Background: Mental disorders, particularly schizophrenia, present significant challenges in modern medical and psychological sciences. Addressing these disorders effectively requires not only technical expertise but also continuous, strong family support. Despite the crucial role of familial support in maintaining treatment continuity for individuals with schizophrenia, this area faces numerous challenges that demand in-depth examination and strategic intervention. Objectives: This study explores the challenges involved in sustaining familial support for individuals with schizophrenia. Methods: This qualitative study employed content analysis and gathered data through semi-structured interviews with 20 families of individuals diagnosed with schizophrenia and healthcare professionals at Roozbeh Psychiatric Hospital in Tehran, Iran. Participants were selected through purposive sampling, and data analysis followed the conventional content analysis principles of Lundman and Graneheim. Results: The analysis identified four main categories: (1) the nature of the disease; (2) care burden; (3) cultural barriers; and (4) challenges within the healthcare system. Conclusions: Providing effective family support requires technical expertise in schizophrenia care, alongside ongoing policy measures aimed at addressing obstacles and enhancing familial involvement. These findings offer valuable insights for improving family support programs and mental health policies to better serve individuals with schizophrenia, thus contributing to overall community mental health.