Cardiovascular risk profile in patients with myelopathy associated with HTLV-1

Prado, Fábio Luis Silva do; Prado, Renata de Andrade; Ladeia, Ana Marice

doi:10.1016/j.bjid.2017.01.007

Cited by 2 publications

(3 citation statements)

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“…These data are in consistent with prior cross-sectional studies that did not demonstrate consistent associations between traditional cardiovascular risk factors [34], lipid levels, and HTLV serostatus [22]. In a study that evaluated lipid alterations in women infected with HTLV1, increased levels of very low-density lipoproteins and triglyceride were found in the women with HTLV1 and HAM/TSP groups as compared with healthy subjects [35].…”

Section: Discussionsupporting

confidence: 90%

“…TNFα plays a key role in the metabolism of lipid, insulin resistance, endothelial function, and coagulation, and particularly TNFα 1031 allele C was correlated with CVD risk and dyslipidemia [32,33]. However, consistent to our findings in other studies, serum hs-CRP and IL-6 were not significantly associated with the risk of CVD in the HAM/TSP patients [22]. Thus, other factors such as lipid alter ations may contribute to pathogenesis of CVD in chronic HTLV infection.…”

Section: Discussionsupporting

confidence: 85%

“…There are limited data evaluating cardiovascular risk in individuals with HTLV1 infection [22]. Herein, we assessed HDL lipid peroxidation as a surrogate measure of HDL dysfunction and a predictor of CVD in the MASHAD cohort study.…”

Section: Discussionmentioning

confidence: 99%

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Human T lymphotropic virus type 1 and risk of cardiovascular disease: High‐density lipoprotein dysfunction versus serum HDL‐C concentrations

et al. 2019

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High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited. Anthropometric and biochemical parameters including serum hs-CRP, fasted lipid profile (HDL-C, LDL, triglycerides, and cholesterol), and fasting blood glucose were determined. Serum HDLox was also measured in the study participants. Multivariate analyses were used to evaluate the association between serum HDLox and HTLV1 infection. None of the traditional CVD risk factors were associated with HTLV1 infection, including serum HDL-C. However, serum HDLox was independently associated with the presence of HTLV1 infection. Logistic regression analysis showed that subjects who were positive for HTLV1 infection were also significantly more likely than uninfected individuals to have higher HDLox (odds ratio 9.35, 95%CI: 3.5–24.7; P < 0.001). HDLox was increased approximately 20% (P < 0.001) in infected subjects compared to the uninfected group. Serum HDLox is a marker of CVD risk factor and increased in individuals affected by HTLV1 infection compared to healthy subjects.

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Section: Discussionsupporting

confidence: 90%