Cardiovascular  risk  in  patients  with  inflamma-tory bowel diseases: a review

Manea, Maria Mirabela; Marcu, Dragoș; Motofei, Ion G.; Socea, Bogdan; Stoian, Anca Pantea; Bratu, Ovidiu Gabriel; Găman, Mihnea‐Alexandru; Găman, Amelia Maria; Stănescu, Ana Maria Alexandra; Nicorici, Lucia Mazur; Diaconu, Camelia Cristina

doi:10.25083/rbl/24.2/366.373

Cited by 11 publications

(9 citation statements)

References 52 publications

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“…A systematic review across 33 studies found no increased risk of arterial TEs (relative risk: 1.15, 95% CI 0.91, 1.45) [21]. However, to date, results regarding the risk of arterial TEs in patients with IBD have been inconsistent due to factors such as type of arterial TE, severity of IBD and patient characteristics [4,21,22]. The baseline period was defined as 1-year period prior to the index date b…”

Section: Discussionmentioning

confidence: 99%

Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease

Setyawan

Zichlin

et al. 2021

Adv Ther

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Introduction: Inflammatory bowel disease (IBD) is associated with greater risk of thromboembolic events (TEs) due to the link between systemic inflammation and hypercoagulability. This study assessed the rates of TEs among patients with IBD versus patients without immune-mediated disease (IMD) and the cost of TEs among patients with IBD in the United States.Methods: This study used the IBM MarketScan Ò Commercial and Medicare Supplemental Databases (2014Databases ( -2018. To assess the incremental rates of TEs (deep vein thrombosis [DVT], pulmonary embolism [PE], ischemic stroke [IS], myocardial infarction [MI]), patients with IBD were matched to patients without IMD. Unadjusted and adjusted incidence rate ratios (IRRs) of TEs were used to compare cohorts. To assess the cost of TEs, patients with IBD with TEs were matched to patients with IBD without TEs. Costs were assessed 30 days and 1 year post index date. Results: There were 34,687 matched pairs included in the rates of TE analyses. Compared to patients without IMD, patients with IBD had greater rates of DVT (adjusted IRR [95% confidence interval] 2.44 [2.00, 2.99]; p \ 0.01) and PE (1.90 [1.42, 2.54]; p \ 0.01). Increased rates were not observed for IS and MI. There were 1885 matched pairs included in the cost of TE analyses. Patients with IBD with TEs incurred greater healthcare costs over 30 days and 1 year versus patients without TEs (adjusted total cost difference: 30 days $20,784; 1 year $44,630; p \ 0.01 for both). Conclusions: Patients with IBD experienced greater rates of DVT and PE compared to patients without IMD; this elevated risk was associated with a substantial economic burden.

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Section: Discussionmentioning

confidence: 99%

Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease

Setyawan

Zichlin

et al. 2021

Adv Ther

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“…Patients who experience fatigue also evaluate their disease as having more negative consequences and a higher emotional impact, than patients who do not experience this symptom. This is understandable as fatigue has crippling effects on one's social and work life, also impacting the general well-being (29,30).…”

Section: Discussionmentioning

confidence: 99%

Psychosocial profile of the patients with inflammatory bowel disease

et al. 2020

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Inflammatory bowel disease (IBD) is a chronic, disabling entity of unknown aetiology, with negative impact on the patient's life, including psychological patterns. This study assessed multiple psychosocial factors (satisfaction with life, coping mechanisms, emotional profile, mental recognition of the disease and cognition schemes related to patients' demographic characteristics, clinical picture, form and duration of the disease, therapeutic plans) in IBD patients vs. a healthy group. This non-interventional study comprised 60 participants who attended for medical advice/check-up as an ambulatory visit or during hospitalization. The patients completed questionnaires after receiving explanations from the psychologist. Statistical analyses (Kolmogorov-Smirnov test, Independent-Samples t-test, One-Way ANOVA and Post Hoc Multiple Comparisons) were conducted using IMB for the Social Sciences (SPSS), version 20 (P≤0.05). IBD patients (G1) are more hostile when compared to the healthy group (G2). Those who experience abdominal pain are more likely to use active coping mechanisms and those who experience fatigue are more likely to use acceptance, emotional venting, behavioural disengagement and mental disengagement. G1 have higher levels of others-downing vs. G2. Regarding negative emotions, IBD patients generally experience more negative emotions compared to healthy participants (who have higher levels of life satisfaction). Regarding the perception of illness, there are no differences between patients in terms of illness coherence, personal or treatment control, consequences, timeline, or emotional representations. Results indicate that psychological factors and different characteristics of IBD patients play a relevant role in the way these patients deal with their disease.

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“…Many studies suggest that patients with IBD have an increased risk for developing myocardial infarction and stroke 15,16 . In addition, these patients are at high risk of developing cardiovascular events in the perioperative period, and they are in need for a specifi c anesthesia and intensive care management, especially related to surgery [17][18][19] .…”

Section: Surgical Indications and Optionsmentioning

confidence: 99%

Inflammatory Bowel Diseases: the Surgical Perspective

Socea¹,

Dumitrescu²,

Bratu³

et al. 2019

Rev. Med. Mod.

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Inflammatory bowel diseases (IBD), namely Crohn's disease and ulcerative colitis, are relatively rare diseases in our country, known as a low prevalence geographic region. IBD are a multidisciplinary problem, that implies gastroenterologists, as well as surgeons. Surgical management in inflammatory bowel disease is often impaired by a high complication rate and a signifi cant recurrence rate, specifi c mostly for Crohn's disease. Indications for surgery include failure of medical therapy (including delayed puberty for young patients and drug intolerance), toxic megacolon, bowel perforation, obstruction, enteric fi stula and abdominal or perianal abscess. Advances in medical treatment options for IBD are continuously accumulating. However, a large number of patients still require surgical procedures during lifetime. RezumatBolile inflamatorii intestinale, cuprinzând boala Crohn și colita ulcerativă, sunt boli relativ rare în ţara noastră, cunoscută ca o regiune geografi că cu prevalenţă scăzută. Bolile inflamatorii intestinale reprezintă o problemă multidisciplinară, care implică atât gastroenterologi, cât și chirurgi. Abordarea chirurgicală în bolile inflamatorii intestinale este adesea afectată de o rată ridicată a complicaţiilor și de o rată semnifi cativă de recurenţă, specifi că mai ales pentru boala Crohn. Indicaţiile intervenţiilor chirurgicale includ eșecul terapiei medicamentoase (inclusiv pubertatea întârziată pentru pacienţii tineri și intoleranţa la medicamente), megacolonul toxic, perforaţiile intestinale, ocluzia, fi stula enterică și abcesul abdominal sau perianal. Opţiunile de tratament medicamentos în bolile inflamatorii intestinale se perfecţionează continuu. Cu toate acestea, un număr mare de pacienţi încă necesită proceduri chirurgicale de-a lungul vieţii. Cuvinte cheie: boli inflamatorii intestinale, boala Crohn, colita ulcerativă, chirurgie. REVIEW

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Cardiovascular risk in patients with inflamma-tory bowel diseases: a review

Cited by 11 publications

References 52 publications

Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease

Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease

Psychosocial profile of the patients with inflammatory bowel disease

Inflammatory Bowel Diseases: the Surgical Perspective

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