Caring experiences of family caregivers of patients with pancreatic cancer: an integrative literature review

Kim, Yoonjoo; Baek, Wonhee

doi:10.1007/s00520-021-06793-7

Cited by 15 publications

(16 citation statements)

References 41 publications

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“…Caregiving affects family caregiver lifestyle in many ways, including changes in employment, changes in parent–child and spousal roles in relationships, and disruptions in schedules (eg, frequent hospital visits) 3 7. Family caregivers have experienced difficulties in balancing the new and existing roles focused on patients with cancer, and some caregivers were caring for patients as a priority 2 7. Caregivers in this study may have to change their lifestyle given their time contribution for caregiving, averaging 13.2 hours per day, 5.7 days per week.…”

Section: Discussionmentioning

confidence: 98%

“…In this study, the higher the perceived psychological or physical stress, the lower QoL due to lifestyle disruption, which resulted in decreased IL-6 levels. Caregiving affects family caregiver lifestyle in many ways, including changes in employment, changes in parent–child and spousal roles in relationships, and disruptions in schedules (eg, frequent hospital visits) 3 7. Family caregivers have experienced difficulties in balancing the new and existing roles focused on patients with cancer, and some caregivers were caring for patients as a priority 2 7.…”

Section: Discussionmentioning

confidence: 99%

“…Efforts to improve QoL life related to lifestyle disruption in caregivers may reduce the impact on immune function that has been associated with poor outcomes from stress. For example, it suggests that opportunity caregivers to recognise and express their situation, opportunities for respite from caring and available support such as home care may help improve their QoL along with stress management 7…”

Section: Discussionmentioning

confidence: 99%

“…Thus, family caregivers provide complex care for patients with cancer, including monitoring and managing pain and symptoms, administering drug support, helping in daily living activities and offering emotional and financial support 2 6. Although some caregivers reported positive changes due to caregiving experiences (eg, new appreciation of the value of life or better health habits),2 7 they also experienced a high level of stress 2. When family caregivers perceived caregiving responsibilities or tasks as stressful, their quality of life (QoL) was poor 8…”

Section: Introductionmentioning

confidence: 99%

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Caregivers of patients with cancer: perceived stress, quality of life and immune function

Kim

Chung

Lee

2022

BMJ Support Palliat Care

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ObjectivesTo examine the mediating effect of quality of life (QoL) on the relationship between perceived stress and immune function in Korean family caregivers of patients with cancer.MethodsIn this cross-sectional study, 89 family caregivers of patients with cancer completed perceived stress and QoL questionnaires. Immune function was assessed using two proinflammatory biomarkers, IL-6 and tumour necrosis factor-alpha (TNF-α). Multiple parallel mediator regression was conducted using four mediators (burden, lifestyle disruption, positive adaptation and financial concern) representing the subscales of QoL related to caregiving.ResultsPsychological (indirect effect (ab)=−0.52, 95% CI −1.25 to −0.01) and physical (ab=−0.44, 95% CI −1.07 to −0.05) stress had a significant indirect effect on IL-6 levels attributed to lifestyle disruption associated with caregiving. Psychological (ab=−0.97, 95% CI −2.37 to −0.11) and physical (ab=−1.10, 95% CI −2.87 to −0.08) stress also had a significant indirect effect on TNF-α as a result of financial concerns owing to caregiving. Other indirect effects of psychological/physical stress on inflammation were not significant.ConclusionThis study demonstrated that the effects of perceived psychological and physical stress on IL-6 and TNF-α levels were mediated by the caregiver’s QoL, especially lifestyle disruption and financial concerns. Stress management and improvement of caregivers’ QoL related to lifestyle disruption and financial issues should be considered to reduce the negative effects of caregiving on immune function.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Caregivers of patients with cancer: perceived stress, quality of life and immune function

