Hypertension was defined as the current use of blood pressure lowering medication or de novo systolic blood pressure ≥ 140 or diastolic blood pressure ≥ 90 mmHg.…”