Cardiovascular studies on aminocaproic acid

Cummings, John R.; Welter, Alphonse N.

doi:10.1016/0041-008x(66)90030-5

Cited by 9 publications

(1 citation statement)

References 12 publications

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“…However, in EACA-treated dogs, the hematocrit increased immediately after thrombapplastin injection. This is in accordance with the report of Cummings and Welter (1966), who found intravenous administration of large amounts of aminocaproic acid to evoke a syndrome resembling deshydremic shock, with decreased total peripheral resistance. oedema and hemuconcentration.…”

Section: Discussionsupporting

confidence: 93%

Effects of Epsilon Aminocaproic Acid (EACA) and Trasylol on Thromboplastin‐Induced Intravascular Coagulation, Studied in Dogs with Iodine‐Labelled Fibrinogen

Nordström

Zetterqvist

1969

Acta Physiologica Scandinavica

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The elimination of iodine‐labelled fibrinogen was followed in 3 groups of dogs after: 1. thromboplastin infusion, 2. simultaneous infusions of thromboplastin and epsilon aminocaproic acid (EACA), and 3. simultaneous infusions of thromboplastin and Trasylol. Platelet count, fibrinogen concentration, radioactivity in plasma and in fibrinogen as well as hematocrit were determined. Thromboplastin caused changes of the same type as those previously obtained with thrombin, indicating the development of a fibrinolytic process, secondary to intravascular coagulation. The secondary changes were effectively blocked by pretreatment with EACA and Trasylol. The incidence of and mortality in thromboembolism suggest some anticoagulant effect of Trasylol. The antifibrinolytic activity of Trasylol is much stronger than the anticoagulant one. EACA too, seems to give some protection against thromboplastin‐induced coagulation.

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Section: Discussionsupporting

confidence: 93%