The actual clinical use of smart wireless, software-based, mobile medical devices does not meet the recently raised expectations. First, current low level of interoperability calls for setting and enforcing open standards from the device level to the national/global collaboration structure. Second, heterogeneous and frequently changing devices, operating in various natural, technical and human environments, do not match the classical approval model. In addition to a time-limited set of clinical trials, they need a system of continuous quality monitoring. Third, ad-hoc deployment, without dedicated staff with well defined, novel skill sets is not scalable. A proper organizational structure is necessary. In this paper we present a modular software structure and a framework of a system supporting both the direct health care and the continuous quality evaluation. We expose the location of interfaces crucial for assuring multivendor interoperability. We then define a roadmap giving structure to the necessary development effort. The structure we propose should permit to coordinate the actions of independent teams tackling the immense number of multifaceted and interrelated tasks.