Cardiovascular risk factors profile in patients with acute coronary syndrome with particular reference to left ventricular ejection fraction

Abstract

We concluded that DM, presence of significant ischemic MR, and increased number, severity of diseased coronaries all were independent predictors of LV dysfunction (LVEF <40%) which is known to predict poor outcome. Identification of those risk predictors upon patient evaluation could be helpful to identify high risk-patients, in need of particular care, aggressive therapy and close follow-up to improve their poor outcome.

Assessment of the Diagnostic Accuracy of C-Reactive Protein and Pentraxin3 in Acute Coronary Syndrome Compared with Cardiac Troponin-1

“…Regarding to LVEF, a high statistically significant difference between both groups with p value ≤0.001 as the mean LVEF was 53.63±5.57 in ACS group and 58.33±5.13 in Non-ACS group. This was concordant with, [13] in which there was significant difference regarding LVEF G.Paramasivam [14] stated that there was no statistical significant difference regarding LVEF. It was 51 ± 10 in ACS group and 54 ± 11 in Non ACS group with p value 0.076 which is disconcordant with our study.…”

Are proton pump inhibitors among the risk factors for acute coronary syndrome?

“…A cute coronary syndrome (ACS) remains one of the chief causes of death worldwide. 1 Hypertension, dyslipidemia, obesity, smoking, and diabetes are considered risk factors for cardiovascular diseases such as ACS. 2 In Saudi Arabia, approximately 50% of people live with 3 or more cardiovascular (CV) risk factors.…”

Evaluation of cardiometabolic risk markers linked to reduced left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI)

“…The diagnosis and classification of ACS are made according to clinical manifestations, electrocardiogram (ECG) results, angiographic analysis, and myocardial necrosis serum markers [ 2 , 4 – 6 ]. The currently available experimental and clinical evidence identified inflammation and the associated plaque rupture and plaque erosion, endothelial or microvascular dysfunction, and vasospasm predominantly in the epicardial arteries, as the main mechanisms involved in ACS pathogenesis [ 2 , 5 – 8 ]. There are also additional factors including innate and adaptive immune system activation, coronary blood flow, and increased count of leukocytes (including neutrophils to lymphocytes counts ratio), that could affect the progression of ACS [ 2 , 5 – 8 ].…”

“…The currently available experimental and clinical evidence identified inflammation and the associated plaque rupture and plaque erosion, endothelial or microvascular dysfunction, and vasospasm predominantly in the epicardial arteries, as the main mechanisms involved in ACS pathogenesis [ 2 , 5 – 8 ]. There are also additional factors including innate and adaptive immune system activation, coronary blood flow, and increased count of leukocytes (including neutrophils to lymphocytes counts ratio), that could affect the progression of ACS [ 2 , 5 – 8 ]. Additionally, hypertension, hyperglycemia, hyperlipidemia, obesity, elevated pro-inflammatory cytokines, chronic kidney impairment, and other cardiometabolic risk factors seem to be linked with many of these processes, thus increasing the risk of vascular instability and atherosclerosis [ 2 , 5 , 6 , 9 ].…”

“…There are also additional factors including innate and adaptive immune system activation, coronary blood flow, and increased count of leukocytes (including neutrophils to lymphocytes counts ratio), that could affect the progression of ACS [ 2 , 5 – 8 ]. Additionally, hypertension, hyperglycemia, hyperlipidemia, obesity, elevated pro-inflammatory cytokines, chronic kidney impairment, and other cardiometabolic risk factors seem to be linked with many of these processes, thus increasing the risk of vascular instability and atherosclerosis [ 2 , 5 , 6 , 9 ]. It is well documented that the ventricular systolic dysfunction during ACS is an important clinical manifestation leading to worse outcomes [ 10 – 12 ].…”