Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial

Abdellatif, Hoda; Ali, Amel M.; Baghdady, Sarah Ibrahim; Elkateb, Mona Abdallah

doi:10.1007/s40368-020-00592-0

Cited by 28 publications

(47 citation statements)

References 43 publications

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“…In this trial, a restoration failure to the point that the lesion is available for assessment of activity (texture, roughness) would be considered a minor failure. Similar to this trial, Abdellatif et al (2021) found that SDF was faster (3.3 min) than ART (14.4 min). ART is a less invasive approach and would require less chair time than the RT techniques that were ultimately chosen by dentists in this trial.…”

Section: Discussionsupporting

confidence: 78%

A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment

Cleary¹,

Al-Hadidi

Scully

et al. 2022

JDR Clinical & Translational Research

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Purpose: The aim of this 2-arm, parallel-group, 12-mo randomized clinical trial was to compare the effectiveness of semiannual application of 38% silver diamine fluoride (SDF) versus restorative treatment (RT) to manage cavitated caries lesions in primary teeth in a diverse population of children in Michigan. Methods: Children aged 2 to 10 y with at least 1 soft cavitated lesion (International Caries Detection and Assessment System 5 or 6) with no pain or signs/symptoms of irreversible pulpitis were recruited and randomly assigned to 2 intervention groups. One random lesion per child received 38% SDF (twice, at a 6-mo interval) or RT. All interventions and assessments were done by calibrated dentists. Primary outcome measures were clinical failure rates: minor (e.g., reversible pulpitis, active/soft lesion or progression, restoration loss or need for replacement/repair, secondary caries) and major (e.g., irreversible pulpitis, abscess, extraction). Parent, child, and provider acceptability was also assessed. Results: Ninety-eight children were enrolled and randomized, with a mean (SD) age of 4.8 y (1.8); 46% were female and their mean dmft + DMFT was 6.3 (3.9). Sixty-nine children were assessed at 12 mo (sample was within the planned 30% attrition rate). There were significantly more teeth with minor failures (SDF = 65%, RT = 23%, P ≤ 0.001) and major failures (SDF = 13%, RT = 3%, P ≤ 0.001) in the SDF group than the RT group; 74% of SDF-treated lesions were hard at 12 mo vs. 57% at 6 mo. Providers stated that SDF was easier, faster, and more preferable than RT ( P ≤ 0.001). No significant differences were found in parental satisfaction and acceptability. At 12 mo, children in the RT arm felt significantly ( P < 0.05) happier with their tooth appearance and stated that their visit to the dentist hurt less. Conclusion: At 12 mo, SDF-treated lesions had significantly more minor and major failures than RT, suggesting that SDF-treated teeth need to be closely monitored in a population at high caries risk (ClinicalTrials.gov NCT02601833). Knowledge of Transfer Statement: The results of this study can be used by clinicians when deciding whether to restore or apply silver diamine fluoride to cavitated lesions in primary teeth. Information on treatment outcomes and parent, child, and provider acceptability can help guide appropriate treatment decisions and need for monitoring.

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Section: Discussionsupporting

confidence: 78%

A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment

Cleary¹,

Al-Hadidi

Scully

et al. 2022

JDR Clinical & Translational Research

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“…These findings are like the studies present in the literature. 6 10 20 The practice of SDF was related to the workplace, experience, and specialty among dentists who agreed to participate in our study. This study supported the fact that dentists working at universities as consultants or on academic appointments had more educational knowledge of the use of SDF, compared with those who are self-employed; and the principal barrier to SDF use was a lack of knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…9 Twice a year, the application of 38% SDF solution can result in 84.8% arrest of carious lesions according to literature reports. 3,10 SDF is suggested as a minimally invasive treatment option for biomodification of repairable inner carious dentine a recent study by Firouzmandi et al shows that SDF increases microhardness and elastic modulus of caries affected dentine. 11 There is a scarcity of data in clinical research in the Asia Pacific region regarding how well dental schools educate their students about clinical techniques and indications of SDF.…”

Section: Introductionmentioning

confidence: 99%

“…9 Twice a year, the application of 38% SDF solution can result in 84.8% arrest of carious lesions according to literature reports. 3 10 SDF is suggested as a minimally invasive treatment option for biomodification of repairable inner carious dentine a recent study by Firouzmandi et al shows that SDF increases microhardness and elastic modulus of caries affected dentine. 11…”

Section: Introductionmentioning

confidence: 99%

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Perception, Knowledge, and Professional Behavior of Dentists about Silver Diamine Flouride: A Nationwide Survey