Kim

Chung

Lee

2022

BMJ Support Palliat Care

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“…Family caregivers are primarily responsible for caring for cancer patients and providing physical, mental, social, and economic support, as well as performing therapeutic roles, such as symptom management and monitoring, without any remuneration [ 5 ]. Although family support contributes to improving outcomes in cancer patients, family caregivers encounter multifaceted burdens in their role and lifestyle including employment changes, disrupted schedules, and challenges to their emotional well-being [ 6 ]. Owing to increased responsibilities, they cannot afford to take care of themselves and tend to hide and suppress negative emotions [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Depression on Quality of Life in Caregivers of Cancer Patients: A Moderated Mediation Model of Spousal Relationship and Caring Burden

Kim

2022

Current Oncology

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Family caregivers play an important role in managing and supporting cancer patients. Although depression in family caregivers is known to negatively affect caregiver health, the mechanism by which it affects caregivers is not clear. The purpose of this study was to explore the influence of depression on quality of life (QoL) in family caregivers of patients with cancer. Specifically, this study examined (1) whether caring burden mediates the relationship between depression and QoL, and (2) how this mediating effect varies depending on the caregiver’s relationship with the patient. This study performed a secondary analysis on cross-sectional survey data. Ninety-three family caregivers of cancer patients were included in the study. Moderated mediation analyses were conducted using PROCESS macro with the regression bootstrapping method. The moderated mediation models and the indirect effect of caregiver depression on QoL through caring burden were significantly different depending on caregivers’ relationships with patients (i.e., spousal or non-spousal). Specifically, the indirect effect of caregiver depression on QoL was greater for the patient’s spouse than for other family caregivers. Healthcare providers should focus on identifying caregivers’ depression and relationship with the patient and offer tailored support and intervention to mitigate the caring burden and improve the caregivers’ QoL.

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Machine learning to predict completion of treatment for pancreatic cancer

Pasha,

Khalid,

Levy

et al. 2024

Journal of Surgical Oncology

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BackgroundChemotherapy enhances survival rates for pancreatic cancer (PC) patients postsurgery, yet less than 60% complete adjuvant therapy, with a smaller fraction undergoing neoadjuvant treatment. Our study aimed to predict which patients would complete pre‐ or postoperative chemotherapy through machine learning (ML).MethodsPatients with resectable PC identified in our institutional pancreas database were grouped into two categories: those who completed all intended treatments (i.e., surgery plus either neoadjuvant or adjuvant chemotherapy), and those who did not. We applied logistic regression with lasso penalization and an extreme gradient boosting model for prediction, and further examined it through bootstrapping for sensitivity.ResultsAmong 208 patients, the median age was 69, with 49.5% female and 62% white participants. Most had an Eastern Cooperative Oncology Group (ECOG) performance status of ≤2. The PC predominantly affected the pancreatic head. Neoadjuvant and adjuvant chemotherapies were received by 26% and 47.1%, respectively, but only 49% completed all treatments. Incomplete therapy was correlated with older age and lower ECOG status. Negative prognostic factors included worsening diabetes, age, congestive heart failure, high body mass index, family history of PC, initial bilirubin levels, and tumor location in the pancreatic head. The models also flagged other factors, such as jaundice and specific cancer markers, impacting treatment completion. The predictive accuracy (area under the receiver operating characteristic curve) was 0.67 for both models, with performance expected to improve with larger datasets.ConclusionsOur findings underscore the potential of ML to forecast PC treatment completion, highlighting the importance of specific preoperative factors. Increasing data volumes may enhance predictive accuracy, offering valuable insights for personalized patient strategies.

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Caring experiences of family caregivers of patients with pancreatic cancer: an integrative literature review

Cited by 15 publications

References 41 publications

Caregivers of patients with cancer: perceived stress, quality of life and immune function

Caregivers of patients with cancer: perceived stress, quality of life and immune function

The Impact of Depression on Quality of Life in Caregivers of Cancer Patients: A Moderated Mediation Model of Spousal Relationship and Caring Burden

Machine learning to predict completion of treatment for pancreatic cancer

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