Caries preventive effects of toothpastes containing monofluorophosphate and trimetaphosphate: a 3‐year clinical trial

Andlaw, R J; Palmer, John D.; King, J. Darwin; Kneebone, Steven B.

doi:10.1111/j.1600-0528.1983.tb01375.x

Cited by 17 publications

(6 citation statements)

References 11 publications

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“…Overall, a re duction in caries increments of 8% relative to a placebo was found for subjects completing the study and a difference of 11% for those subjects who regularly brushed twice daily. This result is in broad agreement with earlier clinical trials with TMP [Andlaw et al, 1983;Kinkel et al, 1985] which also indicated some anticaries benefit for this agent.…”

Section: Discussionsupporting

confidence: 82%

“…One such compound, sodium trimetaphosphate (TMP), a cyclic phosphate, had shown anticaries potential when test ed in animals [Henry and Navia, 1969;Shaw, 1980], It was subsequently investigated in several clinical trials involving toothpaste [Kinkel et al, 1974;Andlaw et al, 1983;Kinkel etal., 1985] and chewing gum [Finnetal., 1978], The results showed that TMP was a potential anticaries agent for use in toothpaste, either when used on its own [Andlaw et al, 1983] or in combination with fluoride [Kinkel et al, 1985], Based on these findings, further research using in vitro and in situ enamel models was carried out to optimise the potential efficacy o f TMP in toothpaste. This work resulted in a new toothpaste formulation which was found to be fully compatible with cyclic TMP, thus ensuring that the bio availability of the agent was maintained.…”

Section: Karg Ermentioning

confidence: 99%

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The Effect of Sodium Trimetaphosphate on Caries: A 3-year Clinical Toothpaste Trial

Städtler¹,

Müller-Bruckschwaiger²,

Schäfer

et al. 1996

Caries Res

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The objective of this study was to assess the anticaries efficacy of a toothpaste containing 3% sodium trimetaphosphate (TMP; test) relative to a toothpaste containing no caries-preventive agent (control). The study was designed as a 3-year double-blind caries incidence study involving about 2,500 subjects aged 11 years at baseline. After a clinical examination, subjects were stratified by sex, presence of supragingival calculus and caries status and randomly assigned to either the control or the test group. Clinical examinations then took place at annual intervals. At baseline and at the final examination bite-wing radiographs were taken of subjects not radiographed within the previous 6 months. The change in caries between baseline and the 3-year examination was calculated as DMFS increments. The result showed a statistically significant difference of 8% between the test and control groups (p < 0.05). In subjects brushing twice daily the difference between the test and control group was 11% (p < 0.01). It is concluded that, when used regularly, a toothpaste containing 3% TMP will be effective against caries.

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Section: Discussionsupporting

confidence: 82%

Section: Karg Ermentioning

confidence: 99%

The Effect of Sodium Trimetaphosphate on Caries: A 3-year Clinical Toothpaste Trial

Städtler¹,

Müller-Bruckschwaiger²,

Schäfer

et al. 1996

Caries Res

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“…Mean baseline caries and calculus prevalence data from six trials are listed in table 2, whilst corresponding 3-year caries increment data and calculus prevalence at the end of each trial are listed in table 3. [8] and Somerset [9] 1 ϭ calculus on anteriors only 2 ϭ calculus on molars II 1 ϭ no calculus Bristol [10], Berkshire [11], Munster [12], 2 ϭ sub-gingival calculus Villefranche [13] and Isle of Lewis [14] 3 ϭ supra-gingival calculus 4 ϭ sub-and supra-gingival calculus For the current data analysis, the presence of calculus was denoted by scores of 1 or 2 for the type I index and 3 or 4 for the type II index. The exception is the Villefranche trial where no 4s and very few 3s were recorded, so that 2 or 3 have been used.…”

