Carissa carandas Linn. fruit extract ameliorates gentamicin–induced nephrotoxicity in rats via attenuation of oxidative stress

Dhodi, Jayesh B.; Thanekar, Deepavali R; Mestry, Snehal N.; Juvekar, Archana R.

doi:10.1016/s2221-6189(15)30023-8

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…The BUN level was significantly lower in group fed with 30% FKWB (G 4 ), while creatinine levels were at par each other in groups fed with FKWB (G 2 , G 3 and G 4 ). The similar result was reported in nephrotoxicity induced rats fed on methanolic extract of Carissa carandas fruit extract (Dhodi et al, 2015). The results even corroborated with finding reported by Ranganathanet al (2005) and Ranganathan et al (2009) when rats and patients suffering from chronic kidney disease were fed on probiotic formulation, respectively.…”

Section: Biochemical Parameters Blood Urea Nitrogen (Bun) and Creatinsupporting

confidence: 90%

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Sawant

Chandra

Yadav

2017

IJAR

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The present study was conducted to evaluate the impact of feeding fermented karonda whey beverage(FKWB) on biochemical parameters of albino rats. A total of 24 albino rats (male) of age 28±3 days and weighing 80 to 95 gm were randomly divided into four groups (n=6) and assigned to experimental dietary treatment. Experimental groups consisted of control group fed with basal ration only and groups fed with basal ration containing 10%, 20% and 30% FKWB. Results showed that levels of BUN, creatinine, SGOT, SGPT were significantly (p>0.05) lower in FKWB fed groups, signifying positive impact of FKWB on functioning of kidney and liver. FKWB consumption had no significant (p>0.05) effect on cholesterol and protein levels, while its consumption reduced triglyceride level.

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Section: Biochemical Parameters Blood Urea Nitrogen (Bun) and Creatinsupporting

confidence: 90%

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Sawant

Chandra

Yadav

2017

IJAR

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“…In this study, the histological analyses of kidney sections from gentamicin-treated animals (negative control) showed inflammations, fibrosis, tubular clarifications, glomerular hypertrophy, and degeneration with a reduced urinary space. Previous studies described this renal tissue damage induced by gentamicin as well [36,47]. e histological analysis of kidney sections from animals treated with AECZ or silymarin presented an aspect that is similar to that of normal animals.…”

Section: Discussionmentioning

confidence: 69%

“…Any toxic substance that triggers good functioning of the kidney provokes an inflammatory response in the kidney tissue, as well as its hypertrophy [46,47]; the increase of the kidney's relative weight observed in animal group that received gentamicin could have probably resulted from the edema that was caused by drug-induced acute tubular necrosis. e plant extract as well as silymarin significantly mitigated the kidney hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract from Cinnamomum zeylanicum (Lauraceae) Stem Bark Ameliorates Gentamicin-Induced Nephrotoxicity in Rats by Modulating Oxidative Stress and Inflammatory Markers

Atsamo

Songmene

Donfack

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Nephropathies and especially nephrotoxicity have become one of the serious causes of life-threatening conditions because of intensive exposure to xenobiotic whether by environmental pollution or by drug abuse. The present study was undertaken to assess the protective effects of Cinnamomum zeylanicum stem bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ was prepared by maceration in water and tested orally at the doses of 200 and 400 mg/kg/day to prevent gentamicin-induced nephropathies in male Wistar rats. Gentamicin (100 mg/kg/day) was administered for 14 consecutive days by intraperitoneal route, concomitantly with AECZ or silymarin (50 mg/kg/day) used as reference drug. Animal body weight was monitored during the treatment. After the last treatment on the 14th day, animals were sacrificed. Blood was collected for the evaluation of hematological and renal function biomarkers. The homogenate of one kidney was used to assess oxidative stress markers and proinflammatory cytokines, while the other one was fixed in formaldehyde for histopathological studies. Gentamicin decreased body weight, serum total proteins, and calcium level but increased kidneys’ relative weight, serum creatinine, urea, and uric acid. Moreover, the levels of reduced glutathione, catalase, and superoxide dismutase activities were decreased, while an increase in malondialdehyde, proinflammatory cytokines (TNF-α, IL-1β, and IL-6), and nitrites was observed in the negative control group as compared to normal control. Histological analysis of the kidney revealed the presence of tubular necrosis, glomerular degeneration, and macrophage infiltration in the gentamicin-treated group. All these impairment parameters were prevented by AECZ and silymarin treatments. AECZ has a protective effect against gentamicin-induced nephrotoxicity. The antioxidant and anti-inflammatory potentials of this extract may highly contribute to its nephroprotective activity.