Abbas

Aamer

Anwar³

et al. 2021

European Journal of General Dentistry

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Objectives The aim of this study was to survey the educational experiences, knowledge, and attitude of dentists in Pakistan about the professional use of silver diamine fluoride (SDF). This study also aimed to determine if SDF educational experience at the undergraduate level can result in a more positive attitude and increased clinical usage of SDF. Materials and Methods This was a cross-sectional survey, conducted at multiple dental institutes across Pakistan using a pre-validated questionnaire to assess the knowledge, experience, and professional expertise of dentists regarding the use of SDF. The data were entered and analyzed using the SPSS (version 23.0) data management software by IBM. Results The results of this study were deemed significant in terms of achievement of the study aims. The majority of the responders, 178 (79.8%), reported online resources to be the main source of information about SDF treatment, whereas 103 (46.1%) responders gained information from a dental journal. A higher number of consultants were reported to be well educated regarding SDF treatment during their residency training as compared with demonstrators, house officers, and postgraduate trainees (p < 0.001). About 64 (28.7%) responders agreed that SDF is a better alternative treatment for children with behavioral issues, 74 (33.2%) agreed that it is a better treatment option for medically fragile patients, and 79 (35.4%) agreed that it can be used as an alternative for patients with dental anxiety. It was agreed by 82 (36.8%) responders that SDF is a good treatment option for patients who recently have received chemotherapy radiation therapy. Conclusion It is the need of time to put all educational efforts together to enhance knowledge regarding the use, advantages, and potential problems of SDF.

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“…In addition, the procedure is suitable for patients with special needs; for children whose age, dental anxiety, or behavioral or medical conditions do not allow a conventional treatment; in cases when parents are uncomfortable accepting general anesthesia or sedation for their children; and for children who have several cavities and cannot be treated in one session [ 8 , 9 , 10 , 11 ]. The application of SDF is painless and quick [ 9 , 12 ]. It is a minimally-invasive procedure for arresting untreated dental caries [ 12 ] and can help keep the tooth in position to maintain the mesio-distal space, since the tooth is the best space maintainer in primary or mixed dentition, avoiding extraction of the tooth [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Cytocompatibility of Silver Diamine Fluoride on Mesenchymal Stromal Cells from Human Exfoliated Deciduous Teeth: An In Vitro Study

2022

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Silver diamine fluoride (SDF) has been used for many years for the treatment of caries, and minimally invasive dentistry concepts have made it popular again. The fact that its application does not require the administration of anesthesia makes its use in children more desirable. The aim of this study was to determine the cytotoxicity of two new commercial SDF products: Riva Star (SDI Dental Limited) and e-SDF (Kids-e-Dental) on mesenchymal stromal cells from human exfoliated deciduous teeth (SHEDs). SHEDs were exposed to SDF products at different concentrations (0.1%, 0.01% and 0.005%). Then different assays were performed to evaluate their cytocompatibility on SHEDs: IC50, MTT, cell migration (wound healing), cell cytoskeleton staining, cell apoptosis, generation of intracellular reactive oxygen species (ROS), and ion chromatography. Statistical analyses were performed using one-way ANOVA and Tukey’s post hoc test (p < 0.05). Riva Star Step 2 showed the same cell metabolic activity when compared to the control condition at any time and concentration. Meanwhile, e-SDF displayed high cytotoxicity at any time and any concentration (*** p < 0.001), whereas Riva Star Step 1 displayed high cytotoxicity at any time at 0.1% and 0.01% (*** p < 0.001). Only e-SDF showed a statistically significant decreased cell migration rate (*** p < 0.001) at all times and in all concentrations. At 0.1%, e-SDF and Riva Star Step 1 only showed 4.37% and 4.47% of viable cells, respectively. These results suggest that Riva Star has better in vitro cytocompatibility on SHEDs than does e-SDF. Riva Star Step 1 was found to be as cytotoxic as e-SDF, but it had better biological properties when mixed with Riva Star Step 2. Our findings suggest that Riva Star is more suitable when used in deciduous teeth due to its lower cytotoxicity compared to e-SDF.

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Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial

Cited by 28 publications

References 43 publications

A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment

A 12-Month Randomized Clinical Trial of 38% SDF vs. Restorative Treatment

Perception, Knowledge, and Professional Behavior of Dentists about Silver Diamine Flouride: A Nationwide Survey

The Cytocompatibility of Silver Diamine Fluoride on Mesenchymal Stromal Cells from Human Exfoliated Deciduous Teeth: An In Vitro Study

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