Cardiovascular Side-Effects of Modern Cancer Therapy

Minami, Manabu; Matsumoto, Shigemi; Horiuchi, Hisanori

doi:10.1253/circj.cj-10-0632

Cited by 66 publications

(43 citation statements)

References 60 publications

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“…CT includes cytotoxic agents, hormonal blockers, and receptor specific targeted therapy. Depending on the drug and administration cycle, these drugs effect normal cell reproduction and often lead to myelosuppression, immunosuppression, mucositis, and alopecia and in some cases the adverse effect may be fatal [8]. In the rehabilitation setting, detailed documentation including complete blood counts of these conditions is considered essential in the development of the exercise prescription.…”

Section: Chemotherapy (Ct) Induced Pathologymentioning

confidence: 99%

“…It is well documented that tumorgenesis and cancer treatment is associated with adverse physical and physiological changes leading to metabolic and functional modifications, inducing pathologies of the cardiac, pulmonary, neural, bone and skeletomuscular systems [2]. These alterations effect cardiorespiratory capacity (fitness), strength, body composition, and physical function including immune system integrity, peripheral neuropathy, and quality of life [3][4][5][6][7][8]. However, it is increasingly clear that prescribing exercise during and post-cancer treatment may mitigate many of these adverse changes (Table 1) by decreasing tissue inflammation contributing to tumorgenesis [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Implementation of Exercise Guidelines for Cancer Patients: Adaptation of ACSM’s Guidelines to the Italian Model

Stefani

Galanti

Klika

2017

JFMK

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Abstract:The goal of cancer treatment is to arrest or eradicate the tumor while minimizing the often toxic effects of treatment. While oncologic diagnostics and treatments are improving and survival rates are increasing, it is critical to provide additional patient management that appears to affect long-term survival. Epidemiologic evidence suggests patients diagnosed with cancer tend to fair better after treatment when following a comprehensive rehabilitation program aimed at achieving an ideal body weight through dietary and exercise interventions while also increasing cardiorespiratory fitness, strength, mobility, neuromuscular integrity and psycho-social wellbeing. Additionally, it is now being tested whether exercise during cancer treatment and possibly prior to the start of treatment may increase post treatment outcomes by altering body weight, having direct effects on tumorigenesis, reducing oxidative stress and inflammation, and perhaps increasing chemotherapy delivery efficacy. The purpose of this review is to outline an evidence based model to evaluate cancer patients and provide guidelines for post-cancer treatment rehabilitation programs. Additionally, strategies aimed at changing lifestyle habits such as smoking and poor dietary habits will be addressed.

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Section: Chemotherapy (Ct) Induced Pathologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Implementation of Exercise Guidelines for Cancer Patients: Adaptation of ACSM’s Guidelines to the Italian Model

Stefani

Galanti

Klika

2017

JFMK

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“…3 However, several treatment related adverse effects have become important issues for cancer survivors. 4 Chemotherapy has been one of the mainstays of treatment in patients with cancer, and cancer patients receive a cocktail of chemotherapy drugs. Chemotherapy may exert adverse effects on various organs.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Assessment of Left Ventricular Function in Patients Undergoing Chemotherapy by 2d Strain Imaging.

Patted¹,

Porwal²,

Ambar³

et al. 2018

IJAR

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“…Many anticancer drugs are cardiotoxic, and it is well known that both anthracycline antibiotics and trastuzumab cause congestive heart failure. 1) Five-fluorouracil (5-FU) is one of the most important chemotherapeutic agents used to treat many solid tumors, including colorectal cancer; however, it has several adverse effects.…”

mentioning

confidence: 99%

Capecitabine Induces Both Cardiomyopathy and Multifocal Cerebral Leukoencephalopathy

et al. 2013

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SummaryChemotherapy for malignant tumors has diversifi ed, and recognizing its side effects has become more important than ever. Both cardiotoxicity and neurotoxicity are rare, but they are among the most serious side effects caused by 5-fl uorouracil (5-FU). Capecitabine is an orally administered prodrug that converts preferentially to 5-FU within tumors, resulting in enhanced concentrations of 5-FU in tumor tissue. Given that it targets tumor tissue, capecitabine was expected to reduce the risk of side effects associated with fl uoropyrimidine. Here, we present the case of a 62-year-old man with colorectal adenocarcinoma who simultaneously experienced cardiomyopathy with cardiogenic shock and cerebral leukoencephalopathy during treatment with capecitabine. During emergency coronary angiography, ST-segment elevation and severely reduced left ventricular wall motion were observed; however, no severe coronary stenosis or spasm was revealed. Furthermore, we present a review of the literature on capecitabine-induced cardiotoxicity. As of April 2013, 39 case reports on capecitabine-induced cardiotoxicity have been published; however, cardiomyopathy was very rare, with only 3 cases reported. It is important for physicians to be aware of the various rare, but potentially serious, adverse effects associated with capecitabine chemotherapy and to inform patients about the possibility of these side effects, including cardiotoxicity and neurotoxicity. (Int Heart J 2013; 54: 417-420) Key words: Chemotherapy, Cardiotoxicity, Neurotoxicity R ecently, chemotherapy for malignant tumors has diversifi ed, and recognizing the side effects of chemotherapy as well as its curative effects has become more important than ever. Many anticancer drugs are cardiotoxic, and it is well known that both anthracycline antibiotics and trastuzumab cause congestive heart failure.1) Five-fluorouracil (5-FU) is one of the most important chemotherapeutic agents used to treat many solid tumors, including colorectal cancer; however, it has several adverse effects.2) Cardiotoxicity 3) and cerebral leukoencephalopathy 4) are rare side effects of 5-FU therapy, but are among the more serious side effects associated with this therapy. Capecitabine, an orally administered fl uoropyrimidine carbamate, is a 5-FU prodrug that was developed to lessen the side effects associated with 5-FU therapy.5) Oral 5-FU often causes intestinal tract toxicity, and oral administration of high-dose 5-FU raises the concentration of the drug in the intestinal tract; therefore, intestinal tract toxicity is often the dose-limiting factor. Capecitabine itself is not cytotoxic, but it becomes effective after it has been converted to 5-FU in tumor cells. 5,6) It is widely used because it can be orally administered and is associated with fewer side effects.2) However, as the use of capecitabine becomes more widespread, its side effects, including cardiotoxicity, appear to be similar to those of 5-FU.3,7) We report a case of cardiomyopathy mimicking acute coronary syndrome that coin...

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Cardiovascular Side-Effects of Modern Cancer Therapy

Cited by 66 publications

References 60 publications

Clinical Implementation of Exercise Guidelines for Cancer Patients: Adaptation of ACSM’s Guidelines to the Italian Model

Clinical Implementation of Exercise Guidelines for Cancer Patients: Adaptation of ACSM’s Guidelines to the Italian Model

Assessment of Left Ventricular Function in Patients Undergoing Chemotherapy by 2d Strain Imaging.

Capecitabine Induces Both Cardiomyopathy and Multifocal Cerebral Leukoencephalopathy

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