Cardiovascular Risk Profile in Dupuytren’s Disease: A Systematic Review and Meta-Analysis.

Abstract

Background. Patients with Dupuytren’s disease (DD) may have a higher cardiovascular (CV) risk because of association with diseases with a higher recognized CV risk, such as diabetes. However, DD is not always linked to these diseases; therefore, it seems relevant to assess the CV profile in DD.Methods. We performed a systematic literature review up to April 2020. Differences between DD patients and controls were expressed as standardized mean differences using the inverse-variance method or as odds ratios (ORs) using the Mantel-Haenszel method. Results. We obtained 51 references corresponding to 112,900 DD patients and 2,383,177 controls. We found a higher risk of death (OR=1.72 [95%CI:1.37-2.16]) and CV death (118/974 DD patients vs. 372/3948 controls; OR=1.33 [95%CI:1.07-1.66]) among DD patients compared to controls. DD patients were more often diabetic (OR=3.44 [95% CI:2.69-4.38]). In 17 studies of the general population, the incidence of diabetes was 17.5% among DD patients (11.7-24.2%). DD patients were older, and more often men or alcohol drinkers. The percentage of smokers and levels of blood pressure or total cholesterol were not different among DD patients and controls. No difference was found in triglycerides, but the risk of obesity was significantly lower in DD patients.Conclusions. We found a higher CV risk in DD but not a higher prevalence of CV risk factors, except diabetes. This may be due to the predominance of men or greater number of alcohol drinkers or diabetics. Management of CV risk is important in patients with DD, including research on alcohol consumption or diabetes.