Cariogenicity in hamsters of Streptococcus mutans AHT mutants with varying in vitro adherence abilities

Kishimoto, Etsuo; Kinoshita, Toshihiko; Inoue, Masakazu

doi:10.2330/joralbiosci1965.20.292

Cited by 1 publication

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“…Therefore, these results indicate that cell-associated glucan synthesis by S. sanguis from sucrose does not necessarily result in significant cellular adherence to smooth surfaces. Related to this, certain noncariogenic mutants of serotype g S. mutans strains have been reported to possess properties similar to those of S. sanguis in terms of glucan synthesis and cell adherence to glass surfaces (7,14,16,28). The chemical structure of glucans produced by S. sanguis should differ from that of S. mutans glucans in spite of the water insolubility of both glucans.…”

Section: Discussionmentioning

confidence: 96%

Adherence of Streptococcus sanguis clinical isolates to smooth surfaces and interactions of the isolates with Streptococcus mutans glucosyltransferase

Hamada¹,

Torii²,

Kotani³

et al. 1981

Infect Immun

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Streptococcus sanguis isolated from human dental plaque were grown in Todd-Hewitt broth. Cells were collected by centrifugation and lyophilized after extensive washing with water. The cell-associated glucosyltransferase (GTase) activities of S. sanguis strains were assayed with ['4C]sucrose. Strain differences in GTase activity were significant within the same serotype or biotype or both. The ability of S. sanguis cells to adhere to smooth glass surfaces was generally weak, irrespective of significant cell-associated GTase activity synthesizing water-insoluble, gel-like glucans. Resting cells of most S. sanguis strains bound extracellular GTase from Streptococcus mutans strain B13 (serotype d), resulting in the strong adherence of the S. sanguis cells to smooth glass surfaces in the presence of sucrose. Conversely, S. mutans B13 cells also could bind extracellular GTase from some strains of S. sanguis examined. The sucrose-dependent adherence of S. mutans cells was not altered, although S. sanguis strains from which the extracellular GTases were obtained did not produce significant adherence in the presence of sucrose. In view of these findings, it was suggested that S. mutans GTase could affect the adherence of S. sanguis to smooth tooth surfaces in the oral cavity.

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Section: Discussionmentioning

confidence: 96%