Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel

Giacaman, Rodrigo A.; Campos, Pía; Muñoz‐Sandoval, Cecilia; Castro, Ricardo I.

doi:10.1016/j.archoralbio.2013.03.005

Cited by 68 publications

(59 citation statements)

References 33 publications

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“…A previous in vitro study has also shown that a commercial stevioside sweetener containing lactose promoted significantly less biofilm acidogenicity and fewer viable cells than a 10% sucrose solution. 9 However, the present in vivo study found that the commercial stevioside sweetener containing lactose promoted dental biofilm acidogenicity (AUC 6.5 ) similar to that of the 18% sucrose solution, despite differences in the minimum pH values. …”

Section: Discussioncontrasting

confidence: 46%

“…In vitro studies have shown reduced numbers of biofilm-viable cells and polysaccharide formation. 7,8,9,10 However, commercial products contain several components and formulations that might influence their cariogenicity. These sugars and their derivatives have been added to sweeteners as excipient agents.…”

Section: Introductionmentioning

confidence: 99%

“…13 A recent in vitro study also showed that a commercial aspartame sweetener containing lactose promotes significantly higher biofilm acidogenicity and higher counts of viable S. mutans cells than a commercial stevioside sweetener containing lactose. 9 The antimicrobial effect of stevioside could influence the cariogenic properties of commercial sweetening products. There is no in vivo study analyzing the cariogenic potential of commercial stevioside products containing lactose.…”

Section: Introductionmentioning

confidence: 99%

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Effects of lactose-containing stevioside sweeteners on dental biofilm acidogenicity

et al. 2014

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The aim of this study was to evaluate the effect of a commercial lactose-containing stevioside sweetener on biofilm acidogenicity in vivo. Nine volunteers refrained from brushing their teeth for 3 days in five phases. On the 4th day of each phase, the pH of the biofilm was measured by the "Strip method". Interproximal plaque pH was measured before and up to 60 minutes after a 10 mL mouthrinse for 1 minute with the test solutions: I -sweetener with 93% lactose and 7% stevioside; II -sweetener with 6.8% saccharin, 13.6% cyclamate, and 0.82% stevioside; III -18% sucrose solution (positive control); IV -mineral water (negative control); and V-93% lactose solution. The results revealed that the most pronounced pH fall was found with sucrose (positive control), followed by the 93% lactose solution, the sweetener with lactose + stevioside, the sweetener with saccharin + cyclamate + stevioside, and finally water (negative control). According to the area under the curve, the two sweeteners containing stevioside were significantly different, and the sweetener with lactose + stevioside was significantly different from water but not from sucrose. The critical pH for dentin demineralization (pH ≤ 6.5) was reached by all volunteers after rinsing with sucrose solution, lactose solution, and the stevioside + lactose sweetener. Analysis of the data suggests that lactose-containing stevioside sweeteners may be cariogenic, especially to dentin.

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Section: Discussioncontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of lactose-containing stevioside sweeteners on dental biofilm acidogenicity

et al. 2014

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“…However, researches about the effect on teeth of the commercial sweeteners currently available, is rather insufficient 62 . It is important to highlight that, most of the available research of an anti-caries effect or not presumptive cariogenic of the sweetener comes from the pure chemical compound.…”

Section: Propertiesmentioning

confidence: 99%

“…It is important to highlight that, most of the available research of an anti-caries effect or not presumptive cariogenic of the sweetener comes from the pure chemical compound. Information about the cariogenicity of sweeteners when they are combined with filling carbohydrates is more limited and may be important in enamel and dentin caries 62 .…”

Section: Propertiesmentioning

confidence: 99%

Anticariogenic properties and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review.

Contreras¹

2013

J Oral Res

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Resin‐modified glass ionomer enriched with BIOGLASS: Ion‐release, bioactivity and antibacterial effect

et al. 2022

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Developing dental materials for the prevention of remineralization or demineralization is important for high‐risk caries patients. This study aimed to evaluate the physicochemical and microbiological effects of adding 45S5 bioglass to resin‐modified glass ionomer cement (RMGIC). Samples belonged to the following groups: GIC: conventional glass ionomer cement (Vitro Fil), RMGIC: resin‐modified GIC (Vitro Fil LC), and RMGIC/45S5: RMGIC with 10% (wt %) of 45S5. Changes in pH and release of fluoride, calcium, and phosphorus ions under acidic (pH 4) and neutral (pH 7) pH conditions were evaluated. Antibacterial activity was verified based on colony‐forming units. Material sorption and solubility were analyzed after bacterial exposure. After 28 days, the bioactivity of the materials was evaluated using scanning electron microscopy/energy dispersive X‐ray spectroscopy (SEM/EDS). Analysis of variance, post hoc Scheffe, and Tukey (α = 0.05) tests were employed for statistical analysis. RMGIC/45S5 showed higher alkalization activity, calcium release at pH 4 and 7, and sorption than GIC and RMGIC (p < .05). Release of phosphorus and fluoride at pH 4 and 7 was higher for GIC than that for RMGIC and RMGIC/45S5 (p < .05). RMGIC/45S5 showed higher values than RMGIC (p < .05). However, antibacterial activity did not differ among the groups. Precipitates of calcium and phosphorus were visualized in RMGIC/45S5 samples via SEM/EDS. These results indicate that the RMGIC/45S5 promotes alkalization and increases the release of calcium, phosphorus, and fluoride ions, resulting in precipitate deposition rich in calcium and phosphorus, thereby being a promising option to improve the bioactivity of RMGIC.

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Cariogenic potential of commercial sweeteners in an experimental biofilm caries model on enamel

Cited by 68 publications

References 33 publications

Effects of lactose-containing stevioside sweeteners on dental biofilm acidogenicity

Effects of lactose-containing stevioside sweeteners on dental biofilm acidogenicity

Anticariogenic properties and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review.

Resin‐modified glass ionomer enriched with BIOGLASS: Ion‐release, bioactivity and antibacterial effect

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