Section: Unilever-sponsored Studiesmentioning

confidence: 99%

On the Relationship between Calculus and Caries

Duckworth

Huntington²

2005

Monographs in Oral Science

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From a mechanistic viewpoint it is reasonable to anticipate an inverse clinical relationship between calculus and caries. Calculus formation is essentially a mineralisation process. The development of a caries lesion is the result of the net demineralisation of tooth enamel by plaque acid. These processes both involve crystalline calcium phosphate phases in contact with liquid, saliva and/or plaque fluid, containing their constituent ions. The oral environment also contains other salivary constituents and bacteria, which either inhibit or promote crystal growth or dissolution.An inverse relationship would mean that the absence of calculus could be a useful predictor of caries. Historically, however, any calculus-caries relationship has often been obscured by other factors. Firstly, the prevalence of both calculus and caries increases with increasing age [1, 2] and, second, both conditions are expected to correlate positively with poor oral hygiene [3][4][5]. These trends could be the reason why Schroeder [1] found no consistent relationship between clinical observations of calculus and caries experience in the first major review of the topic.The main purpose of this chapter is to review data from several clinical trials sponsored by Unilever, in which both caries and supra-gingival calculus were assessed concomitantly, in order to assess the strength of any empirical relationship between the two conditions. These data are presented in the following section 1.2, together with the results of other relevant published studies. To provide background information against which to judge the findings derived from the clinical data, calculus formation and caries are then briefly described Chapter 1

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“…[ 7 ] and Andlaw et al . [ 14 ] Leo Hanachowicz[ 15 ] reported a reduction of 26% in DMFT and 27% in DMFS values, on using 1.2% sodium monofluorophosphate dentifrice for a duration of 3 years. Studies carried out in naturally fluoridated areas by Lind et al .…”

Section: Discussionmentioning

confidence: 99%

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

Damle¹,

Deoyani²,

Bhattal³

et al. 2012

Dent Res J

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Background:The efficacy of fluoridated dentifrices in caries prevention has been well documented and research into various formulations continues for a more effective dentifrice. This study evaluated the anti-caries and anti-plaque efficacy of a dentifrice containing sodium monofluorophosphate (1000 ppm) and calcium glycerophosphate, and compared it with a non-fluoridated dentifrice.Materials and Methods:A total of 595 school children (12–15 years) were divided into test (302 children) and control (293 children) groups. The test group used the dentifrice containing sodium monofluorophosphate (1000 ppm) and calcium glycerophosphate, whereas the control group was given a placebo dentifrice. Oral examination for dental caries and plaque assessment was carried out at the start of the study and the children were followed up semiannually up to 18 months. Data were analyzed using repeated-measure analysis of variance (ANOVA) followed by one-way ANOVA.Results:The values for decayed missing filled teeth (DMFT) increased from baseline to 18 month examination from 4.43±2.03 and 4.67±2.25 (P=0.175) to 5.84±2.29 and 5.13±2.30 (P=0.001) for control and test groups, respectively. Similarly, the increase in decayed missing filled surface (DMFS) values were from 6.42±4.10 and 7.06±4.77 (P=0.082) to 8.64±4.51 and 7.92±5.07 (P=0.095) for test and control groups, respectively. The mean DMFT and DMFS values increased for both the groups; however, the increase was less in test group as compared to control group. The baseline plaque score reduced from 2.94±0.72 and 2.91±0.72 (P=0.679), respectively, for control and test groups to 1.33±0.46 and 0.91±0.38 (P<0.001), respectively, at 18 month examination.Conclusion:Results revealed that the test dentifrice was effective in inhibiting the progression of plaque and control of dental caries as compared to the placebo dentifrice.

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Caries preventive effects of toothpastes containing monofluorophosphate and trimetaphosphate: a 3‐year clinical trial

Cited by 17 publications

References 11 publications

The Effect of Sodium Trimetaphosphate on Caries: A 3-year Clinical Toothpaste Trial

The Effect of Sodium Trimetaphosphate on Caries: A 3-year Clinical Toothpaste Trial

On the Relationship between Calculus and Caries

Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study

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