Carney Complex: case report and review

Abstract

Carney complex is a very rare multiple neoplasia syndrome with cardiac, cutaneous, and neural tumours with a variety of pigmented lesion of skin. We are reporting a rare case of carney complex in which left atrial myxoma with superficial angiomyxoma, giant cell tumour of bone and lentigines showed a unique association. This patient underwent successful surgical excision of left atrial myxoma under cardiopulmonary bypass.

Osteochondromyxoma: Review of a rare carney complex criterion

“…chondroblastoma, chondromyxoid fibroma, rhabdomyosarcoma, mxyoid chondrosarcoma, and neurofibroma) [26], [27]. OMX can occur in any bone but most frequently presents on the diaphysis of long bones (especially the tibia and radius) as well as the sinus and nasal bones [2], [5], [16], [21], [27], [28], [29]. Two cases have reported occlusion of the nasal sinus due to an OMX tumor [5], [18].…”

“…Osteochondromyxoma is characterized as a painless mass with additional symptoms due to edema and mass effect [5], [7], [27], [29]. One case, for example, involved an infant with a tumor blocking the nasal turbinate, which led to difficulties with breastfeeding [5].…”

“…One case, for example, involved an infant with a tumor blocking the nasal turbinate, which led to difficulties with breastfeeding [5]. Since OMX is associated with 1% of patients with Carney complex, other symptoms pertaining to CNC may present, namely cardiovascular and endocrine abnormalities along with spotty skin pigmentation [28], [29], [33]. While OMX in young patients is associated with Carney complex, OMX in adults can occur as an isolated entity [5].…”

“…About 1% of Carney complex patients exhibit osteochondromyxoma [1], [29]. It is believed to arise from distorted mesenchymal stem cells designated to become osteoblasts [4], [25].…”

Purpuric Eruption on the Feet of a Healthy Young Woman—Diagnosis

“…5 Local recurrence following excision of superficial angiomyxomas occurs in 30% to 40% of patients. 8 Mutations in PRKAR1A, a tumor suppressor gene, have been identified in approximately 60% of cases of Carney complex. The lesions are poorly circumscribed myxoid tumors centered in the dermis with frequent extension into the subcutaneous fat and sometimes skeletal muscle.…”