Care for children with haemophilia during COVID‐19: Data of the PedNet study group

Álvarez-Roman, Teresa; Kurnik, Karin

doi:10.1111/hae.14286

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Studies have shown that the COVID-19 pandemic had a negative impact on lifestyle behaviors, routine care, and replacement therapies in patients with CBD [15][16][17][18]. However, there are only a limited number of clinical studies that have investigated the outcomes of COVID-19 in patients with bleeding disorders, and it is not known whether patients with bleeding disorders are more or less prone to the severe form of infection.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

Mericliler¹,

Narayan²

2022

Cureus

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BackgroundHypercoagulability is a major pathologic event in COVID-19. Factor VIII plays an important role in hemostasis, and high levels of factor VIII have been shown to be associated with an increased risk of thrombosis and severe disease. Little is known about the impact of COVID-19 on clinical outcomes in patients with hemophilia A. MethodologyRetrospective data of adult male patients with COVID-19 with and without hemophilia A were retrieved from the TriNetX database (Cambridge, USA). The 1:1 propensity score-matching was performed to balance baseline characteristics. Patients were matched for age, race, body mass index, and medical comorbidities. Thirty-day outcomes were assessed. ResultsWe identified 1,758 patients with pre-existing hemophilia A diagnosis prior to COVID-19 diagnosis and 5,191,908 comparators. After 1:1 propensity score matching, groups were balanced on demographics and comorbidities. All-cause mortality rates were similar between the two groups (HR 0.805; 95% CI 0.467-1.389). The frequency of severe infection, ICU admission, and composite thrombotic events did not differ between the groups. Patients with hemophilia A were hospitalized more frequently than those without a history of hemophilia A (19.2% vs. 14.4%; p<0.05). Additionally, gastrointestinal (GI) bleeding and composite bleeding events occurred more frequently in patients with hemophilia A (3.2% vs. 2.2%; p<0.05 and 4.0% vs. 2.8%; p<0.05, respectively). ConclusionsThe mortality of individuals with hemophilia A due to COVID-19 is comparable to the general population but with higher risks of hospitalization and bleeding.

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Section: Discussionmentioning

confidence: 99%

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

Mericliler¹,

Narayan²

2022

Cureus

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A multidisciplinary approach to optimising the virtual management of haemophilia: a roundtable meeting of UK experts

Benson,

Bhandari,

Gomez

et al. 2023

The Journal of Haemophilia Practice

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The necessity of a multidisciplinary team (MDT) approach in haemophilia care is well recognised globally, with international guidelines advocating this. Prior to the coronavirus disease 2019 pandemic, virtual MDT haemophilia care was gaining support worldwide. However, the pandemic necessitated the rapid implementation of innovative virtual solutions to ensure continued access to multidisciplinary care. A multidisciplinary panel of healthcare professionals who specialise in haemophilia care in the United Kingdom gathered to discuss the following: the current landscape of haemophilia MDT care and best practices, the benefits, challenges, and opportunities for virtual MDT care, managing bleeds remotely, virtual paediatric care, and the future of virtual MDT care. The consensus was that virtual MDT care is widely used, however formats vary depending on the healthcare setting, available resources, MDT preferences, and local policy. Advisors agreed that virtual MDT care has several benefits, such as improved convenience/choice for their patients and wider patient reach. However, many patient-specific and logistical challenges exist. Hybrid care models may provide an opportunity to overcome these challenges. The decision on how bleeds are managed (virtually versus face-to-face) depends on provider preference, the patient-provider relationship, and the patient’s disease severity, history, and ability to self-manage. As such, this should be assessed on a case-by-case basis. Virtual tracking tools cannot be solely relied upon for MDT decisionmaking as patient accuracy cannot be ascertained. The MDT composition for paediatric care should be tailored to the patients’ and their parents’/caregivers’ needs. Lastly, hybridised care will likely be adopted for future haemophilia management and will facilitate the advancement of MDT care.

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Care for children with haemophilia during COVID‐19: Data of the PedNet study group

Cited by 2 publications

References 9 publications

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

Outcomes of COVID-19 in Adult Males With Hemophilia A: A Propensity Score-Matched Analysis

A multidisciplinary approach to optimising the virtual management of haemophilia: a roundtable meeting of UK experts

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