Caries preventive effects of xylitol-based candies and lozenges: a systematic review

Antônio, Andréa Gonçalves; Pierro, Viviane Santos da Silva; Maia, Lucianne Cople

doi:10.1111/j.1752-7325.2010.00208.x

Cited by 39 publications

(25 citation statements)

References 30 publications

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“…suggests that xylitol could have tooth-surface-specific cariespreventive effects (Antonio et al, 2011) but did not examine coronal vs. root surfaces. Furthermore, most evidence of xylitol for caries prevention is derived from studies on children and adolescents with no root surfaces at risk.…”

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confidence: 99%

Tooth-surface-specific Effects of Xylitol

et al. 2013

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The Xylitol for Adult Caries Trial was a three-year, double-blind, multi-center, randomized clinical trial that evaluated the effectiveness of xylitol vs. placebo lozenges in the prevention of dental caries in caries-active adults. The purpose of this secondary analysis was to investigate whether xylitol lozenges had a differential effect on cumulative caries increments on different tooth surfaces. Participants (ages 21-80 yrs) with at least one follow-up visit (n = 620) were examined at baseline, 12, 24, and 33 months. Negative binomial and zero-inflated negative binomial regression models were used to estimate incidence rate ratios (IRR) for xylitol's differential effect on cumulative caries increments on root and coronal surfaces and, among coronal surfaces, on smooth (buccal and lingual), occlusal, and proximal surfaces. Participants in the xylitol arm developed 40% fewer root caries lesions (0.23 D 2 FS/year) than those in the placebo arm (0.38 D 2 FS/year; IRR = 0.60; 95% CI [0.44, 0.81]; p < .001). There was no statistically significant difference between xylitol and control participants in the incidence of smoothsurface caries (p = .100), occlusal-surface caries (p = .408), or proximal-surface caries (p = .159). Among these caries-active adults, xylitol appears to have a caries-preventive effect on root surfaces (ClinicalTrials.gov NCT00393055).

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confidence: 99%

Tooth-surface-specific Effects of Xylitol

et al. 2013

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“…A study by Ly et al [12] has proved that ingesting 10.32 g of xylitol in chewing gum daily results in a significant reduction of the SM count in resting saliva and dental plaque and that there is an inverse proportion between the frequency of using xylitol chewing gum and the bacteria count. Antonio et al [17], in their literature review regarding candies and lozenges, have noted that such means of applying xylitol may decrease the increment of caries, however they do not appear effective toward the interproximal surfaces of teeth. Shortterm application of chewing gum reduces the SM count in saliva but does not affect the composition of oral microbiota [32].…”

Section: Discussionmentioning

confidence: 99%

“…Also, the sort of xylitol-containing product and the manner of its consumption (chewing gum, lozenges, syrup, etc.) was significant [17]. The impact of additives to products containing xylitol on the development of oral microbiota is also worth noting.…”

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Xylitol Content in Dental Care and Food Products Available on the Polish Market and Their Significance in Caries Prevention

Turska‐Szybka¹,

Pasternok²,

Olczak‐Kowalczyk³

2016

Dent. Med. Probl.

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Sugar alcohols (or polyols), natural organic compounds, may be used in order to replace sucrose. There are many sugar alcohols administered in dental care and food products, such as maltitol, lactitol, sorbitol, mannitol, erythritol and xylitol.Xylitol (E 967) is a five-carbon sugar alcohol of crystalline structure and sweetness similar to sucrose and has the same relative sweetness, which is 1, and provides less energy compared to sucrose (2.4 kcal vs 4 kcal). It occurs naturally in certain fruits, such as plums, raspberries and strawberries, and in birch trees; it is also developed in the digestive reactions of the human body in the amount of 15 g/day. It can be industrially produced using products rich in xylans, such as corncobs and birch wood. Xylitol obtained in the reduction reaction of xylose in the presence of catalytic converters is used in the food and cosmetic industry as an ingredient of chewing gum, lozenges, sprays, mouth rinses, gels, toothpastes, wipes, candies and AbstractCaries pertains to most of the Polish community and is associated with a high intake of sucrose and monosaccharides. Their non-cariogenic analogue is xylitol -equally sweet as sucrose, but not metabolized by the majority of bacteria existing in the oral cavity. The aim of this paper is to evaluate the content of xylitol in dental care and food products available on the Polish market and their significance in caries prevention. The products were selected based on the literature, informational leaflets and information from manufacturers. The toothpastes and gels taken into consideration contain up to 25% xylitol, mouth rinses -25%, dental care sprays -35%, chewing gum -66-67% and candies -96%. A large number of dental care and food products recommended in caries prevention contain xylitol in diverse concentrations. If caries-producing sugars are replaced with non-cariogenic sugar alcohols, the frequency of caries may be diminished. On one hand, xylitol, as an acknowledged anti-carious agent, is included in many caries-prevention programs, in precise concentrations and regularly used, on the other hand -there is a lack of EBM (Evidence-Based Medicine) data indicating the effectiveness of xylitol, apart from those pertaining to fluoride toothpastes with the addition of xylitol. It is emphasized that more detailed trials are necessary to answer the question whether it is xylitol that is relevant in caries prevention or the alteration of habits -lessened sucrose intake or its complete substitution with a sweetener and the act of chewing, which stimulates salivation (Dent. Med. Probl. 2016, 53, 4, 542-550).

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“…After excluding studies that did not allow an adequate interpretation, only 3 studies were included in the meta-analysis, and the results indicated a caries-preventive effect of evaluated products. 43 According to Huebner et al, 44 literature reviews on the use of xylitol are important because the dissemination of research-based information on xylitol to dentists in clinical practice is quite limited. As a result, published evidence on mother-to-child transmission of S. mutans or xylitol efficacy is practically unknown, which limits the interest on the action of this polyol as well as the emergence of new research.…”

Section: Discussionmentioning

confidence: 99%

Propriedades antibacterianas e anticariogênicas do xilitol: uma revisão da literatura

Cabral-Oliveira

Freires

Oliveira

et al. 2018

Rev. Bras. Odontol.

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Objective: the purpose of this study was to review some properties of xylitol as an antimicrobial agent and the role of this sugar alcohol in the prevention and control of dental caries activity. Material and Methods: the study was based on PubMed scientific papers, in addition of evaluating older researches, to obtain a more complete view of this polyol, encompassing its biochemical, antibacterial, antibiofilm and toxic properties, as well as its different forms of use. Results: the study carried out highlighted the positive characteristics of xylitol in relation to its use in humans and its possible therapeutic use as a substance for the prevention and control of caries disease. Conclusion: It was concluded that, though the scientific documentation that reinforce its efficiency in caries prevention, some authors still do not consider the clinical evidence as satisfactory about the effects of xylitol, and recommend better controlled clinical investigations, especially in relation to the prolonged use of this polyol, in order to provide more conclusive data.

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Caries preventive effects of xylitol-based candies and lozenges: a systematic review

Abstract: This research demonstrates the need for well-designed randomized clinical studies with adequate control groups and high compliance by the subjects.

Cited by 39 publications

References 30 publications

Tooth-surface-specific Effects of Xylitol

Tooth-surface-specific Effects of Xylitol

Xylitol Content in Dental Care and Food Products Available on the Polish Market and Their Significance in Caries Prevention

Propriedades antibacterianas e anticariogênicas do xilitol: uma revisão da literatura

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