Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV–HCV International Panel

Soriano, Vincent; Sulkowski, Mark S.; Bergin, Colm; Hatzakis, Angelos; Cacoub, Patrice; Katlama, Christine; Cargnel, Antonietta; Mauss, Stefan; Dieterich, Douglas T.; Moreno, Santiago; Ferrari, Carlo; Poynard, Thierry; Rockstroh, Jürgen K.

doi:10.1097/00002030-200204120-00001

Cited by 309 publications

(219 citation statements)

References 93 publications

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“…The natural history of liver fibrosis progression in patients with HCV/HIV co-infection has been studied during the last decade. The high prevalence of HCV/HIV coinfection is ascribed to the shared transmission route, the most important being the use of intravenous drugs, which continues to be the greatest risk for acute HCV infection (12)(13)(14). In the United States and Europe, the prevalence of HCV/HIV co-infection is approximately 30% (12).…”

Section: Introductionmentioning

confidence: 99%

“…The high prevalence of HCV/HIV coinfection is ascribed to the shared transmission route, the most important being the use of intravenous drugs, which continues to be the greatest risk for acute HCV infection (12)(13)(14). In the United States and Europe, the prevalence of HCV/HIV co-infection is approximately 30% (12). In Brazil, the prevalence depends on the geographic area, with values ranging from 8.9 to 54% (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies conducted before the introduction of highly active antiretroviral therapy (HAART) have suggested that HIV infection changes the natural history of HCV infection, leading to more rapid progression of liver fibrosis (9,(23)(24)(25)(26)(27)(28). The progression, which typically takes 30 years or more in patients infected with HCV, could take less than half this time in co-infected patients (12).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV

Souza

Tovo

Mattos

et al. 2007

Braz J Med Biol Res

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV

Souza

Tovo

Mattos

et al. 2007

Braz J Med Biol Res

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“…Some studies have associated HCV coinfection with a faster HIV progression, although this conection is controversial 5,18,[21][22][23]30 . HCV infection also increases the toxicity to antiretroviral medications 9,18,26,27,32 .…”

Section: Introductionmentioning

confidence: 99%

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Hoyos-Orrego

Massaro-Ceballos

Ospina-Ospina

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYBoth hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological study for HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count ≤ 150 per mm 3 . Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.

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“…ESLD, hepatocellular carcinoma) [17]. Based on studies demonstrating an increased risk of cirrhosis and ESLD among HIV/HCV-coinfected patients compared to monoinfected patients, current HCV treatment guidelines recommend the use of peginterferon/ribavirin therapy in all eligible coinfected patients, even those with minimal liver disease [18]. However, these aggressive HCV treatment recommendations are based on assumption that the rate of HCV disease progression will be undeterred by the effective use of HAART.…”

mentioning

confidence: 99%

HAART and the HCV-infected liver: friend or foe?

Sulkowski

2004

Journal of Hepatology

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Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV–HCV International Panel

Cited by 309 publications

References 93 publications

There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV

There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus and those co-infected with HIV

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

HAART and the HCV-infected liver: friend or foe?

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