Caregiver Preferences for Emerging Duchenne Muscular Dystrophy Treatments: A Comparison of Best-Worst Scaling and Conjoint Analysis

Abstract

The observed concordance between approaches demonstrates the reliability of the stated-preference methods. Given the simplicity of combining BWS and conjoint analysis on single profiles, a combination approach is easily adopted. Minor irregularities for the conjoint-analysis results could not be explained by additional analyses and needs to be the focus of future research.

The Ball is in Your Court: Agenda for Research to Advance the Science of Patient Preferences in the Regulatory Review of Medical Devices in the United States

“…This is especially the case when comparing methods that come from different research disciplines, such as economics, decision science, psychology, market research, and health services research. We are aware of some recent and ongoing work in this area [26][27][28]; however, further research and potentially a theoretical approach are necessary.…”

The Imperative for Patient-Centred Research to Develop Better Quality Services in Rare Diseases

“…In response to the Food and Drug Administration's initiative to support patient-focused drug development, Parent Project Muscular Dystrophy collaborated with Hollin and colleagues to understand the treatment preferences of patients with Duchenne Muscular Dystrophy [8]. They tested the use of best-worse scaling vs conjoint analysis for 18 potential treatments with six attributes and three levels.…”

A Latent Class Analysis to Identify Variation in Caregivers’ Preferences for their Child’s Attention-Deficit/Hyperactivity Disorder Treatment: Do Stated Preferences Match Current Treatment?

“…Compared with standard Likert-type items, BWS techniques improve discriminatory power, while compared with other choice-based approaches such as discrete choice experiments, BWS techniques reduce cognitive demand [30–32]. Further, the BWS technique places greater emphasis on the relative importance of individual items, while discrete choice experiments emphasizes tradeoffs among different items [31]. As the purpose of this study is to examine how caregivers value the different components of their child’s ADHD treatment (as opposed to looking at the trade-offs between medication side effects and treatment efficacy), we felt that BWS was the most appropriate method.…”