Cardiovascular risk factors in women 10 years post early preeclampsia: the Preeclampsia Risk EValuation in FEMales study (PREVFEM)

Drost, José T.; Arpaci, Ganiye; Ottervanger, Jan Paul; Boer, Menko Jan de; Eyck, Jim van; Schouw, Yvonne T. van der; Maas, Angela H.E.M.

doi:10.1177/1741826711421079

Cited by 102 publications

(109 citation statements)

References 32 publications

Supporting

Mentioning

101

Contrasting

Order By: Relevance

“…The present study is a four-year follow-up of the PREVFEM study [2]. The PREVFEM historical cohort study was set up in 2009 to examine cardiovascular risk factors in women with a history of early PE.…”

Section: Participants and Proceduresmentioning

confidence: 99%

“…The PREVFEM historical cohort study was set up in 2009 to examine cardiovascular risk factors in women with a history of early PE. In 2009, all pregnancies that were registered in the Isala hospital records between the years 1991 and 2007 were screened for presence (exposure) or absence (nonexposure) of early onset PE [2,20]. Inclusion criteria for the PE group were early onset PE as defined according to the International Society for the Study of Hypertension in Pregnancy (ISSHP) definition; an elevated diastolic blood pressure !90 mmHg with proteinuria (!0.3 g/24 h) between 20 and 32 weeks of gestation during index pregnancy.…”

Section: Participants and Proceduresmentioning

confidence: 99%

“…It comprises 12 items on a 0-4 scale, and items 3, 8, 9, and 12 are reverse scored. Four filler items [2,6,7,10] are not included in the total score. A higher score indicates more dispositional optimism [26].…”

Section: Psychosocial Distressmentioning

confidence: 99%

“…The Preeclampsia Risk EValuation in FEMales (PREVFEM) historic cohort study showed increased hypertension (OR 3.59, 95% CI 2.48-5.20) on average 10 years after the index pregnancy, in women with a history of early onset (20-32 weeks gestation) PE compared to a comparison group without PE [2]. Other studies have consistently shown associations between a history of PE with cardiovascular outcomes, including hypertension, diabetes, ischemic heart disease, stroke, and renal failure, and PE is now an emerging risk factor for future cardiovascular disease (CVD) [2][3][4][5][6][7][8]. It is suggested that PE and CVD share common cardiac risk factors such as hypertension, obesity, dyslipidemia, and hyperglycemia/insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Long-term follow-up of psychosocial distress after early onset preeclampsia: the Preeclampsia Risk EValuation in FEMales cohort study

Mommersteeg

Drost

Ottervanger

et al. 2016

Journal of Psychosomatic Obstetrics & Gynecology

Self Cite

View full text Add to dashboard Cite

Objective: To examine long-term psychosocial distress in women with a history of early onset preeclampsia (PE) compared to a comparison group. Methods: Women with and without a history of early onset PE participating in the 'Preeclampsia Risk EValuation in FEMales' (PREVFEM) study were sent questionnaires, on average 14.1 years (SD ¼ 3.2, range 5-23 years) after the index pregnancy. In total 265 (77%) women with PE and 268 (78%) age-matched women without PE returned questionnaires (mean age 43.5, SD ¼4.6 years). Group differences were examined on indicators of psychosocial distress, depressive symptoms, anxiety, fatigue, loneliness, marital quality, trait optimism and Type D personality, and unadjusted and adjusted for a priori chosen and study-specific covariates. In secondary analyses, the effect of previously detected hypertension was examined, as well as pregnancy-related events within the PE group. Results: Women with a history of PE reported more subsequent depressive symptoms (B ¼ 0.70, 95% CI 0.09-1.32, p ¼ 0.026) and more fatigue (B ¼ 1.12, 95% CI 0.07-2.18, p ¼ 0.037) compared to the non-PE group, but the differences explained less than 1% of the variance. The differences remained after adjustment for age, BMI and education level, and additional adjustment for partner, being unemployed and physical activity. No significant differences were observed for anxiety, loneliness, marital quality, optimism, or Type D personality. These differences were not explained by fouryear previously measured elevated blood pressure in the PE group. Having had a stillborn child or early neonatal death during the index pregnancy was associated with higher depressive symptoms, anxiety, fatigue, and loneliness in the PE group, but these factors explained only a small proportion of the variance in these psychosocial distress factors. Conclusion: A history of early PE is associated with slightly higher levels of depressive symptoms and fatigue on average 14 years later, but this is unlikely to be of clinical relevance. ARTICLE HISTORY

