2009
DOI: 10.1091/mbc.e08-08-0892
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Cargo-Mediated Regulation of a Rapid Rab4-Dependent Recycling Pathway

Abstract: Membrane trafficking is well known to regulate receptor-mediated signaling processes, but less is known about whether signaling receptors conversely regulate the membrane trafficking machinery. We investigated this question by focusing on the beta-2 adrenergic receptor (B2AR), a G protein-coupled receptor whose cellular signaling activity is controlled by ligand-induced endocytosis followed by recycling. We used total internal reflection fluorescence microscopy (TIR-FM) and tagging with a pH-sensitive GFP vari… Show more

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Cited by 94 publications
(129 citation statements)
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“…SpH-B2AR clustered and internalized rapidly in response to agonist (Fig. 3A), as described previously (20,29). After 5 min, serial acquisition of images at 10-30 frames per second (fps) revealed transient bursts of SpH-B2AR fluorescence in the plasma membrane (Fig.…”
Section: Significancesupporting
confidence: 78%
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“…SpH-B2AR clustered and internalized rapidly in response to agonist (Fig. 3A), as described previously (20,29). After 5 min, serial acquisition of images at 10-30 frames per second (fps) revealed transient bursts of SpH-B2AR fluorescence in the plasma membrane (Fig.…”
Section: Significancesupporting
confidence: 78%
“…Downstream activation of PKA has a homeostatic effect on B2AR delivery to the surface, making it a good candidate (20). We first optimized a live-cell imaging assay to directly visualize and resolve B2AR endosomal sorting at the level of discrete events mediating B2AR recycling.…”
Section: Resultsmentioning
confidence: 99%
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