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“…The histological analyses of kidney sections from gentamicin-treated animals (negative control) showed in ammations, brosis, tubular clari cations, glomerular hypertrophy and degeneration with a reduced urinary space. Previous studies described as well these renal tissue damages induced by gentamicin (Dhodi et al 2015;Randjelović et al 2017). The histological analysis of kidney sections from animals treated with AECZ (200 mg/kg and 400 mg/kg) as well as Silymarin presented an aspect similar to that of normal animals.…”

Section: )mentioning

confidence: 89%

“…The proteolysis and reduced proteins synthesis was con rmed in this study through the decrease of the level of total proteins in the serum and kidneys of gentamicin-treated animal. Any toxic substance that triggers a good functioning of the kidney provokes an in ammatory response in the kidney tissue, as well as it hypertrophies (Witthawaskul et al 2003;Dhodi et al 2015); this may justify the increase of relative kidney weight observed in animal group that received gentamicin. The aqueous extract as well as Silymarin signi cantly improved body weight gain, prevented the decrease of the total serum proteins and the increase of kidney relative weight.…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract from Cinnamomum zeylanicum (Lauraceae) stem-bark ameliorates gentamicin-induced nephrotoxicity in rats by modulating oxidative stress and inflammatory markers

Atsamo

SONGMENE

Donfack

et al. 2021

Preprint

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Nephropathies and especially nephrotoxicity has become one of serious cause of life threatening condition, because of intensive exposure to xenobiotic either by environmental pollution or drug abuse. The present study was undertaken to assess the protective effects of Cinnamomum zeylanicum stem-bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ was prepared by maceration in water and tested orally at the doses of 200 and 400 mg/kg/day to prevent gentamicin induced nephropathies in male Wistar rats. Gentamicin (100 mg/kg/day) was administered for 14 consecutive days by intraperitoneal route, concomitantly with AECZ or silymarin (50 mg/kg/day) used as reference drug. Animal body weight was monitored during the treatment. After the last treatment of the 14 th day, a 24h urine was collected and animals were sacrificed. Blood was collected for the evaluation of hematological and renal function biomarkers. The homogenate of one kidney was used to assess oxidative stress markers and pro-inflammatory cytokine, while the other one was fixed in formaldehyde for histopathological studies. Gentamicin decreased body weight, serum total proteins and calcemia, but increased kidneys relative weight, serum creatinine, urea and uric acid. Moreover, the levels of reduced glutathione, catalase and superoxide dismutase activities were decreased, while an increase in malondialdehyde, proinflammatory cytokines (TNFα, IL-1β, IL-6) and nitrites were observed in negative control group as compared to normal control. Histological analysis of the kidney revealed the presence of tubular necrosis, glomerular degeneration and macrophage infiltration in gentamicin treated group. All these impairment parameters were prevented by AECZ and silymarin treatments.AECZ has a protective effect against gentamicin-induced nephrotoxicity. The antioxidant and anti-inflammatory potentials of this extract may highly contribute to its nephroprotective activity.

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Carissa carandas Linn. fruit extract ameliorates gentamicin–induced nephrotoxicity in rats via attenuation of oxidative stress

Cited by 12 publications

References 16 publications

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Assessment of impact of feeding fermented karonda (Carissa carandas) whey beverage on biochemical parameters of albino rats

Aqueous Extract from Cinnamomum zeylanicum (Lauraceae) Stem Bark Ameliorates Gentamicin-Induced Nephrotoxicity in Rats by Modulating Oxidative Stress and Inflammatory Markers

Aqueous extract from Cinnamomum zeylanicum (Lauraceae) stem-bark ameliorates gentamicin-induced nephrotoxicity in rats by modulating oxidative stress and inflammatory markers

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