Cardiovascular Risk in Psoriasis Patients: Clinical, Functional and Morphological Parameters

Abstract

BackgroundPsoriasis correlates with metabolic disorders, early atheromatosis and increased cardiovascular risk.ObjectivesTo assess markers of cardiovascular disease in psoriatic patients.MethodsCross-sectional, observational study involving 11 psoriatic participants and 33 controls. Anthropometric, biochemical, hemodynamic and imaging parameters were evaluated. Arterial stiffness was assessed by oscillometric measurement of the brachial artery. Intima-media thickness (IMT) and left ventricular diastolic function were assessed by Doppler echography and echocardiography. Between-group comparisons of numerical variables were performed by the Student’s t-test or Wilcoxon Mann-Whitney test for independent samples. Significance level was set at 5%.ResultsPsoriatic patients showed increased pulse wave velocity (PWV) (9.1 ± 1.8 vs 8.0 ± 2 m/s, p = 0.033), IMT of the left common carotid artery (p = 0.018) and a higher percentage of patients above the 75th percentile according to the ELSA table when compared with controls (54.5 vs 18.2%, p = 0.045). Psoriatic patients also showed an increase in peripheral/central systolic blood pressure (137.1 ± 13.2 vs 122.3 ± 11.6 mmHg, p = 0.004)/(127 ± 13 vs 112.5 ± 10.4 mmHg, p = 0.005), peripheral/central diastolic blood pressure (89.9 ± 8.9 vs 82.2 ± 8, p = 0.022)/(91 ± 9.3 vs 82.2 ± 8.3, p = 0.014), total cholesterol (252 ± 43.5 vs 198 ± 39.8 mg/dL, p < 0.001), LDL cholesterol (167 ± 24 vs 118 ± 40.8 mg/dL, p < 0.001) and C-reactive protein (7.6 ± 35.4 vs 1 ± 1.2 mg/L p < 0.001) compared with controls.ConclusionPsoriasis patients show increased PWV, IMT, peripheral and central blood pressures, and serum cholesterol and C-reactive protein levels, denoting a higher cardiovascular risk.

Changes in arterial stiffness in children and adolescents during the period of social restrictions due to the COVID-19 pandemic

“…Thus, several studies have shown changes in AIx@75 without signi cant changes in PWV in children, which corroborates our ndings [13,14,18,20]. The inverse of this process occurs in older individuals, where PWV increases and AIx changes slightly, which suggests that the increase in AP would be driven by an earlier return of the re ected wave and a less compliant aorta rather than predominant changes in the magnitude of wave re ection [12,40]. It is expected that in situations where there is an increase in AIx, the DBPc will be reduced, as was observed in our study of the APG.…”

“…Currently, efforts have been made to nd early markers of cardiovascular disease so that timeous intervention can be carried out to reduce the development and progression of cardiovascular diseases, thus highlighting the importance of investigating arterial stiffness [11]. Possible early cardiovascular risk markers include pulse wave velocity (PWV), considered a great indicator of arterial stiffness, [12] and the augmentation index normalized to a heart rate of 75 beats per minute (AIx@75), an independent predictor of future cardiovascular events and mortality [13,14].…”

Exploring the role of systemic immune‐inflammation index and neutrophil‐lymphocyte ratio in cardiovascular risk stratification for patients with hidradenitis suppurativa: A cross‐sectional study

“…1,2 In this regard, different techniques have been used to stratify the cardiovascular risk of patients with inflammatory skin diseases, such as carotid ultrasonography 3,4 and pulse wave velocity. 3 Regarding ultrasonography, the measurement of the intimamedia thickness (IMT) in the common carotid artery of patients with HS has been reported to be associated with higher burden…”

“Conheça o seu Inimigo e a si Mesmo”. Risco Cardiovascular na Pesquisa Nacional de Saúde

“…They found that more than one-fourth of those participants had >20% probability of cardiovascular events in 10 years. Oliveira et al 8 studied 11 consecutive male patients with psoriasis (an inflammatory disorder also associated with increased cardiovascular risk 9 ) and 33 age-matched controls and found significantly higher total cholesterol, LDL-cholesterol and C-reactive protein levels and a trend towards higher frequencies of smoking and hypertension diagnosis in individuals with psoriasis compared to controls.…”