show abstract

Section: Participants and Proceduresmentioning

confidence: 99%

Section: Participants and Proceduresmentioning

confidence: 99%

Section: Psychosocial Distressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term follow-up of psychosocial distress after early onset preeclampsia: the Preeclampsia Risk EValuation in FEMales cohort study

Mommersteeg

Drost

Ottervanger

et al. 2016

Journal of Psychosomatic Obstetrics & Gynecology

Self Cite

View full text Add to dashboard Cite

show abstract

“…11 Moreover, metabolic syndrome was more prevalent in women post preeclampsia. 12 Hence, again -our study by identifying altered biological functions and pathways is a first step in establishing prevention measures against CVDs in mothers after preeclampsia. Overall, we propose that treating preeclampsia, i.e.…”

Section: Commentmentioning

confidence: 99%

Long-term Alterations in Maternal Plasma Proteome After sFlt1-induced Preeclampsia in Mice

Bytautiene

Bulayeva

Bhat

et al. 2014

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

Objective-Preeclampsia (PE) is associated with long-term adverse maternal health, such as cardiovascular (CVD) and metabolic diseases. The objective of this study was to determine whether PE in a well characterized animal model induced by over-expression of sFlt-1 results in alterations in the maternal circulating proteome that persist long after delivery.Methods-CD-1 mice at day 8 of gestation were injected with adenovirus carrying sFlt1 or the murine IgG2α Fc fragment as control. Depleted maternal plasma was analyzed 6 months after delivery by label-free liquid chromatography -mass spectrometry assay. The tandem MS data were searched against a mouse database and the resultant intensity data were used to compare abundance of proteins across disease/control plasma pool (MaxQuant/Mascot). Results were analyzed using Ingenuity Pathways Analysis (IPA). Right-tailed Fisher's exact test was used to calculate a P-value.Results-Out of 150 proteins common for both groups, IPA determined 105 proteins ready for analysis. Diseases and disorders analysis showed significant enrichment of proteins associated with CVD. Within this cluster, the most abundant proteins were associated with vascular disease, atherosclerosis and atherosclerotic lesions. Other top disease clusters were inflammatory response, organismal injury and abnormalities, hematological and metabolic disease.Conclusions-Exposure to sFlt1-induced preeclampsia alters multiple biological functions in mothers that persist later in life. Our results suggest that some of the long term adverse outcomes associated with preeclampsia may actually be a consequence of an underlying predisposition. If similar results are found in humans, developing preventive strategies for preeclampsia should also improve long term maternal health.

show abstract

Implications for the Mother with Diabetes

Wender-Ożegowska

Sacks

2017

A Practical Manual of Diabetes in Pregnancy

View full text Add to dashboard Cite

Cardiovascular risk factors in women 10 years post early preeclampsia: the Preeclampsia Risk EValuation in FEMales study (PREVFEM)

Abstract: We found a high prevalence of hypertension in young women at 10 years post early preeclampsia. More research on the timing of cardiovascular screening in these high-risk women is needed.

Cited by 102 publications

References 32 publications

Long-term follow-up of psychosocial distress after early onset preeclampsia: the Preeclampsia Risk EValuation in FEMales cohort study

Long-term follow-up of psychosocial distress after early onset preeclampsia: the Preeclampsia Risk EValuation in FEMales cohort study

Long-term Alterations in Maternal Plasma Proteome After sFlt1-induced Preeclampsia in Mice

Implications for the Mother with Diabetes

Contact Info

Product

Resources

About